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Pradc1 protease-associated domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 73327, updated on 28-Apr-2024

Summary

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Official Symbol
Pradc1provided by MGI
Official Full Name
protease-associated domain containing 1provided by MGI
Primary source
MGI:MGI:1920577
See related
Ensembl:ENSMUSG00000030008 AllianceGenome:MGI:1920577
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pap21; 1700040I03Rik
Summary
Predicted to be located in extracellular region. Is expressed in submandibular gland primordium and thymus primordium. Orthologous to human PRADC1 (protease associated domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 8.3), thymus adult (RPKM 7.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 C3; 6 37.46 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (85423767..85428969, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (85446785..85451987, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene notochord homeobox Neighboring gene SET and MYND domain containing 5 Neighboring gene chaperonin containing TCP1 subunit 7 Neighboring gene F-box protein 41 Neighboring gene early growth response 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PRADC1: a novel metabolic-responsive secretory protein that modulates physical activity and adiposity. Rodriguez S, et al. FASEB J, 2019 Dec. PMID 31689374, Free PMC Article
  2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PRADC1-deficient mice have reduced adiposity and enhanced locomotor activity uncoupled from metabolic health.
    Title: PRADC1: a novel metabolic-responsive secretory protein that modulates physical activity and adiposity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protease-associated domain-containing protein 1
Names
protease-associated domain-containing protein of 21 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163427.1 → NP_001156899.1  protease-associated domain-containing protein 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001156899.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a longer protein (isoform b) compared to isoform a.
    Source sequence(s)
    AC155728, AK006658, CJ208123
    Consensus CDS
    CCDS51828.1
    UniProtKB/Swiss-Prot
    Q9D9N8
    Related
    ENSMUSP00000032080.3, ENSMUST00000032080.9
    Conserved Domains (1) summary
    cd02127
    Location:51 → 168
    PA_hPAP21_like; Protease-associated domain containing proteins like the human secreted glycoprotein hPAP21 (human protease-associated domain-containing protein, 21kDa). This group contains various PA domain-containing proteins similar to hPAP21. Complex N-glycosylation ...

  2. NM_028505.2 → NP_082781.1  protease-associated domain-containing protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_082781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a).
    Source sequence(s)
    AC155728, AK006658, CJ208123
    Consensus CDS
    CCDS39538.1
    UniProtKB/TrEMBL
    Q14C45
    Related
    ENSMUSP00000109400.2, ENSMUST00000113770.2
    Conserved Domains (1) summary
    cl28883
    Location:51 → 112
    PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...

RNA

  1. NR_028081.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains two alternate exons compared to variant 1. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because there is uncertainty about the protein-coding capacity of the transcript.
    Source sequence(s)
    AC155728, AK006658, BG088874, CJ075544, CJ208123
    Related
    ENSMUST00000126805.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    85423767..85428969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241486.2 → XP_011239788.1  protease-associated domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011239788.1

    UniProtKB/Swiss-Prot
    Q9D9N8
    Conserved Domains (1) summary
    cd02127
    Location:51 → 168
    PA_hPAP21_like; Protease-associated domain containing proteins like the human secreted glycoprotein hPAP21 (human protease-associated domain-containing protein, 21kDa). This group contains various PA domain-containing proteins similar to hPAP21. Complex N-glycosylation ...

RNA

  1. XR_003956256.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D9N8.1 GenPept UniProtKB/Swiss-Prot:Q9D9N8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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