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Ube2d2b ubiquitin-conjugating enzyme E2D 2B [ Mus musculus (house mouse) ]

Gene ID: 73318, updated on 11-Apr-2024

Summary

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Official Symbol
Ube2d2bprovided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2D 2Bprovided by MGI
Primary source
MGI:MGI:1920568
See related
Ensembl:ENSMUSG00000063447 AllianceGenome:MGI:1920568
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700013N18Rik
Summary
Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase activity. Predicted to be involved in protein K11-linked ubiquitination and protein K48-linked ubiquitination. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human UBE2D2 (ubiquitin conjugating enzyme E2 D2) and UBE2D3 (ubiquitin conjugating enzyme E2 D3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Ube2d2b in Genome Data Viewer
Location:
5 F; 5 52.23 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (107978028..107979643)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (107830162..107831777)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Gfi1 +5.8 kb enhancer Neighboring gene Gfi1 promoter regions Neighboring gene -8.7 kb enhancer upstream of Gfi1 Neighboring gene growth factor independent 1 transcription repressor Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:108168116-108168348 Neighboring gene predicted gene, 42147 Neighboring gene Gfi1 -35 kb enhancer Neighboring gene ecotropic viral integration site 5 Neighboring gene STARR-seq mESC enhancer starr_13892 Neighboring gene STARR-seq mESC enhancer starr_13893 Neighboring gene predicted gene, 42149 Neighboring gene STARR-positive B cell enhancer ABC_E9017 Neighboring gene small nucleolar RNA, C/D box 21 Neighboring gene ribosomal protein L5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†. Lu Y, et al. Biol Reprod, 2019 Aug 1. PMID 31201419, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Clone Names

  • 1700013N18Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K27-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K29-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K6-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 D2B
Names
E2 ubiquitin-conjugating enzyme D2B
ubiquitin carrier protein D2B
ubiquitin-protein ligase D2B
NP_001263326.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276397.1 → NP_001263326.1  ubiquitin-conjugating enzyme E2 D2B

    See identical proteins and their annotated locations for NP_001263326.1

    Status: VALIDATED

    Source sequence(s)
    AC138666
    Consensus CDS
    CCDS71632.1
    UniProtKB/Swiss-Prot
    Q6ZWY6
    UniProtKB/TrEMBL
    Q3U5V6, Q9D1S1
    Related
    ENSMUSP00000072387.7, ENSMUST00000072578.8
    Conserved Domains (1) summary
    cl00154
    Location:1 → 146
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    107978028..107979643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_028502.2: Suppressed sequence

    Description
    NM_028502.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.

  2. NR_003639.1: Suppressed sequence

    Description
    NR_003639.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZWY6.1 GenPept UniProtKB/Swiss-Prot:Q6ZWY6

Gene LinkOut

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