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Ttc29 tetratricopeptide repeat domain 29 [ Mus musculus (house mouse) ]

Gene ID: 73301, updated on 5-Mar-2024

Summary

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Official Symbol
Ttc29provided by MGI
Official Full Name
tetratricopeptide repeat domain 29provided by MGI
Primary source
MGI:MGI:1920551
See related
Ensembl:ENSMUSG00000037101 AllianceGenome:MGI:1920551
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700031F13Rik
Summary
Involved in cilium movement. Located in sperm flagellum. Is expressed in 4th ventricle lateral recess and lateral ventricle choroid plexus. Human ortholog(s) of this gene implicated in spermatogenic failure 42. Orthologous to human TTC29 (tetratricopeptide repeat domain 29). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 31.7) See more
Orthologs
human all
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Genomic context

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Location:
8 C1; 8 36.86 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (78939911..79120955)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (78213282..78394326)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21968 Neighboring gene STARR-seq mESC enhancer starr_21971 Neighboring gene predicted gene 6360 Neighboring gene STARR-seq mESC enhancer starr_21973 Neighboring gene STARR-seq mESC enhancer starr_21976 Neighboring gene predicted gene 45574 Neighboring gene predicted gene, 39202 Neighboring gene STARR-seq mESC enhancer starr_21980 Neighboring gene STARR-seq mESC enhancer starr_21981 Neighboring gene STARR-seq mESC enhancer starr_21983 Neighboring gene STARR-seq mESC enhancer starr_21984 Neighboring gene POU domain, class 4, transcription factor 2 Neighboring gene predicted gene 2225

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Bi-allelic Mutations in TTC29 Cause Male Subfertility with Asthenoteratospermia in Humans and Mice. Liu C, et al. Am J Hum Genet, 2019 Dec 5. PMID 31735294, Free PMC Article
  2. Mutations in TTC29, Encoding an Evolutionarily Conserved Axonemal Protein, Result in Asthenozoospermia and Male Infertility. Lorès P, et al. Am J Hum Genet, 2019 Dec 5. PMID 31735292, Free PMC Article
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium movement IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium movement ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat protein 29
Names
TPR repeat protein 29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183096.3 → NP_898919.3  tetratricopeptide repeat protein 29

    See identical proteins and their annotated locations for NP_898919.3

    Status: VALIDATED

    Source sequence(s)
    AC117544, AC133181, AC140845
    Consensus CDS
    CCDS22428.1
    UniProtKB/Swiss-Prot
    Q80VM3, Q8CF30
    UniProtKB/TrEMBL
    E9QLU4
    Related
    ENSMUSP00000041919.9, ENSMUST00000049395.15
    Conserved Domains (2) summary
    TIGR02917
    Location:245 → 380
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:275 → 308
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    78939911..79120955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248517.3 → XP_011246819.1  tetratricopeptide repeat protein 29 isoform X1

    See identical proteins and their annotated locations for XP_011246819.1

    UniProtKB/Swiss-Prot
    Q80VM3, Q8CF30
    UniProtKB/TrEMBL
    E9QLU4
    Conserved Domains (2) summary
    TIGR02917
    Location:245 → 380
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:275 → 308
    TPR; TPR repeat [structural motif]

  2. XM_011248518.3 → XP_011246820.1  tetratricopeptide repeat protein 29 isoform X1

    See identical proteins and their annotated locations for XP_011246820.1

    UniProtKB/Swiss-Prot
    Q80VM3, Q8CF30
    UniProtKB/TrEMBL
    E9QLU4
    Conserved Domains (2) summary
    TIGR02917
    Location:245 → 380
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:275 → 308
    TPR; TPR repeat [structural motif]

  3. XM_011248516.3 → XP_011246818.1  tetratricopeptide repeat protein 29 isoform X1

    See identical proteins and their annotated locations for XP_011246818.1

    UniProtKB/Swiss-Prot
    Q80VM3, Q8CF30
    UniProtKB/TrEMBL
    E9QLU4
    Conserved Domains (2) summary
    TIGR02917
    Location:245 → 380
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:275 → 308
    TPR; TPR repeat [structural motif]

  4. XM_006531400.2 → XP_006531463.1  tetratricopeptide repeat protein 29 isoform X1

    See identical proteins and their annotated locations for XP_006531463.1

    UniProtKB/Swiss-Prot
    Q80VM3, Q8CF30
    UniProtKB/TrEMBL
    E9QLU4
    Related
    ENSMUSP00000105528.3, ENSMUST00000109902.4
    Conserved Domains (2) summary
    TIGR02917
    Location:245 → 380
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:275 → 308
    TPR; TPR repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80VM3.1 GenPept UniProtKB/Swiss-Prot:Q80VM3

Gene LinkOut

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