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Rhobtb3 Rho-related BTB domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 73296, updated on 21-Apr-2024

Summary

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Official Symbol
Rhobtb3provided by MGI
Official Full Name
Rho-related BTB domain containing 3provided by MGI
Primary source
MGI:MGI:1920546
See related
Ensembl:ENSMUSG00000021589 AllianceGenome:MGI:1920546
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0878; 1700040C17Rik; 2610033K01Rik; 4930503C18Rik
Summary
Predicted to enable GTPase activity; enzyme binding activity; and purine ribonucleoside triphosphate binding activity. Acts upstream of or within male gonad development. Located in cytoplasm. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; respiratory system; and skeletal musculature. Orthologous to human RHOBTB3 (Rho related BTB domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 11.7), limb E14.5 (RPKM 9.8) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 C1; 13 40.95 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (76017656..76092054, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (75869537..75943824, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 2 pseudogene Neighboring gene predicted gene, 41005 Neighboring gene STARR-seq mESC enhancer starr_35051 Neighboring gene glutaredoxin Neighboring gene predicted gene, 24163 Neighboring gene WD repeat domain 77 pseudogene Neighboring gene ribosomal protein S2 pseudogene Neighboring gene spermatogenesis associated 9 Neighboring gene predicted gene, 23319

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Alterations in Platelet Alpha-Granule Secretion and Adhesion on Collagen under Flow in Mice Lacking the Atypical Rho GTPase RhoBTB3. Berger M, et al. Cells, 2019 Feb 11. PMID 30754723, Free PMC Article
  2. The complete sequence of perlecan, a basement membrane heparan sulfate proteoglycan, reveals extensive similarity with laminin A chain, low density lipoprotein-receptor, and the neural cell adhesion molecule. Noonan DM, et al. J Biol Chem, 1991 Dec 5. PMID 1744087
  3. Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. Ramos S, et al. Gene, 2002 Oct 2. PMID 12426103
  4. RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect. Zhang CS, et al. Cell Res, 2015 Sep. PMID 26215701, Free PMC Article
  5. Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain. Lutz J, et al. Histochem Cell Biol, 2014 Nov. PMID 24923387

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circular RNA circRHOBTB3 inhibits ovarian cancer progression through PI3K/AKT signaling pathway.
    Title: Circular RNA circRHOBTB3 inhibits ovarian cancer progression through PI3K/AKT signaling pathway.
  2. genetic deletion of Rhobtb3 leads to subtle alterations in alpha-granule secretion and adhesion to collagen without significant effects on hemostasis in vivo.
    Title: Alterations in Platelet Alpha-Granule Secretion and Adhesion on Collagen under Flow in Mice Lacking the Atypical Rho GTPase RhoBTB3.
  3. embryo and adult gene expression profiling
    Title: Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain.
  4. The authors identified MUF1 as the first substrate for RhoBTB-Cul3 ubiquitin ligase complexes.
    Title: MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
rho-related BTB domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418860.1 → NP_001405789.1  rho-related BTB domain-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122242, AC158356

  2. NM_028493.3 → NP_082769.1  rho-related BTB domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_082769.1

    Status: VALIDATED

    Source sequence(s)
    AC122242, AC158356
    Consensus CDS
    CCDS26652.1
    UniProtKB/Swiss-Prot
    Q05DP2, Q3UTS4, Q80X55, Q9CTN4, Q9CVT0
    Related
    ENSMUSP00000022078.6, ENSMUST00000022078.12
    Conserved Domains (3) summary
    smart00225
    Location:421 → 518
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:413 → 515
    BTB; BTB/POZ domain
    cl21455
    Location:34 → 174
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    76017656..76092054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517411.5 → XP_006517474.1  rho-related BTB domain-containing protein 3 isoform X2

    Conserved Domains (4) summary
    cd18357
    Location:236 → 393
    BTB1_POZ_RHOBTB3; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
    cd18532
    Location:471 → 553
    BACK_RHOBTB3; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
    cl38908
    Location:410 → 461
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    cl38936
    Location:34 → 174
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_036158195.1 → XP_036014088.1  rho-related BTB domain-containing protein 3 isoform X5

    Conserved Domains (3) summary
    cd18357
    Location:42 → 199
    BTB1_POZ_RHOBTB3; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
    cd18360
    Location:216 → 325
    BTB2_POZ_RHOBTB3; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
    cd18532
    Location:335 → 417
    BACK_RHOBTB3; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)

  3. XM_011244574.3 → XP_011242876.1  rho-related BTB domain-containing protein 3 isoform X4

    Conserved Domains (3) summary
    cd18357
    Location:102 → 259
    BTB1_POZ_RHOBTB3; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
    cd18360
    Location:276 → 385
    BTB2_POZ_RHOBTB3; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
    cd18532
    Location:395 → 477
    BACK_RHOBTB3; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)

  4. XM_011244573.3 → XP_011242875.1  rho-related BTB domain-containing protein 3 isoform X3

    Conserved Domains (3) summary
    cd18357
    Location:140 → 297
    BTB1_POZ_RHOBTB3; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
    cd18360
    Location:314 → 423
    BTB2_POZ_RHOBTB3; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
    cd18532
    Location:433 → 515
    BACK_RHOBTB3; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CTN4.3 GenPept UniProtKB/Swiss-Prot:Q9CTN4

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