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Gpbp1 GC-rich promoter binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 73274, updated on 5-Mar-2024

Summary

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Official Symbol
Gpbp1provided by MGI
Official Full Name
GC-rich promoter binding protein 1provided by MGI
Primary source
MGI:MGI:1920524
See related
Ensembl:ENSMUSG00000032745 AllianceGenome:MGI:1920524
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gpbp; mGPBP; 1700034P14Rik; D230035M11Rik
Summary
Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human GPBP1 (GC-rich promoter binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 28.7), CNS E11.5 (RPKM 24.3) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 D2.2; 13 63.23 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (111562214..111626658, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (111425680..111490128, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene actin, beta-like 2 Neighboring gene electron transfer flavoprotein subunit alpha, mitochondrial pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2421 Neighboring gene STARR-positive B cell enhancer ABC_E1468 Neighboring gene STARR-seq mESC enhancer starr_35655 Neighboring gene STARR-seq mESC enhancer starr_35658 Neighboring gene predicted gene 15290 Neighboring gene STARR-seq mESC enhancer starr_35661 Neighboring gene STARR-seq mESC enhancer starr_35662 Neighboring gene predicted gene 15286 Neighboring gene STARR-positive B cell enhancer ABC_E10815

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription. Hsu LC, et al. Mol Cell Biol, 2003 Dec. PMID 14612417, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. binds specifically to the adenosine deaminase gene promoter
    Title: The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
vasculin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122963.3 → NP_001116435.1  vasculin isoform 1

    See identical proteins and their annotated locations for NP_001116435.1

    Status: VALIDATED

    Source sequence(s)
    AC118475
    Consensus CDS
    CCDS49362.1
    UniProtKB/Swiss-Prot
    Q3TQR2, Q3TSN7, Q6NXH3, Q6TYE7, Q8C498, Q8R252
    Related
    ENSMUSP00000088777.5, ENSMUST00000091236.11
    Conserved Domains (1) summary
    pfam15337
    Location:377 → 457
    Vasculin; Vascular protein family Vasculin-like 1

  2. NM_001361923.2 → NP_001348852.1  vasculin isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC118475
    Conserved Domains (1) summary
    pfam15337
    Location:273 → 352
    Vasculin; Vascular protein family Vasculin-like 1

  3. NM_001361924.2 → NP_001348853.1  vasculin isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC118475
    Conserved Domains (1) summary
    pfam15337
    Location:252 → 331
    Vasculin; Vascular protein family Vasculin-like 1

  4. NM_001361925.2 → NP_001348854.1  vasculin isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC118475
    Conserved Domains (1) summary
    pfam15337
    Location:207 → 286
    Vasculin; Vascular protein family Vasculin-like 1

  5. NM_001361926.2 → NP_001348855.1  vasculin isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC118475
    Conserved Domains (1) summary
    pfam15337
    Location:207 → 286
    Vasculin; Vascular protein family Vasculin-like 1

  6. NM_028487.6 → NP_082763.3  vasculin isoform 2

    See identical proteins and their annotated locations for NP_082763.3

    Status: VALIDATED

    Source sequence(s)
    AC118475
    Consensus CDS
    CCDS26769.1
    UniProtKB/Swiss-Prot
    Q6NXH3
    Related
    ENSMUSP00000048240.8, ENSMUST00000047627.14
    Conserved Domains (1) summary
    pfam15337
    Location:397 → 477
    Vasculin; Vascular protein family Vasculin-like 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    111562214..111626658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247436.2 → XP_030103296.1  vasculin isoform X3

    Conserved Domains (1) summary
    pfam15337
    Location:273 → 352
    Vasculin; Vascular protein family Vasculin-like 1

  2. XM_030247435.2 → XP_030103295.1  vasculin isoform X2

    UniProtKB/Swiss-Prot
    Q3TQR2, Q3TSN7, Q6NXH3, Q6TYE7, Q8C498, Q8R252
    Conserved Domains (1) summary
    pfam15337
    Location:377 → 457
    Vasculin; Vascular protein family Vasculin-like 1

  3. XM_006517772.2 → XP_006517835.1  vasculin isoform X1

    See identical proteins and their annotated locations for XP_006517835.1

    UniProtKB/Swiss-Prot
    Q6NXH3
    Conserved Domains (1) summary
    pfam15337
    Location:397 → 477
    Vasculin; Vascular protein family Vasculin-like 1

  4. XM_036158193.1 → XP_036014086.1  vasculin isoform X3

    Conserved Domains (1) summary
    pfam15337
    Location:273 → 352
    Vasculin; Vascular protein family Vasculin-like 1

  5. XM_036158194.1 → XP_036014087.1  vasculin isoform X4

    Conserved Domains (1) summary
    pfam15337
    Location:207 → 286
    Vasculin; Vascular protein family Vasculin-like 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NXH3.1 GenPept UniProtKB/Swiss-Prot:Q6NXH3

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