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Rassf6 Ras association (RalGDS/AF-6) domain family member 6 [ Mus musculus (house mouse) ]

Gene ID: 73246, updated on 11-Apr-2024

Summary

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Official Symbol
Rassf6provided by MGI
Official Full Name
Ras association (RalGDS/AF-6) domain family member 6provided by MGI
Primary source
MGI:MGI:1920496
See related
Ensembl:ENSMUSG00000029370 AllianceGenome:MGI:1920496
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1600016B17Rik
Summary
Involved in regulation of apoptotic process. Acts upstream of or within positive regulation of apoptotic process. Is expressed in gut; liver lobe; urinary system; and vibrissa. Orthologous to human RASSF6 (Ras association domain family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 6.2), colon adult (RPKM 3.6) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 E1; 5 44.78 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (90750933..90788594, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (90603076..90640734, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zinc finger, BED domain containing 4 pseudogene Neighboring gene albumin superfamily member 1 Neighboring gene predicted gene, 42109 Neighboring gene STARR-positive B cell enhancer ABC_E4764 Neighboring gene STARR-seq mESC enhancer starr_13601 Neighboring gene STARR-seq mESC enhancer starr_13602 Neighboring gene STARR-seq mESC enhancer starr_13603 Neighboring gene predicted gene, 36084 Neighboring gene C-X-C motif chemokine ligand 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of mouse embryonic fibroblasts derived from Rassf6 knockout mice shows the implication of Rassf6 in the regulation of NF-κB signaling. Morishita M, et al. Genes Cells, 2021 Dec. PMID 34652874
  2. RASSF6 expression in adipocytes is down-regulated by interaction with macrophages. Sanada Y, et al. PLoS One, 2013. PMID 23626755, Free PMC Article
  3. RASSF6 is a novel member of the RASSF family of tumor suppressors. Allen NP, et al. Oncogene, 2007 Sep 13. PMID 17404571
  4. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  5. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterization of mouse embryonic fibroblasts derived from Rassf6 knockout mice shows the implication of Rassf6 in the regulation of NF-kappaB signaling.
    Title: Characterization of mouse embryonic fibroblasts derived from Rassf6 knockout mice shows the implication of Rassf6 in the regulation of NF-κB signaling.
  2. RASSF6 expression in adipocytes is down-regulated by interaction with macrophages.
    Title: RASSF6 expression in adipocytes is down-regulated by interaction with macrophages.
  3. Demonstrates properties of a Ras effector and tumor suppressor but exhibits biological properties that are unique and distinct from those of other family members.
    Title: RASSF6 is a novel member of the RASSF family of tumor suppressors.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
ras association domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310656.2 → NP_001297585.1  ras association domain-containing protein 6 isoform 2

    See identical proteins and their annotated locations for NP_001297585.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC135240
    Consensus CDS
    CCDS80327.1
    UniProtKB/Swiss-Prot
    Q80UQ2
    Related
    ENSMUSP00000144337.2, ENSMUST00000202784.4
    Conserved Domains (2) summary
    pfam16517
    Location:278 → 316
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl00155
    Location:178 → 264
    UBQ; Ubiquitin-like proteins

  2. NM_001407901.1 → NP_001394830.1  ras association domain-containing protein 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC135240
    UniProtKB/Swiss-Prot
    G3X8Z9, Q80UQ2, Q9DAW2

  3. NM_001407903.1 → NP_001394832.1  ras association domain-containing protein 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC135240
    UniProtKB/Swiss-Prot
    G3X8Z9, Q80UQ2, Q9DAW2
    Related
    ENSMUSP00000144532.2, ENSMUST00000202704.4

  4. NM_001407905.1 → NP_001394834.1  ras association domain-containing protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC135240

  5. NM_028478.4 → NP_082754.2  ras association domain-containing protein 6 isoform 1

    See identical proteins and their annotated locations for NP_082754.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC135240
    Consensus CDS
    CCDS39142.1
    UniProtKB/Swiss-Prot
    G3X8Z9, Q80UQ2, Q9DAW2
    Related
    ENSMUSP00000031317.7, ENSMUST00000031317.10
    Conserved Domains (2) summary
    pfam16517
    Location:291 → 329
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:191 → 277
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RNA

  1. NR_176431.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC135240

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    90750933..90788594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249579.4 → XP_011247881.1  ras association domain-containing protein 6 isoform X5

    See identical proteins and their annotated locations for XP_011247881.1

    Conserved Domains (1) summary
    cl28922
    Location:38 → 124
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. XM_006535245.4 → XP_006535308.1  ras association domain-containing protein 6 isoform X3

    See identical proteins and their annotated locations for XP_006535308.1

    UniProtKB/Swiss-Prot
    G3X8Z9, Q80UQ2, Q9DAW2
    Conserved Domains (2) summary
    pfam16517
    Location:291 → 329
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:191 → 277
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  3. XM_006535244.4 → XP_006535307.1  ras association domain-containing protein 6 isoform X2

    Conserved Domains (2) summary
    pfam16517
    Location:307 → 345
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:207 → 293
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  4. XM_006535241.3 → XP_006535304.1  ras association domain-containing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006535304.1

    Conserved Domains (2) summary
    pfam16517
    Location:320 → 358
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:220 → 306
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  5. XM_006535249.4 → XP_006535312.1  ras association domain-containing protein 6 isoform X4

    Conserved Domains (2) summary
    pfam16517
    Location:233 → 271
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:133 → 219
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  6. XM_006535243.5 → XP_006535306.1  ras association domain-containing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006535306.1

    Conserved Domains (2) summary
    pfam16517
    Location:320 → 358
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:220 → 306
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  7. XM_006535242.5 → XP_006535305.1  ras association domain-containing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006535305.1

    Conserved Domains (2) summary
    pfam16517
    Location:320 → 358
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:220 → 306
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RNA

  1. XR_001784751.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80UQ2.2 GenPept UniProtKB/Swiss-Prot:Q80UQ2

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