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Atat1 alpha tubulin acetyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 73242, updated on 21-Apr-2024

Summary

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Official Symbol
Atat1provided by MGI
Official Full Name
alpha tubulin acetyltransferase 1provided by MGI
Primary source
MGI:MGI:1913869
See related
Ensembl:ENSMUSG00000024426 AllianceGenome:MGI:1913869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TAT; Mec17; MEC-17; 0610011P08Rik; 2610008K08Rik; 2610110G12Rik; 3110080J08Rik
Summary
Enables tubulin N-acetyltransferase activity. Acts upstream of or within several processes, including alpha-tubulin acetylation; dentate gyrus development; and positive regulation of NLRP3 inflammasome complex assembly. Located in microtubule bundle. Is expressed in several structures, including adrenal gland; central nervous system; gut; male reproductive gland or organ; and neural retina. Orthologous to human ATAT1 (alpha tubulin acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 75.6), CNS E14 (RPKM 67.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 18.75 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36208487..36220971, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35897595..35910086, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:36016615-36016802 Neighboring gene DEAH-box helicase 16 Neighboring gene RIKEN cDNA 2310061I04 gene Neighboring gene STARR-positive B cell enhancer ABC_E10949 Neighboring gene predicted gene 16279 Neighboring gene mitochondrial ribosomal protein S18B Neighboring gene STARR-seq mESC enhancer starr_42481 Neighboring gene protein phosphatase 1, regulatory subunit 10 Neighboring gene microRNA 1894

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression and localization of alpha-tubulin N-acetyltransferase 1 in the reproductive system of male mice. Yanai R, et al. J Reprod Dev, 2021 Feb 15. PMID 33390366, Free PMC Article
  2. ATAT1 regulates forebrain development and stress-induced tubulin hyperacetylation. Li L, et al. Cell Mol Life Sci, 2019 Sep. PMID 30953095
  3. α-Tubulin Acetylation Restricts Axon Overbranching by Dampening Microtubule Plus-End Dynamics in Neurons. Dan Wei, et al. Cereb Cortex, 2018 Sep 1. PMID 28968698
  4. ATAT1 is essential for regulation of homeostasis-retaining cellular responses in corticotrophs along hypothalamic-pituitary-adrenal axis. Nakakura T, et al. Cell Tissue Res, 2017 Oct. PMID 28687926
  5. Α-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesion. Aguilar A, et al. Mol Biol Cell, 2014 Jun 15. PMID 24743598, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression and localization of alpha-tubulin N-acetyltransferase 1 in the reproductive system of male mice.
    Title: Expression and localization of alpha-tubulin N-acetyltransferase 1 in the reproductive system of male mice.
  2. PAK1 Regulates MEC-17 Acetyltransferase Activity and Microtubule Acetylation during Proplatelet Extension.
    Title: PAK1 Regulates MEC-17 Acetyltransferase Activity and Microtubule Acetylation during Proplatelet Extension.
  3. The Major Capsid Protein, VP1, of the Mouse Polyomavirus Stimulates the Activity of Tubulin Acetyltransferase 1 by Microtubule Stabilization.
    Title: The Major Capsid Protein, VP1, of the Mouse Polyomavirus Stimulates the Activity of Tubulin Acetyltransferase 1 by Microtubule Stabilization.
  4. p27(Kip1) stabilizes the alpha-tubulin acetyltransferase 1, thereby promoting the acetylation of microtubules, a post-translational modification required for proper axonal transport.
    Title: p27(Kip1) Modulates Axonal Transport by Regulating α-Tubulin Acetyltransferase 1 Stability.
  5. ATAT1 found in regulating mouse forebrain development and governing tubulin hyperacetylation during stress responses, but also suggests the existence of an additional alpha-tubulin acetyltransferase.
    Title: ATAT1 regulates forebrain development and stress-induced tubulin hyperacetylation.
  6. TAK1 directly interacts with and phosphorylates alphaTAT1 at Ser237 to critically enhance its catalytic activity.
    Title: TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth.
  7. Atat1 knockdown resulted in a significant increase in the expression of ACTH-producing genes and decreased the dexamethasone-induced nuclear translocation of glucocorticoid receptor accompanied with a reduction in alpha-tubulin acetylation.
    Title: ATAT1 is essential for regulation of homeostasis-retaining cellular responses in corticotrophs along hypothalamic-pituitary-adrenal axis.
  8. Here the authors demonstrate that mice lacking the alpha-tubulin acetyltransferase Atat1 in sensory neurons display profound deficits in their ability to detect mechanical stimuli.
    Title: Acetylated tubulin is essential for touch sensation in mice.
  9. alphaTAT1 has a conserved function as the major alpha-tubulin acetyltransferase in ciliated organisms and has an important role in regulating subcellular specialization of subsets of microtubules.
    Title: αTAT1 is the major α-tubulin acetyltransferase in mice.
  10. Data indicate that alpha-tubulin acetyltransferase 1 Atat1 is not required for survival and development but may regulate more advanced functions.
    Title: Mice lacking α-tubulin acetyltransferase 1 are viable but display α-tubulin acetylation deficiency and dentate gyrus distortion.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tubulin N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tubulin N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of NLRP3 inflammasome complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in alpha-tubulin acetylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within alpha-tubulin acetylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within alpha-tubulin acetylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dentate gyrus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of NLRP3 inflammasome complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule bundle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-tubulin N-acetyltransferase 1
Names
acetyltransferase mec-17 homolog
alpha-TAT
alpha-TAT1
NP_001136216.1
NP_001136217.1
NP_001334307.1
NP_001344794.1
NP_082752.3
XP_036016697.1
XP_036016698.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142744.1 → NP_001136216.1  alpha-tubulin N-acetyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_001136216.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). It should be noted that this variant contains an overlapping upstream ORF that may interfere with the translation of the annotated CDS.
    Source sequence(s)
    AK011750, AK133694, BB857404, BQ748472
    Consensus CDS
    CCDS50096.1
    UniProtKB/Swiss-Prot
    B8JJ75, B8JJ77, Q3UZR9, Q8BM67, Q8C1D1, Q8K2M7, Q8K341
    Related
    ENSMUSP00000056383.6, ENSMUST00000061052.12
    Conserved Domains (1) summary
    pfam05301
    Location:79 → 190
    Mec-17; Touch receptor neuron protein Mec-17

  2. NM_001142745.1 → NP_001136217.1  alpha-tubulin N-acetyltransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_001136217.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a few of 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (2) has a shorter and different C-terminus, as compared to isoform 1. It should be noted that this variant contains an overlapping upstream ORF that may interfere with the translation of the annotated CDS.
    Source sequence(s)
    AK133694, BB857404, CX223131
    Consensus CDS
    CCDS50097.1
    UniProtKB/Swiss-Prot
    Q8K341
    Related
    ENSMUSP00000115004.2, ENSMUST00000141662.8
    Conserved Domains (2) summary
    pfam05301
    Location:10 → 190
    Acetyltransf_16; GNAT acetyltransferase, Mec-17
    pfam08580
    Location:143 → 324
    KAR9; Yeast cortical protein KAR9

  3. NM_001347378.1 → NP_001334307.1  alpha-tubulin N-acetyltransferase 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    BQ748472, CR974451
    Consensus CDS
    CCDS84305.1
    UniProtKB/Swiss-Prot
    Q8K341
    Related
    ENSMUSP00000076703.7, ENSMUST00000077494.13

  4. NM_001357865.1 → NP_001344794.1  alpha-tubulin N-acetyltransferase 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AK028297, BB857404, BC030669, BQ748472
    Consensus CDS
    CCDS89088.1
    Related
    ENSMUSP00000122715.2, ENSMUST00000149277.8
    Conserved Domains (2) summary
    PHA03378
    Location:195 → 305
    PHA03378; EBNA-3B; Provisional
    pfam05301
    Location:10 → 190
    Acetyltransf_16; GNAT acetyltransferase, Mec-17

  5. NM_028476.4 → NP_082752.3  alpha-tubulin N-acetyltransferase 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal in-frame coding exon and a few of 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (3) lacks an internal segment and has a shorter and different C-terminus, as compared to isoform 1. It should be noted that this variant contains an overlapping upstream ORF that may interfere with the translation of the annotated CDS.
    Source sequence(s)
    AK049682, BB857404, CX223131
    Consensus CDS
    CCDS28711.1
    UniProtKB/Swiss-Prot
    Q8K341
    Related
    ENSMUSP00000053853.7, ENSMUST00000056034.13
    Conserved Domains (1) summary
    pfam05301
    Location:79 → 190
    Mec-17; Touch receptor neuron protein Mec-17

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    36208487..36220971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160804.1 → XP_036016697.1  alpha-tubulin N-acetyltransferase 1 isoform X1

    Conserved Domains (2) summary
    PHA03378
    Location:195 → 305
    PHA03378; EBNA-3B; Provisional
    pfam05301
    Location:10 → 190
    Acetyltransf_16; GNAT acetyltransferase, Mec-17

  2. XM_036160805.1 → XP_036016698.1  alpha-tubulin N-acetyltransferase 1 isoform X2

    Conserved Domains (1) summary
    pfam05301
    Location:10 → 190
    Acetyltransf_16; GNAT acetyltransferase, Mec-17

RNA

  1. XR_004939589.1 RNA Sequence

  2. XR_004939588.1 RNA Sequence

  3. XR_004939587.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K341.1 GenPept UniProtKB/Swiss-Prot:Q8K341

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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