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Sppl2b signal peptide peptidase like 2B [ Mus musculus (house mouse) ]

Gene ID: 73218, updated on 22-Apr-2024

Summary

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Official Symbol
Sppl2bprovided by MGI
Official Full Name
signal peptide peptidase like 2Bprovided by MGI
Primary source
MGI:MGI:1920468
See related
Ensembl:ENSMUSG00000035206 AllianceGenome:MGI:1920468
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PSL1; 3110056O03Rik
Summary
Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Predicted to be involved in membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; and regulation of immune response. Predicted to be located in several cellular components, including cytoskeleton; endosome membrane; and nucleoplasm. Predicted to be active in Golgi-associated vesicle membrane and lysosomal membrane. Predicted to be integral component of cytoplasmic side of endoplasmic reticulum membrane and integral component of lumenal side of endoplasmic reticulum membrane. Is expressed in embryo. Orthologous to human SPPL2B (signal peptide peptidase like 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 48.2), testis adult (RPKM 46.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80691067..80704542)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80855242..80868708)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat and Ig domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E11447 Neighboring gene STARR-positive B cell enhancer ABC_E6885 Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene transmembrane protease, serine 9 Neighboring gene translocase of inner mitochondrial membrane 13 Neighboring gene lamin B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The intramembrane proteases SPPL2a and SPPL2b regulate the homeostasis of selected SNARE proteins. Ballin M, et al. FEBS J, 2023 May. PMID 36047592
  2. The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo. Schneppenheim J, et al. Mol Cell Biol, 2014 Apr. PMID 24492962, Free PMC Article
  3. Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis. Mentrup T, et al. J Exp Med, 2019 Apr 1. PMID 30819724, Free PMC Article
  4. Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail. Behnke J, et al. FEBS Lett, 2011 Oct 3. PMID 21896273
  5. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Abeta-dependent expression in Alzheimer's disease.
    Title: Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer's disease.
  2. The intramembrane proteases SPPL2a and SPPL2b regulate the homeostasis of selected SNARE proteins.
    Title: The intramembrane proteases SPPL2a and SPPL2b regulate the homeostasis of selected SNARE proteins.
  3. SPPL2a/b negatively regulates LOX-1 signaling and atherosclerosis.
    Title: Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis.
  4. in vivo SPPL2a, but not SPPL2b, exhibit a physiologically relevant contribution to CD74 proteolysis in B and dendritic cells
    Title: The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane protein intracellular domain proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane protein proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane protein proteolysis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of immune response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi-associated vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi-associated vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic side of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in lumenal side of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lumenal side of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
signal peptide peptidase-like 2B
Names
protein SPP-like 2B
protein SPPL2b
NP_001345732.1
NP_001345733.1
NP_780404.2
XP_006514272.1
XP_006514273.1
XP_006514274.1
XP_006514275.1
XP_006514276.1
XP_011241887.1
XP_017169608.1
XP_030101169.1
XP_030101170.1
XP_030101171.1
XP_030101172.1
XP_030101173.1
XP_030101174.1
XP_036011937.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358803.1 → NP_001345732.1  signal peptide peptidase-like 2B isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC166937, AK148109, BB848740, BC052094, CK389382
    Conserved Domains (2) summary
    cd02129
    Location:38 → 157
    PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
    pfam04258
    Location:207 → 499
    Peptidase_A22B; Signal peptide peptidase

  2. NM_001358804.1 → NP_001345733.1  signal peptide peptidase-like 2B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK148109, BC052094
    Conserved Domains (1) summary
    cl01342
    Location:1 → 209
    Peptidase_A22B; Signal peptide peptidase

  3. NM_175195.3 → NP_780404.2  signal peptide peptidase-like 2B isoform 1 precursor

    See identical proteins and their annotated locations for NP_780404.2

    Status: VALIDATED

    Source sequence(s)
    AK148109, BB848740, BC052094
    Consensus CDS
    CCDS35988.1
    UniProtKB/Swiss-Prot
    Q3TD49, Q3TLQ8, Q3UG60, Q80VZ6
    Related
    ENSMUSP00000036289.9, ENSMUST00000035597.10
    Conserved Domains (2) summary
    cd02129
    Location:38 → 157
    PA_hSPPL_like; PA_hSPPL_like: Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the ...
    pfam04258
    Location:206 → 498
    Peptidase_A22B; Signal peptide peptidase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80691067..80704542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245311.2 → XP_030101171.1  signal peptide peptidase-like 2B isoform X10

    Conserved Domains (2) summary
    cd02129
    Location:38 → 157
    PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
    pfam04258
    Location:206 → 498
    Peptidase_A22B; Signal peptide peptidase

  2. XM_030245312.2 → XP_030101172.1  signal peptide peptidase-like 2B isoform X10

    Conserved Domains (2) summary
    cd02129
    Location:38 → 157
    PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
    pfam04258
    Location:206 → 498
    Peptidase_A22B; Signal peptide peptidase

  3. XM_006514210.4 → XP_006514273.1  signal peptide peptidase-like 2B isoform X3

    Conserved Domains (3) summary
    PRK14666
    Location:491 → 573
    uvrC; excinuclease ABC subunit C; Provisional
    cd02129
    Location:38 → 157
    PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
    pfam04258
    Location:206 → 498
    Peptidase_A22B; Signal peptide peptidase

  4. XM_030245310.2 → XP_030101170.1  signal peptide peptidase-like 2B isoform X9

    Conserved Domains (2) summary
    cd02129
    Location:38 → 157
    PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
    pfam04258
    Location:207 → 499
    Peptidase_A22B; Signal peptide peptidase

  5. XM_006514212.4 → XP_006514275.1  signal peptide peptidase-like 2B isoform X6

    See identical proteins and their annotated locations for XP_006514275.1

    Conserved Domains (2) summary
    cd02129
    Location:38 → 157
    PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
    pfam04258
    Location:207 → 499
    Peptidase_A22B; Signal peptide peptidase

  6. XM_006514209.4 → XP_006514272.1  signal peptide peptidase-like 2B isoform X1

    See identical proteins and their annotated locations for XP_006514272.1

    Conserved Domains (2) summary
    cd02129
    Location:38 → 157
    PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
    pfam04258
    Location:207 → 499
    Peptidase_A22B; Signal peptide peptidase

  7. XM_017314119.3 → XP_017169608.1  signal peptide peptidase-like 2B isoform X2

    Conserved Domains (3) summary
    PRK14666
    Location:492 → 574
    uvrC; excinuclease ABC subunit C; Provisional
    cd02129
    Location:38 → 157
    PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
    pfam04258
    Location:207 → 499
    Peptidase_A22B; Signal peptide peptidase

  8. XM_006514211.5 → XP_006514274.1  signal peptide peptidase-like 2B isoform X4

    Conserved Domains (2) summary
    cd02129
    Location:38 → 157
    PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
    pfam04258
    Location:207 → 460
    Peptidase_A22B; Signal peptide peptidase

  9. XM_011243585.4 → XP_011241887.1  signal peptide peptidase-like 2B isoform X5

    Conserved Domains (2) summary
    cd02129
    Location:38 → 157
    PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
    pfam04258
    Location:206 → 459
    Peptidase_A22B; Signal peptide peptidase

  10. XM_006514213.5 → XP_006514276.1  signal peptide peptidase-like 2B isoform X7

    Conserved Domains (2) summary
    pfam04258
    Location:146 → 438
    Peptidase_A22B; Signal peptide peptidase
    cl28883
    Location:38 → 96
    PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...

  11. XM_030245309.2 → XP_030101169.1  signal peptide peptidase-like 2B isoform X8

    Conserved Domains (2) summary
    pfam04258
    Location:145 → 437
    Peptidase_A22B; Signal peptide peptidase
    cl28883
    Location:38 → 96
    PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...

  12. XM_030245314.2 → XP_030101174.1  signal peptide peptidase-like 2B isoform X12

    Conserved Domains (1) summary
    cl01342
    Location:1 → 209
    Peptidase_A22B; Signal peptide peptidase

  13. XM_036156044.1 → XP_036011937.1  signal peptide peptidase-like 2B isoform X11

    UniProtKB/TrEMBL
    Q8BXJ5
    Conserved Domains (1) summary
    pfam04258
    Location:54 → 346
    Peptidase_A22B; Signal peptide peptidase

  14. XM_030245313.1 → XP_030101173.1  signal peptide peptidase-like 2B isoform X11

    UniProtKB/TrEMBL
    Q8BXJ5
    Conserved Domains (1) summary
    pfam04258
    Location:54 → 346
    Peptidase_A22B; Signal peptide peptidase

RNA

  1. XR_004936292.1 RNA Sequence

  2. XR_004936291.1 RNA Sequence

  3. XR_003948809.2 RNA Sequence

  4. XR_004936293.1 RNA Sequence

  5. XR_003948810.2 RNA Sequence

  6. XR_004936290.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TD49.2 GenPept UniProtKB/Swiss-Prot:Q3TD49

Gene LinkOut

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