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Xpot exportin, tRNA (nuclear export receptor for tRNAs) [ Mus musculus (house mouse) ]

Gene ID: 73192, updated on 11-Apr-2024

Summary

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Official Symbol
Xpotprovided by MGI
Official Full Name
exportin, tRNA (nuclear export receptor for tRNAs)provided by MGI
Primary source
MGI:MGI:1920442
See related
Ensembl:ENSMUSG00000034667 AllianceGenome:MGI:1920442
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EXPORTIN-T; 1110004L07Rik; 3110065H13Rik
Summary
Predicted to enable tRNA binding activity. Predicted to be involved in tRNA re-export from nucleus. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm and nuclear matrix. Is expressed in endocrine gland; female reproductive system; mammary gland; peripheral nervous system; and trigeminal nerve. Orthologous to human XPOT (exportin for tRNA). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 13.2), liver E14 (RPKM 10.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 D2; 10 69.86 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (121423285..121462411, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (121587380..121626506, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35696 Neighboring gene TANK-binding kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E1129 Neighboring gene STARR-positive B cell enhancer ABC_E9355 Neighboring gene STARR-seq mESC enhancer starr_28102 Neighboring gene predicted gene, 35816 Neighboring gene RIKEN cDNA D930020B18 gene Neighboring gene STARR-seq mESC enhancer starr_28105 Neighboring gene predicted gene, 35865

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis. Li Y, et al. Blood, 2021 Dec 9. PMID 34255829, Free PMC Article
  2. Quantitative trait loci for body size components in mice. Kenney-Hunt JP, et al. Mamm Genome, 2006 Jun. PMID 16783635
  3. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
  4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA re-export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
exportin-T
Names
exportin(tRNA)
tRNA exportin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081056.3 → NP_001074525.1  exportin-T isoform 1

    See identical proteins and their annotated locations for NP_001074525.1

    Status: VALIDATED

    Source sequence(s)
    AC124413, AC124992
    Consensus CDS
    CCDS88093.1
    UniProtKB/Swiss-Prot
    Q52KI1, Q9CRT8
    UniProtKB/TrEMBL
    A0A1W2P7Q6
    Related
    ENSMUSP00000151722.2, ENSMUST00000218004.2
    Conserved Domains (2) summary
    smart00913
    Location:21 → 88
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:100 → 247
    Xpo1; Exportin 1-like protein

  2. NM_001359618.2 → NP_001346547.1  exportin-T isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124413, AC124992
    Consensus CDS
    CCDS88093.1
    UniProtKB/Swiss-Prot
    Q52KI1, Q9CRT8
    UniProtKB/TrEMBL
    A0A1W2P7Q6
    Conserved Domains (2) summary
    smart00913
    Location:21 → 88
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:100 → 247
    Xpo1; Exportin 1-like protein

  3. NM_001401044.1 → NP_001387973.1  exportin-T isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124413, AC124992

  4. NM_001401045.1 → NP_001387974.1  exportin-T isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124413, AC124992

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    121423285..121462411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245308.1 → XP_030101168.1  exportin-T isoform X3

    UniProtKB/Swiss-Prot
    Q52KI1, Q9CRT8
    Conserved Domains (1) summary
    pfam08389
    Location:6 → 137
    Xpo1; Exportin 1-like protein

  2. XM_006514208.5 → XP_006514271.1  exportin-T isoform X3

    UniProtKB/Swiss-Prot
    Q52KI1, Q9CRT8
    Conserved Domains (1) summary
    pfam08389
    Location:6 → 137
    Xpo1; Exportin 1-like protein

  3. XM_030245306.2 → XP_030101166.1  exportin-T isoform X1

    UniProtKB/Swiss-Prot
    Q52KI1, Q9CRT8
    Conserved Domains (2) summary
    smart00913
    Location:21 → 88
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:98 → 245
    Xpo1; Exportin 1-like protein

  4. XM_006514206.4 → XP_006514269.1  exportin-T isoform X1

    UniProtKB/Swiss-Prot
    Q52KI1, Q9CRT8
    Conserved Domains (2) summary
    smart00913
    Location:21 → 88
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:98 → 245
    Xpo1; Exportin 1-like protein

  5. XM_006514207.5 → XP_006514270.1  exportin-T isoform X2

    UniProtKB/Swiss-Prot
    Q52KI1, Q9CRT8
    Conserved Domains (2) summary
    smart00913
    Location:21 → 88
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:100 → 247
    Xpo1; Exportin 1-like protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CRT8.3 GenPept UniProtKB/Swiss-Prot:Q9CRT8

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