Pear1 platelet endothelial aggregation receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pear1provided by MGI
Official Full Name: platelet endothelial aggregation receptor 1provided by MGI
Primary source: MGI:MGI:1920432
See related: Ensembl:ENSMUSG00000028073 AllianceGenome:MGI:1920432
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Jedi-1; Megf12; 3110045G13Rik
Summary: Enables signaling receptor activity. Involved in phosphatidylinositol 3-kinase signaling; platelet aggregation; and protein kinase B signaling. Acts upstream of or within recognition of apoptotic cell. Located in phagocytic cup. Is active in plasma membrane. Is expressed in brain; dorsal root ganglion; embryo; and heart. Orthologous to human PEAR1 (platelet endothelial aggregation receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 34.7), mammary gland adult (RPKM 30.0) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 38.5 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (87656404..87676262, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (87749097..87769110, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Jedi-1/MEGF12-mediated phagocytosis controls the pro-neurogenic properties of microglia in the ventricular-subventricular zone.
Title: Jedi-1/MEGF12-mediated phagocytosis controls the pro-neurogenic properties of microglia in the ventricular-subventricular zone.
SVEP1 is an endogenous ligand for the orphan receptor PEAR1.
Title: SVEP1 is an endogenous ligand for the orphan receptor PEAR1.
PEAR1 acts as a negative regulator in the proliferation of pulmonary microvascular endothelial cells in acute lung injury model via the PI3K/AKT pathway.
Title: PEAR1 suppresses the proliferation of pulmonary microvascular endothelial cells via PI3K/AKT pathway in ALI model.
These results provide new insight into the expression pattern of Jedi-1 in the peripheral nervous system and indicate that loss of Jedi-1 alters DRG neuron activity indirectly through an intercellular interaction between non-neuronal cells and sensory neurons.
Title: Jedi-1 deficiency increases sensory neuron excitability through a non-cell autonomous mechanism.
Results establish PEAR1 as the major signaling receptor for natural fucose-based polysaccharides and synthetic glycopolymers in human, but not in mouse, platelets.
Title: Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα.
Expression of the myogenic markers Desmin, MYOG, and MYH2 revealed that PEAR1 positively regulated C2C12 cell differentiation
Title: Platelet endothelial aggregation receptor-1 (PEAR1) is involved in C2C12 myoblast differentiation.
Platelet endothelial aggregation receptor-1: a novel modifier of neoangiogenesis.
Title: Platelet endothelial aggregation receptor-1: a novel modifier of neoangiogenesis.
Jedi-1 signals through recruitment of GULP, which promotes phagocytosis through a noncanonical phosphoclathrin-dependent mechanism.
Title: The adaptor protein GULP promotes Jedi-1-mediated phagocytosis through a clathrin-dependent mechanism.
These results indicated that both Jedi-1 and MEGF10 can mediate phagocytosis independently through the recruitment of Syk.
Title: Jedi-1 and MEGF10 signal engulfment of apoptotic neurons through the tyrosine kinase Syk.
a cellular and molecular mechanism by which neuronal corpses are culled during dorsal root ganglia development involves Jedi protein
Title: Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in platelet aggregation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of platelet activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of platelet activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within recognition of apoptotic cell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within recognition of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic cup	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: platelet endothelial aggregation receptor 1

Names: Jedi; jagged and Delta protein; mPEAR1; multiple EGF-like domains protein 12; multiple epidermal growth factor-like domains protein 12; protein Jedi

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001032413.1 → NP_001027585.1 platelet endothelial aggregation receptor 1 isoform a precursor

See identical proteins and their annotated locations for NP_001027585.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a).

Source sequence(s)

AC122439, AK053551, BB848869

Consensus CDS

CCDS38474.1

UniProtKB/Swiss-Prot

Q3URX7, Q6KAQ6, Q8CGA7, Q8VHF4, Q8VHL7, Q8VIK5

Related

ENSMUSP00000133323.2, ENSMUST00000174759.8

Conserved Domains (2) summary

pfam07546
Location:25 → 93

EMI; EMI domain

cl21504
Location:535 → 580

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
NM_001032414.1 → NP_001027586.1 platelet endothelial aggregation receptor 1 isoform a precursor

See identical proteins and their annotated locations for NP_001027586.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a).

Source sequence(s)

AC122439, AF440279, AK014179, BB848869

Consensus CDS

CCDS38474.1

UniProtKB/Swiss-Prot

Q3URX7, Q6KAQ6, Q8CGA7, Q8VHF4, Q8VHL7, Q8VIK5

Related

ENSMUSP00000078090.6, ENSMUST00000079083.12

Conserved Domains (2) summary

pfam07546
Location:25 → 93

EMI; EMI domain

cl21504
Location:535 → 580

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
NM_001289600.1 → NP_001276529.1 platelet endothelial aggregation receptor 1 isoform b

See identical proteins and their annotated locations for NP_001276529.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice junction at the 5' end of an exon, which causes translation initiation at an alternate start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.

Source sequence(s)

AC161454, AK141082, BB848869

UniProtKB/Swiss-Prot

Q8VIK5

Conserved Domains (1) summary

cl21504
Location:456 → 501

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
NM_001289601.1 → NP_001276530.1 platelet endothelial aggregation receptor 1 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (6) has several internal differences, which causes translation initiation at an alternate start codon, compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.

Source sequence(s)

AC161454, AK141082, AK161049, BB848869

UniProtKB/Swiss-Prot

Q8VIK5

Conserved Domains (2) summary

NF033759
Location:171 → 369

exchanger_TraA; outer membrane exchange protein TraA

cl21504
Location:283 → 328

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
NM_028460.2 → NP_082736.1 platelet endothelial aggregation receptor 1 isoform a precursor

See identical proteins and their annotated locations for NP_082736.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, 3, and 4 all encode the same isoform (a).

Source sequence(s)

AC122439, AF440279, BB848869

Consensus CDS

CCDS38474.1

UniProtKB/Swiss-Prot

Q3URX7, Q6KAQ6, Q8CGA7, Q8VHF4, Q8VHL7, Q8VIK5

Related

ENSMUSP00000133474.2, ENSMUST00000172621.8

Conserved Domains (2) summary

pfam07546
Location:25 → 93

EMI; EMI domain

cl21504
Location:535 → 580

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
NM_152799.2 → NP_690012.2 platelet endothelial aggregation receptor 1 isoform a precursor

See identical proteins and their annotated locations for NP_690012.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a).

Source sequence(s)

AC122439, AF440279, BB848869, BY236825

Consensus CDS

CCDS38474.1

UniProtKB/Swiss-Prot

Q3URX7, Q6KAQ6, Q8CGA7, Q8VHF4, Q8VHL7, Q8VIK5

Conserved Domains (2) summary

pfam07546
Location:25 → 93

EMI; EMI domain

cl21504
Location:535 → 580

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

87656404..87676262 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163352.1 → XP_036019245.1 platelet endothelial aggregation receptor 1 isoform X1

Conserved Domains (2) summary

NF033759
Location:171 → 369

exchanger_TraA; outer membrane exchange protein TraA

cl21504
Location:283 → 328

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...