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Tbkbp1 TBK1 binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 73174, updated on 5-Mar-2024

Summary

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Official Symbol
Tbkbp1provided by MGI
Official Full Name
TBK1 binding protein 1provided by MGI
Primary source
MGI:MGI:1920424
See related
Ensembl:ENSMUSG00000038517 AllianceGenome:MGI:1920424
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SINTBAD; ProSAPiP2; 3110043L15Rik
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in I-kappaB kinase/NF-kappaB signaling. Predicted to act upstream of or within innate immune response. Predicted to be active in cytoplasm. Is expressed in brown fat; genitourinary system; and nervous system. Orthologous to human TBKBP1 (TBK1 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 13.5), limb E14.5 (RPKM 11.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 60.95 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97026997..97042332, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97136171..97151506, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 7 Neighboring gene microRNA 8103 Neighboring gene STARR-seq mESC enhancer starr_30581 Neighboring gene T-box 21 Neighboring gene STARR-positive B cell enhancer ABC_E8446 Neighboring gene STARR-positive B cell enhancer ABC_E8447 Neighboring gene microRNA 7235 Neighboring gene karyopherin subunit beta 1 Neighboring gene STARR-positive B cell enhancer ABC_E1842 Neighboring gene STARR-positive B cell enhancer ABC_E910 Neighboring gene aminopeptidase puromycin sensitive

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. Zhu L, et al. Nat Commun, 2018 Jul 18. PMID 30022064, Free PMC Article
  2. TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis. Zhu L, et al. Nat Cell Biol, 2019 Dec. PMID 31792381, Free PMC Article
  3. The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response. Soulat D, et al. EMBO J, 2008 Aug 6. PMID 18583960, Free PMC Article
  4. SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK. Ryzhakov G, et al. EMBO J, 2007 Jul 11. PMID 17568778, Free PMC Article
  5. Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation. Fukasaka M, et al. J Immunol, 2013 Jun 1. PMID 23610142

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SINTBAD regulates IL-15-induced autophagy and NKT cell survival.
    Title: TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival.
  2. results suggest that efficient signal transduction upon viral infection requires SINTBAD, TANK and NAP1 because they link TBK1 and IKKi to virus-activated signalling cascades
    Title: SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TANK-binding kinase 1-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372527.1 → NP_001359456.1  TANK-binding kinase 1-binding protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL627445
    Consensus CDS
    CCDS48895.1
    UniProtKB/TrEMBL
    Z4YKN2
    Conserved Domains (2) summary
    TIGR02168
    Location:50 → 332
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam12845
    Location:289 → 341
    TBD; TBD domain

  2. NM_001372528.1 → NP_001359457.1  TANK-binding kinase 1-binding protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL627445
    Consensus CDS
    CCDS48895.1
    UniProtKB/TrEMBL
    Z4YKN2
    Conserved Domains (2) summary
    TIGR02168
    Location:50 → 332
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam12845
    Location:289 → 341
    TBD; TBD domain

  3. NM_001372529.1 → NP_001359458.1  TANK-binding kinase 1-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL627445
    Consensus CDS
    CCDS88239.1
    UniProtKB/Swiss-Prot
    A2A9S9, A2A9T0, Q6PFF1
    Conserved Domains (2) summary
    TIGR02168
    Location:53 → 341
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam12845
    Location:290 → 342
    TBD; TBD domain

  4. NM_001372530.1 → NP_001359459.1  TANK-binding kinase 1-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL627445
    Consensus CDS
    CCDS88239.1
    UniProtKB/Swiss-Prot
    A2A9S9, A2A9T0, Q6PFF1
    Related
    ENSMUSP00000103239.2, ENSMUST00000107614.8
    Conserved Domains (2) summary
    TIGR02168
    Location:53 → 341
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam12845
    Location:290 → 342
    TBD; TBD domain

  5. NM_001372531.1 → NP_001359460.1  TANK-binding kinase 1-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL627445
    Consensus CDS
    CCDS88239.1
    UniProtKB/Swiss-Prot
    A2A9S9, A2A9T0, Q6PFF1
    Related
    ENSMUSP00000065461.6, ENSMUST00000066078.12
    Conserved Domains (2) summary
    TIGR02168
    Location:53 → 341
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam12845
    Location:290 → 342
    TBD; TBD domain

  6. NM_198100.3 → NP_932768.2  TANK-binding kinase 1-binding protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL627445
    Consensus CDS
    CCDS48895.1
    UniProtKB/TrEMBL
    Z4YKN2
    Related
    ENSMUSP00000112396.2, ENSMUST00000118375.8
    Conserved Domains (2) summary
    TIGR02168
    Location:50 → 332
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam12845
    Location:289 → 341
    TBD; TBD domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97026997..97042332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534338.4 → XP_006534401.1  TANK-binding kinase 1-binding protein 1 isoform X1

    Conserved Domains (1) summary
    pfam12845
    Location:16 → 65
    TBD; TBD domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A9T0.1 GenPept UniProtKB/Swiss-Prot:A2A9T0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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