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Exo5 exonuclease 5 [ Mus musculus (house mouse) ]

Gene ID: 73172, updated on 5-Mar-2024

Summary

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Official Symbol
Exo5provided by MGI
Official Full Name
exonuclease 5provided by MGI
Primary source
MGI:MGI:1920422
See related
Ensembl:ENSMUSG00000028629 AllianceGenome:MGI:1920422
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dem1; Exo V; mExo5; 3110037I16Rik
Summary
Enables 4 iron, 4 sulfur cluster binding activity. Predicted to be involved in interstrand cross-link repair. Predicted to act upstream of or within DNA repair. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human EXO5 (exonuclease 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 11.6), CNS E14 (RPKM 10.8) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 56.65 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (120778399..120782202, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (120921202..120925005, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11258 Neighboring gene 60S ribosomal protein L26-like 1 pseudogene Neighboring gene predicted gene, 24678 Neighboring gene STARR-positive B cell enhancer ABC_E10254 Neighboring gene STARR-positive B cell enhancer ABC_E6207 Neighboring gene zinc finger protein 69 Neighboring gene STARR-positive B cell enhancer ABC_E6208 Neighboring gene STARR-positive B cell enhancer ABC_E4659 Neighboring gene small ArfGAP 2 Neighboring gene microRNA 7015

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Exonuclease 5 is dispensable for meiotic progression and male fertility in mouse. Zaman Q, et al. Gene, 2021 Feb 15. PMID 33164760
  2. Human exonuclease 5 is a novel sliding exonuclease required for genome stability. Sparks JL, et al. J Biol Chem, 2012 Dec 14. PMID 23095756, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA 5'-3' DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA 5'-3' DNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
exonuclease V
Names
defects in morphology 1 homolog
defects in morphology protein 1 homolog
probable exonuclease V

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160043.1 → NP_001153515.1  exonuclease V

    See identical proteins and their annotated locations for NP_001153515.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK014134, CA548348
    Consensus CDS
    CCDS18596.1
    UniProtKB/Swiss-Prot
    A2A767, A2A769, Q9CXP9
    Related
    ENSMUSP00000136408.2, ENSMUST00000177880.2
    Conserved Domains (1) summary
    pfam09810
    Location:72 → 355
    Exo5; Exonuclease V - a 5' deoxyribonuclease

  2. NM_028457.2 → NP_082733.1  exonuclease V

    See identical proteins and their annotated locations for NP_082733.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK014134, CA548348
    Consensus CDS
    CCDS18596.1
    UniProtKB/Swiss-Prot
    A2A767, A2A769, Q9CXP9
    Related
    ENSMUSP00000030375.3, ENSMUST00000030375.9
    Conserved Domains (1) summary
    pfam09810
    Location:72 → 355
    Exo5; Exonuclease V - a 5' deoxyribonuclease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    120778399..120782202 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXP9.1 GenPept UniProtKB/Swiss-Prot:Q9CXP9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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