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Cenpv centromere protein V [ Mus musculus (house mouse) ]

Gene ID: 73139, updated on 5-Mar-2024

Summary

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Official Symbol
Cenpvprovided by MGI
Official Full Name
centromere protein Vprovided by MGI
Primary source
MGI:MGI:1920389
See related
Ensembl:ENSMUSG00000018509 AllianceGenome:MGI:1920389
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prr6; 3110013H01Rik
Summary
Predicted to enable carbon-sulfur lyase activity and metal ion binding activity. Predicted to be involved in pericentric heterochromatin assembly; positive regulation of cytokinesis; and regulation of chromosome organization. Predicted to act upstream of or within ameboidal-type cell migration. Predicted to be located in several cellular components, including microtubule cytoskeleton; midbody; and nucleus. Predicted to be active in kinetochore; nucleus; and spindle midzone. Orthologous to human CENPV (centromere protein V). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 146.5), duodenum adult (RPKM 37.7) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B2; 11 38.43 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62415770..62430695, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62524944..62539869, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 19 Neighboring gene nuclear receptor co-repressor 1 Neighboring gene STARR-seq mESC enhancer starr_29697 Neighboring gene STARR-seq mESC enhancer starr_29699 Neighboring gene STARR-seq mESC enhancer starr_29702 Neighboring gene STARR-seq mESC enhancer starr_29703 Neighboring gene STARR-seq mESC enhancer starr_29704 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class L Neighboring gene STARR-seq mESC enhancer starr_29710 Neighboring gene STARR-seq mESC enhancer starr_29712 Neighboring gene STARR-seq mESC enhancer starr_29713 Neighboring gene predicted gene 12279 Neighboring gene ubiquitin B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes. Nabi D, et al. Nat Commun, 2021 Nov 11. PMID 34764261, Free PMC Article
  2. CENP-V is required for centromere organization, chromosome alignment and cytokinesis. Tadeu AM, et al. EMBO J, 2008 Oct 8. PMID 18772885, Free PMC Article
  3. Identification of CENP-V as a novel microtubule-associating molecule that activates Src family kinases through SH3 domain interaction. Honda Z, et al. Genes Cells, 2009 Dec. PMID 19930468
  4. Proteomic analysis of the mammalian nuclear pore complex. Cronshaw JM, et al. J Cell Biol, 2002 Sep 2. PMID 12196509, Free PMC Article
  5. PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells. Illingworth RS, et al. PLoS One, 2012. PMID 22496869, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbon-sulfur lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ameboidal-type cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in centromere complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in pericentric heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pericentric heterochromatin formation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of chromosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of chromosome organization ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle midzone ISO
Inferred from Sequence Orthology
more info
  
located_in spindle midzone ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
centromere protein V
Names
CENP-V
proline-rich polypeptide 6
proline-rich protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028448.1 → NP_082724.1  centromere protein V

    See identical proteins and their annotated locations for NP_082724.1

    Status: VALIDATED

    Source sequence(s)
    AK014046, AL596181, BP771180
    Consensus CDS
    CCDS48818.1
    UniProtKB/Swiss-Prot
    B2RWK8, B9EK22, Q5SX21, Q6PIA5, Q9CXS4
    Related
    ENSMUSP00000018653.2, ENSMUST00000018653.8
    Conserved Domains (1) summary
    COG3791
    Location:124 → 220
    COG3791; Uncharacterized conserved protein [Function unknown]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    62415770..62430695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534333.3 → XP_006534396.1  centromere protein V isoform X1

    Conserved Domains (1) summary
    COG3791
    Location:14 → 110
    COG3791; Uncharacterized conserved protein [Function unknown]

RNA

  1. XR_001780064.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXS4.2 GenPept UniProtKB/Swiss-Prot:Q9CXS4

Gene LinkOut

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