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Golim4 golgi integral membrane protein 4 [ Mus musculus (house mouse) ]

Gene ID: 73124, updated on 11-Apr-2024

Summary

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Official Symbol
Golim4provided by MGI
Official Full Name
golgi integral membrane protein 4provided by MGI
Primary source
MGI:MGI:1920374
See related
Ensembl:ENSMUSG00000034109 AllianceGenome:MGI:1920374
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P138; GIMPC; GPP130; Golph4; 3110027H23Rik
Summary
Predicted to be located in Golgi membrane and endosome. Predicted to be active in Golgi apparatus. Predicted to be integral component of membrane. Is expressed in coronary artery. Orthologous to human GOLIM4 (golgi integral membrane protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 25.8), limb E14.5 (RPKM 15.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 E3; 3 33.76 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (75783490..75864256, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (75876183..75956956, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07971 Neighboring gene pluripotency associated transcript 10 Neighboring gene STARR-positive B cell enhancer ABC_E9553 Neighboring gene STARR-positive B cell enhancer mm9_chr3:75547372-75547672 Neighboring gene predicted gene, 25846 Neighboring gene STARR-seq mESC enhancer starr_07973 Neighboring gene STARR-positive B cell enhancer ABC_E11194 Neighboring gene STARR-positive B cell enhancer ABC_E1260 Neighboring gene STARR-positive B cell enhancer mm9_chr3:75805184-75805484 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene follistatin-like 5 Neighboring gene VISTA enhancer mm1370 Neighboring gene STARR-seq mESC enhancer starr_07975

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Segregation of NF-kappaB activation through NEMO/IKKgamma by Tax and TNFalpha: implications for stimulus-specific interruption of oncogenic signaling. Iha H, et al. Oncogene, 2003 Dec 4. PMID 14654787
  2. Pkd1 and Wnt5a genetically interact to control lymphatic vascular morphogenesis in mice. Chau TCY, et al. Dev Dyn, 2022 Feb. PMID 34174014
  3. Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow. Betterman KL, et al. J Clin Invest, 2020 Jun 1. PMID 32182215, Free PMC Article
  4. DACH1 stimulates shear stress-guided endothelial cell migration and coronary artery growth through the CXCL12-CXCR4 signaling axis. Chang AH, et al. Genes Dev, 2017 Jul 1. PMID 28779009, Free PMC Article
  5. Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation. Lutter S, et al. J Cell Biol, 2012 Jun 11. PMID 22665518, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102202

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Golgi integral membrane protein 4
Names
decapacitation factor 10
golgi phosphoprotein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291069.1 → NP_001277998.1  Golgi integral membrane protein 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC161369, AK078928
    Consensus CDS
    CCDS71251.1
    UniProtKB/TrEMBL
    D3YVW2
    Related
    ENSMUSP00000114006.2, ENSMUST00000117242.8
    Conserved Domains (1) summary
    cl23765
    Location:67 → 213
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  2. NM_175193.6 → NP_780402.1  Golgi integral membrane protein 4 isoform 2

    See identical proteins and their annotated locations for NP_780402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC161369, AC167173, BC086642
    Consensus CDS
    CCDS17416.1
    UniProtKB/Swiss-Prot
    Q8BWP9, Q8BXA1
    Related
    ENSMUSP00000048997.8, ENSMUST00000038563.14
    Conserved Domains (1) summary
    cl23720
    Location:113 → 214
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    75783490..75864256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BXA1.1 GenPept UniProtKB/Swiss-Prot:Q8BXA1

Gene LinkOut

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