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Prss57 serine protease 57 [ Mus musculus (house mouse) ]

Gene ID: 73106, updated on 21-Apr-2024

Summary

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Official Symbol
Prss57provided by MGI
Official Full Name
serine protease 57provided by MGI
Primary source
MGI:MGI:1920356
See related
Ensembl:ENSMUSG00000020323 AllianceGenome:MGI:1920356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NSP4; Prssl1; UNQ782; GLGL782; 2900092M14Rik
Summary
Predicted to enable heparin binding activity and serine-type peptidase activity. Predicted to be involved in proteolysis. Predicted to be located in azurophil granule lumen and extracellular space. Orthologous to human PRSS57 (serine protease 57). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 24.9), lung adult (RPKM 6.4) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79617308..79630523, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79781474..79794684, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 22 Neighboring gene ring finger protein 126 Neighboring gene STARR-positive B cell enhancer ABC_E899 Neighboring gene STARR-positive B cell enhancer ABC_E719 Neighboring gene follistatin-like 3 Neighboring gene paralemmin Neighboring gene predicted gene, 40713 Neighboring gene mitotic spindle positioning

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage. AhYoung AP, et al. Commun Biol, 2020 Nov 19. PMID 33214666, Free PMC Article
  2. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage.
    Title: Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in azurophil granule lumen ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine protease 57
Names
neutrophil serine protease 4
protease, serine 57
protease, serine-like 1
serine protease 1-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042710.1 → NP_001036175.1  serine protease 57 precursor

    See identical proteins and their annotated locations for NP_001036175.1

    Status: VALIDATED

    Source sequence(s)
    AC151828, AK158376
    Consensus CDS
    CCDS35968.1
    UniProtKB/Swiss-Prot
    Q14B24
    Related
    ENSMUSP00000020573.7, ENSMUST00000020573.13
    Conserved Domains (1) summary
    cd00190
    Location:40 → 264
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79617308..79630523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514199.5 → XP_006514262.1  serine protease 57 isoform X1

    See identical proteins and their annotated locations for XP_006514262.1

    UniProtKB/Swiss-Prot
    Q14B24
    Conserved Domains (1) summary
    cd00190
    Location:40 → 264
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. XM_036156043.1 → XP_036011936.1  serine protease 57 isoform X1

    UniProtKB/Swiss-Prot
    Q14B24
    Conserved Domains (1) summary
    cd00190
    Location:40 → 264
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. XM_011243584.4 → XP_011241886.1  serine protease 57 isoform X1

    See identical proteins and their annotated locations for XP_011241886.1

    UniProtKB/Swiss-Prot
    Q14B24
    Conserved Domains (1) summary
    cd00190
    Location:40 → 264
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  4. XM_006514201.5 → XP_006514264.1  serine protease 57 isoform X3

    Conserved Domains (1) summary
    cd00190
    Location:40 → 220
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  5. XM_006514200.5 → XP_006514263.1  serine protease 57 isoform X2

    Conserved Domains (1) summary
    cd00190
    Location:40 → 228
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  6. XM_006514202.5 → XP_006514265.1  serine protease 57 isoform X4

    Conserved Domains (1) summary
    cd00190
    Location:40 → 185
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14B24.2 GenPept UniProtKB/Swiss-Prot:Q14B24

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