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Slc22a23 solute carrier family 22, member 23 [ Mus musculus (house mouse) ]

Gene ID: 73102, updated on 5-Mar-2024

Summary

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Official Symbol
Slc22a23provided by MGI
Official Full Name
solute carrier family 22, member 23provided by MGI
Primary source
MGI:MGI:1920352
See related
Ensembl:ENSMUSG00000038267 AllianceGenome:MGI:1920352
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3110004L20Rik
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to act upstream of or within ion transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in blood vessel; branchial arch; embryo; heart; and outflow tract. Orthologous to human SLC22A23 (solute carrier family 22 member 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 22.2), kidney adult (RPKM 17.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A3.3; 13 14.05 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (34363141..34530666, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (34179158..34345275, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1605 Neighboring gene STARR-seq mESC enhancer starr_34140 Neighboring gene STARR-seq mESC enhancer starr_34143 Neighboring gene predicted gene, 36549 Neighboring gene STARR-seq mESC enhancer starr_34144 Neighboring gene proteasome (prosome, macropain) assembly chaperone 4 Neighboring gene STARR-seq mESC enhancer starr_34145 Neighboring gene STARR-seq mESC enhancer starr_34148 Neighboring gene VISTA enhancer mm1307 Neighboring gene predicted gene, 53791 Neighboring gene predicted gene 6129

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse ES cell-derived cardiac precursor cells are multipotent and facilitate identification of novel cardiac genes. Christoforou N, et al. J Clin Invest, 2008 Mar. PMID 18246200, Free PMC Article
  2. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. Jacobsson JA, et al. Genomics, 2007 Nov. PMID 17714910
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 22 member 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033167.3 → NP_001028339.1  solute carrier family 22 member 23 isoform 1

    See identical proteins and their annotated locations for NP_001028339.1

    Status: VALIDATED

    Source sequence(s)
    AC102087, AC129019, AC139242
    Consensus CDS
    CCDS26446.1
    UniProtKB/Swiss-Prot
    Q3UHH2, Q7TPT5
    UniProtKB/TrEMBL
    F7BP73
    Related
    ENSMUSP00000042742.6, ENSMUST00000040336.12
    Conserved Domains (2) summary
    cd06174
    Location:230 → 359
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:98 → 631
    2A0119; cation transport protein

  2. NM_001382849.1 → NP_001369778.1  solute carrier family 22 member 23 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102087, AC129019, AC139242
    UniProtKB/TrEMBL
    F7BP73
    Related
    ENSMUSP00000122283.2, ENSMUST00000148390.3
    Conserved Domains (1) summary
    cd17444
    Location:187 → 600
    MFS_SLC22A23; Solute carrier family 22, member 23 of the Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    34363141..34530666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247433.1 → XP_030103293.1  solute carrier family 22 member 23 isoform X1

    Conserved Domains (1) summary
    cl28910
    Location:134 → 485
    MFS; Major Facilitator Superfamily

  2. XM_030247434.2 → XP_030103294.1  solute carrier family 22 member 23 isoform X3

    Conserved Domains (1) summary
    cl28910
    Location:1 → 287
    MFS; Major Facilitator Superfamily

  3. XM_036158192.1 → XP_036014085.1  solute carrier family 22 member 23 isoform X2

    Conserved Domains (1) summary
    cl28910
    Location:187 → 359
    MFS; Major Facilitator Superfamily

RNA

  1. XR_004938073.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UHH2.1 GenPept UniProtKB/Swiss-Prot:Q3UHH2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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