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ZRSR2P1 ZRSR2 pseudogene 1 [ Homo sapiens (human) ]

Gene ID: 7310, updated on 23-Nov-2023

Summary

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Official Symbol
ZRSR2P1provided by HGNC
Official Full Name
ZRSR2 pseudogene 1provided by HGNC
Primary source
HGNC:HGNC:12456
See related
Ensembl:ENSG00000212643 MIM:601079; AllianceGenome:HGNC:12456
Gene type
pseudo
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZRSR1; U2AF1P; ZC3H21; U2AF1L1; U2AFBPL; U2AF1RS1; U2AF1-RS1
Summary
Predicted to enable pre-mRNA 3'-splice site binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U2AF complex and spliceosomal complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
5q22.2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (112891628..112893097)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (113402150..113403619)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (112227325..112228794)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene APC regulator of WNT signaling pathway Neighboring gene RNA, U6 small nuclear 482, pseudogene Neighboring gene Sharpr-MPRA regulatory region 9882 Neighboring gene signal recognition particle 19 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:112226954-112228153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16238 Neighboring gene receptor accessory protein 5 Neighboring gene X-box binding protein 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16240 Neighboring gene uncharacterized LOC105379123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22913 Neighboring gene MPRA-validated peak5421 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16241 Neighboring gene Sharpr-MPRA regulatory region 12983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22914 Neighboring gene uncharacterized LOC105379126

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identifying large indels in targeted next generation sequencing assays for myeloid neoplasms: a cautionary tale of the ZRSR1 pseudogene. Ng IK, et al. J Clin Pathol, 2017 Dec. PMID 28676493
  2. U2 small nuclear ribonucleoprotein particle (snRNP) auxiliary factor of 65 kDa, U2AF65, can promote U1 snRNP recruitment to 5' splice sites. Förch P, et al. Biochem J, 2003 May 15. PMID 12558503, Free PMC Article
  3. Absence of imprinting in U2AFBPL, a human homologue of the imprinted mouse gene U2afbp-rs. Pearsall RS, et al. Biochem Biophys Res Commun, 1996 May 6. PMID 8630064
  4. A case-by-case evolutionary analysis of four imprinted retrogenes. McCole RB, et al. Evolution, 2011 May. PMID 21166792, Free PMC Article
  5. Comparative analyses of genomic imprinting and CpG island-methylation in mouse Murr1 and human MURR1 loci revealed a putative imprinting control region in mice. Zhang Z, et al. Gene, 2006 Jan 17. PMID 16305817

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Confounding ZRSR1 pseudogene led to an erroneous ZRSR2 variant call in myeloid neoplasms.
    Title: Identifying large indels in targeted next generation sequencing assays for myeloid neoplasms: a cautionary tale of the ZRSR1 pseudogene.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • U2 small nuclear RNA auxillary factor 1-like 1
  • U2 small nuclear ribonucleoprotein auxiliary factor, small subunit 1
  • U2(RNU2) small nuclear RNA auxiliary factor pseudogene 1
  • zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1
  • zinc finger CCCH-type, RNA binding motif and serine/arginine rich 1

Clone Names

  • FLJ94140, MGC142159

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pre-mRNA 3'-splice site binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U2AF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_005419.5 

    Range
    101..1570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    112891628..112893097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    113402150..113403619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_005083.2: Suppressed sequence

    Description
    NM_005083.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15695.2 GenPept UniProtKB/Swiss-Prot:Q15695

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous