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Sgip1 SH3-domain GRB2-like (endophilin) interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 73094, updated on 21-Apr-2024

Summary

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Official Symbol
Sgip1provided by MGI
Official Full Name
SH3-domain GRB2-like (endophilin) interacting protein 1provided by MGI
Primary source
MGI:MGI:1920344
See related
Ensembl:ENSMUSG00000028524 AllianceGenome:MGI:1920344
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
gag; SGIP1alpha; 3110007P09Rik
Summary
Enables microtubule binding activity and phospholipid binding activity. Acts upstream of or within plasma membrane tubulation and positive regulation of receptor-mediated endocytosis. Located in clathrin-coated vesicle and plasma membrane. Part of AP-2 adaptor complex. Is expressed in central nervous system; metanephros; small intestine; and testis. Orthologous to human SGIP1 (SH3GL interacting endocytic adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 10.0), cortex adult (RPKM 5.5) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 C6; 4 47.09 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (102616351..102834623)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (102741302..102977426)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4B, cAMP specific Neighboring gene STARR-positive B cell enhancer ABC_E4639 Neighboring gene STARR-positive B cell enhancer ABC_E1034 Neighboring gene STARR-seq mESC enhancer starr_10927 Neighboring gene predicted gene, 52667 Neighboring gene predicted gene, 24869 Neighboring gene STARR-seq mESC enhancer starr_10929 Neighboring gene STARR-seq mESC enhancer starr_10931 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:102663627-102663912 Neighboring gene STARR-seq mESC enhancer starr_10932 Neighboring gene predicted gene 12709 Neighboring gene dynein light chain Tctex-type 5 Neighboring gene expressed sequence BB031773 Neighboring gene insulin-like 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SGIP1 is involved in regulation of emotionality, mood, and nociception and modulates in vivo signalling of cannabinoid CB(1) receptors. Dvorakova M, et al. Br J Pharmacol, 2021 Apr. PMID 33491188, Free PMC Article
  2. SGIP1α functions as a selective endocytic adaptor for the internalization of synaptotagmin 1 at synapses. Lee SE, et al. Mol Brain, 2019 May 3. PMID 31053155, Free PMC Article
  3. SGIP1 alters internalization and modulates signaling of activated cannabinoid receptor 1 in a biased manner. Hájková A, et al. Neuropharmacology, 2016 Aug. PMID 26970018
  4. Enhanced clathrin-dependent endocytosis in the absence of calnexin. Li HD, et al. PLoS One, 2011. PMID 21747946, Free PMC Article
  5. Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance. Trevaskis J, et al. Endocrinology, 2005 Sep. PMID 15919751

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Multiple Sgip1 splice variants inhibit cannabinoid receptor 1 internalization.
    Title: Multiple Sgip1 splice variants inhibit cannabinoid receptor 1 internalization.
  2. SGIP1alpha is an endocytic adaptor dedicated to the retrieval of surface-stranded Syt1.
    Title: SGIP1α functions as a selective endocytic adaptor for the internalization of synaptotagmin 1 at synapses.
  3. Study showed that SGIP1 prevents the endocytosis of activated CB1R and that it alters signaling via the CB1R in a biased manner. CB1R mediated G-protein activation is selectively influenced by SGIP1, beta-arrestin associated signaling is changed profoundly, most likely as a consequence of the prevention of the receptor's internalization elicited by SGIP1.
    Title: SGIP1 alters internalization and modulates signaling of activated cannabinoid receptor 1 in a biased manner.
  4. SGIP1 is an important and novel member of the group of neuronal molecules required for the regulation of energy homeostasis
    Title: Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in energy homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of eating behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in response to dietary excess ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle endocytosis IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of AP-2 adaptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SH3-containing GRB2-like protein 3-interacting protein 1
Names
SH3-domain GRB2-like interacting protein 1 alpha
endophilin-3-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285852.1 → NP_001272781.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK147926, AL732543, BY249204, BY617051
    UniProtKB/TrEMBL
    Q3UGH4
    Conserved Domains (1) summary
    cd09266
    Location:587 → 853
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  2. NM_001285859.1 → NP_001272788.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform c

    See identical proteins and their annotated locations for NP_001272788.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in both the 5' and central coding regions, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AK043018, AK147926, AL732543, BY249204, BY617051
    Consensus CDS
    CCDS71429.1
    UniProtKB/TrEMBL
    F7CPX0
    Related
    ENSMUSP00000063712.8, ENSMUST00000066824.14
    Conserved Domains (1) summary
    cd09266
    Location:392 → 658
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  3. NM_001285860.1 → NP_001272789.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 5' coding region, and also lacks two alternate in-frame exons in the central coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AK032439, AK147926, AL732543, BY249204, BY617051
    Consensus CDS
    CCDS71430.1
    UniProtKB/TrEMBL
    F7CPX0
    Related
    ENSMUSP00000072301.6, ENSMUST00000072481.12
    Conserved Domains (1) summary
    cd09266
    Location:372 → 638
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  4. NM_001285862.1 → NP_001272791.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks six alternate in-frame exons among the 5' and central coding regions, compared to variant 1, resulting in an isoform (e) that is shorter than isoform a.
    Source sequence(s)
    AK147926, AK148302, AL732543, BY249204, BY617051
    UniProtKB/TrEMBL
    F7CPX0
    Related
    ENSMUSP00000122556.2, ENSMUST00000149547.2
    Conserved Domains (1) summary
    cd09266
    Location:341 → 607
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  5. NM_144906.2 → NP_659155.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform b

    See identical proteins and their annotated locations for NP_659155.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in both the 5' and central coding regions, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AK147926, AL732543, BC017596, BY249204, BY617051
    Consensus CDS
    CCDS18404.1
    UniProtKB/Swiss-Prot
    A7BFW0, Q3UFU3, Q3UGA0, Q8BXX4, Q8C034, Q8VD37, Q9CXT2
    Related
    ENSMUSP00000079553.7, ENSMUST00000080728.13
    Conserved Domains (1) summary
    cd09266
    Location:539 → 805
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    102616351..102834623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164480.1 → XP_036020373.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X13

    UniProtKB/TrEMBL
    F7CPX0
    Conserved Domains (1) summary
    cd09266
    Location:364 → 630
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  2. XM_036164474.1 → XP_036020367.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1

    Conserved Domains (1) summary
    cd09266
    Location:589 → 855
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  3. XM_006503427.4 → XP_006503490.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X3

    Conserved Domains (1) summary
    cd09266
    Location:567 → 833
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  4. XM_036164475.1 → XP_036020368.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X2

    Conserved Domains (1) summary
    cd09266
    Location:581 → 847
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  5. XM_036164477.1 → XP_036020370.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X7

    UniProtKB/TrEMBL
    F7CPX0
    Conserved Domains (2) summary
    PHA03247
    Location:172 → 310
    PHA03247; large tegument protein UL36; Provisional
    cd09266
    Location:421 → 687
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  6. XM_017320403.2 → XP_017175892.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X8

    Conserved Domains (1) summary
    cd09266
    Location:401 → 667
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  7. XM_006503428.4 → XP_006503491.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X4

    UniProtKB/Swiss-Prot
    Q8VD37
    Related
    ENSMUSP00000102495.3, ENSMUST00000106882.9
    Conserved Domains (1) summary
    cd09266
    Location:559 → 825
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  8. XM_036164478.1 → XP_036020371.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X9

    UniProtKB/TrEMBL
    F7CPX0
    Conserved Domains (1) summary
    cd09266
    Location:387 → 653
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  9. XM_036164479.1 → XP_036020372.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X10

    UniProtKB/TrEMBL
    F7CPX0
    Conserved Domains (1) summary
    cd09266
    Location:385 → 651
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  10. XM_030253827.1 → XP_030109687.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X12

    UniProtKB/TrEMBL
    F7CPX0
    Conserved Domains (1) summary
    cd09266
    Location:365 → 631
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  11. XM_006503429.4 → XP_006503492.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X5

    Conserved Domains (1) summary
    cd09266
    Location:535 → 801
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  12. XM_036164476.1 → XP_036020369.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X6

    Conserved Domains (1) summary
    cd09266
    Location:515 → 781
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  13. XM_030253826.1 → XP_030109686.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X11

    UniProtKB/TrEMBL
    F7CPX0
    Conserved Domains (2) summary
    PHA03247
    Location:120 → 258
    PHA03247; large tegument protein UL36; Provisional
    cd09266
    Location:369 → 635
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  14. XM_036164481.1 → XP_036020374.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X14

    UniProtKB/TrEMBL
    F7CPX0
    Conserved Domains (1) summary
    cd09266
    Location:363 → 629
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  15. XM_036164482.1 → XP_036020375.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X15

    UniProtKB/TrEMBL
    F7CPX0
    Conserved Domains (1) summary
    cd09266
    Location:361 → 627
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

RNA

  1. XR_004941969.1 RNA Sequence

  2. XR_004941975.1 RNA Sequence

  3. XR_004941978.1 RNA Sequence

  4. XR_004941984.1 RNA Sequence

  5. XR_004941977.1 RNA Sequence

  6. XR_004941979.1 RNA Sequence

  7. XR_004941970.1 RNA Sequence

  8. XR_004941976.1 RNA Sequence

  9. XR_004941980.1 RNA Sequence

  10. XR_004941987.1 RNA Sequence

  11. XR_004941972.1 RNA Sequence

  12. XR_376364.4 RNA Sequence

  13. XR_004941973.1 RNA Sequence

  14. XR_376362.4 RNA Sequence

  15. XR_004941982.1 RNA Sequence

  16. XR_376369.4 RNA Sequence

  17. XR_004941983.1 RNA Sequence

  18. XR_004941974.1 RNA Sequence

  19. XR_376370.4 RNA Sequence

  20. XR_004941971.1 RNA Sequence

  21. XR_004941985.1 RNA Sequence

  22. XR_004941989.1 RNA Sequence

  23. XR_004941990.1 RNA Sequence

  24. XR_004941981.1 RNA Sequence

  25. XR_004941986.1 RNA Sequence

  26. XR_003955027.1 RNA Sequence

  27. XR_004941988.1 RNA Sequence

  28. XR_004941991.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VD37.1 GenPept UniProtKB/Swiss-Prot:Q8VD37

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