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LOC730101 uncharacterized LOC730101 [ Homo sapiens (human) ]

Gene ID: 730101, updated on 10-Oct-2023

Summary

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Gene symbol
LOC730101
Gene description
uncharacterized LOC730101
See related
Ensembl:ENSG00000291006
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in placenta (RPKM 10.4), duodenum (RPKM 5.9) and 23 other tissues See more
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Genomic context

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Location:
6p12.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (52664401..52669153)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (52503141..52507893)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52529199..52533951)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901330 Neighboring gene SH3 domain binding glutamate rich protein like 3 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24687 Neighboring gene Sharpr-MPRA regulatory region 5928 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:52535127-52535627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24689 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:52540056-52540616 Neighboring gene transmembrane protein 14A Neighboring gene SREK1IP1 pseudogene 2 Neighboring gene glutathione S-transferase alpha 8, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High expression of long non-coding RNA LOC730101 correlates with distant metastasis and exhibits a poor prognosis in patients with osteosarcoma. Li SW, et al. Eur Rev Med Pharmacol Sci, 2018 Jul. PMID 30024599
  2. LncRNA LOC730101 promotes osteosarcoma cell survival under energy stress. Cheng G, et al. Biochem Biophys Res Commun, 2018 Jan 29. PMID 29253564
  3. Highly expressed lncRNA LOC730101 promotes lung cancer cell growth through Wnt canonical pathway. Liu L, et al. Biochem Biophys Res Commun, 2017 Nov 18. PMID 28943432
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LOC730101 was significantly upregulated in human osteosarcoma tissues compared with corresponding adjacent normal tissues; elevated LOC730101 expression was correlated with advanced clinical stage and distant metastasis
    Title: High expression of long non-coding RNA LOC730101 correlates with distant metastasis and exhibits a poor prognosis in patients with osteosarcoma.
  2. Taken together, our findings enlarged the knowledge about the roles of LOC730101 in osteosarcoma progression.
    Title: LncRNA LOC730101 promotes osteosarcoma cell survival under energy stress.
  3. Overexpression of LOC730101 prompted the proliferation of non-small-cell lung cancer both in vitro and in vivo while Silencing observed opposite phenomenon.
    Title: Highly expressed lncRNA LOC730101 promotes lung cancer cell growth through Wnt canonical pathway.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Clone Names

  • FLJ33798, FLJ38040, FLJ38488, DKFZp566E183

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_024403.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AL109918
    Related
    ENST00000602367.2

  2. NR_024405.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal segment compared to variant 1.
    Source sequence(s)
    AL109918
    Related
    ENST00000643631.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    52664401..52669153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    52503141..52507893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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