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Tmem138 transmembrane protein 138 [ Mus musculus (house mouse) ]

Gene ID: 72982, updated on 5-Mar-2024

Summary

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Official Symbol
Tmem138provided by MGI
Official Full Name
transmembrane protein 138provided by MGI
Primary source
MGI:MGI:1920232
See related
Ensembl:ENSMUSG00000024666 AllianceGenome:MGI:1920232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700113I01Rik; 2900055D14Rik
Summary
Predicted to be involved in cilium assembly. Predicted to act upstream of or within cell projection organization. Predicted to be located in cell projection; membrane; and vacuole. Predicted to be integral component of membrane. Predicted to be active in cilium. Is expressed in several structures, including 4th ventricle choroid plexus; brain ventricular layer; choroid invagination; genitourinary system; and gut gland. Human ortholog(s) of this gene implicated in Joubert syndrome 16. Orthologous to human TMEM138 (transmembrane protein 138). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 6.9), CNS E11.5 (RPKM 6.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 6.6 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10547842..10554765, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10570478..10577386, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene succinate dehydrogenase complex assembly factor 2 Neighboring gene cleavage and polyadenylation specific factor 7 Neighboring gene transmembrane protein 216 Neighboring gene STARR-positive B cell enhancer ABC_E9455 Neighboring gene cytochrome b561 family, member A3 Neighboring gene STARR-positive B cell enhancer ABC_E5687 Neighboring gene triokinase, FMN cyclase Neighboring gene damage specific DNA binding protein 1 Neighboring gene RIKEN cDNA 4930524O05 gene Neighboring gene von Willebrand factor C and EGF domains

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC129472

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 138

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302218.1 → NP_001289147.1  transmembrane protein 138 isoform 2

    See identical proteins and their annotated locations for NP_001289147.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a downstream alternate 5'-terminal exon and includes an upstream alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC125093, AK007197
    UniProtKB/Swiss-Prot
    Q9D6G5
    Related
    ENSMUST00000236958.2
    Conserved Domains (1) summary
    pfam14935
    Location:38 → 100
    TMEM138; Transmembrane protein 138

  2. NM_028411.4 → NP_082687.1  transmembrane protein 138 isoform 1

    See identical proteins and their annotated locations for NP_082687.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA030680, AC125093, AK031921, AK050471
    Consensus CDS
    CCDS29581.1
    UniProtKB/Swiss-Prot
    Q9D6G5, Q9D9A8
    Related
    ENSMUSP00000025568.3, ENSMUST00000025568.3
    Conserved Domains (1) summary
    pfam14935
    Location:38 → 156
    TMEM138; Transmembrane protein 138

RNA

  1. NR_126092.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the central region, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AA030680, AC125093, AK031921, AK050471
    Related
    ENSMUST00000235990.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    10547842..10554765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247366.3 → XP_011245668.1  transmembrane protein 138 isoform X1

    See identical proteins and their annotated locations for XP_011245668.1

    UniProtKB/Swiss-Prot
    Q9D6G5, Q9D9A8
    Related
    ENSMUSP00000157715.2, ENSMUST00000236099.2
    Conserved Domains (1) summary
    pfam14935
    Location:38 → 156
    TMEM138; Transmembrane protein 138

  2. XM_011247367.3 → XP_011245669.1  transmembrane protein 138 isoform X1

    See identical proteins and their annotated locations for XP_011245669.1

    UniProtKB/Swiss-Prot
    Q9D6G5, Q9D9A8
    Conserved Domains (1) summary
    pfam14935
    Location:38 → 156
    TMEM138; Transmembrane protein 138

  3. XM_036161700.1 → XP_036017593.1  transmembrane protein 138 isoform X2

    Conserved Domains (1) summary
    pfam14935
    Location:38 → 101
    TMEM138; Transmembrane protein 138
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D6G5.1 GenPept UniProtKB/Swiss-Prot:Q9D6G5

Gene LinkOut

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