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Tymp thymidine phosphorylase [ Mus musculus (house mouse) ]

Gene ID: 72962, updated on 5-Mar-2024

Summary

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Official Symbol
Tympprovided by MGI
Official Full Name
thymidine phosphorylaseprovided by MGI
Primary source
MGI:MGI:1920212
See related
Ensembl:ENSMUSG00000022615 AllianceGenome:MGI:1920212
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TP; Ecgf1; PDECGF; Pdgfec; PD-ECGF; 2900072D10Rik
Summary
Enables thymidine phosphorylase activity. Involved in dTMP catabolic process. Predicted to be active in cytosol. Is expressed in alimentary system; axial skeleton; central nervous system; hindlimb; and retina. Used to study mitochondrial DNA depletion syndrome 1. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; mitochondrial DNA depletion syndrome 1; mitochondrial encephalomyopathy; pancreatic cancer; and transitional cell carcinoma. Orthologous to human TYMP (thymidine phosphorylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 180.1), liver adult (RPKM 127.9) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E3; 15 44.86 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89255834..89261282, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89371631..89377036, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39462 Neighboring gene myo-inositol oxygenase Neighboring gene STARR-positive B cell enhancer ABC_E7405 Neighboring gene STARR-positive B cell enhancer ABC_E3152 Neighboring gene lipase maturation factor 2 Neighboring gene non-SMC condensin II complex, subunit H2 Neighboring gene STARR-seq mESC enhancer starr_39464 Neighboring gene SCO2 cytochrome c oxidase assembly protein Neighboring gene ciliary microtubule associated protein 1B Neighboring gene kelch domain containing 7B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Thymidine Phosphorylase Deficiency or Inhibition Preserves Cardiac Function in Mice With Acute Myocardial Infarction. Du L, et al. J Am Heart Assoc, 2023 Apr 4. PMID 36974758, Free PMC Article
  2. Targeting Thymidine Phosphorylase With Tipiracil Hydrochloride Attenuates Thrombosis Without Increasing Risk of Bleeding in Mice. Belcher A, et al. Arterioscler Thromb Vasc Biol, 2021 Feb. PMID 33297751, Free PMC Article
  3. Thymidine phosphorylase promotes angiogenesis and tumour growth in intrahepatic cholangiocarcinoma. Li S, et al. Cell Biochem Funct, 2020 Aug. PMID 32476180
  4. Thymidine Catabolism as a Metabolic Strategy for Cancer Survival. Tabata S, et al. Cell Rep, 2017 May 16. PMID 28514652
  5. Astrocytic TYMP and VEGFA drive blood-brain barrier opening in inflammatory central nervous system lesions. Chapouly C, et al. Brain, 2015 Jun. PMID 25805644, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thymidine phosphorylase promotes angiogenesis and tumour growth in intrahepatic cholangiocarcinoma.
    Title: Thymidine phosphorylase promotes angiogenesis and tumour growth in intrahepatic cholangiocarcinoma.
  2. data identify TYMP as an astrocyte-derived permeability factor, and suggest TYMP and VEGFA together promote blood-brain barrier breakdown.
    Title: Astrocytic TYMP and VEGFA drive blood-brain barrier opening in inflammatory central nervous system lesions.
  3. TYMP participates in multiple platelet signaling pathways and regulates platelet activation and thrombosis. Targeting TYMP might be a novel antiplatelet and antithrombosis therapy.
    Title: Thymidine phosphorylase participates in platelet signaling and promotes thrombosis.
  4. Thymidine phosphorylase and UPP1 double knockout mice showed increased thymidine and deoxyuridine in tissues and developed encephalopathy.
    Title: Unbalanced deoxynucleotide pools cause mitochondrial DNA instability in thymidine phosphorylase-deficient mice.
  5. The PyNpase levels in mouse bladder tissue were significantly higher in BBN-treatment bladder cancer groups than in those in the control group
    Title: Tissue levels of pyrimidine nucleoside phosphorylase activity in human and rodent bladder cancer and normal bladder tissue.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1,4-alpha-oligoglucan phosphorylase activity TAS
Traceable Author Statement
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables pentosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables pyrimidine-nucleoside phosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
enables thymidine phosphorylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables thymidine phosphorylase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within chemotaxis TAS
Traceable Author Statement
more info
 PubMed 
involved_in dTMP catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial genome maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in pyrimidine nucleobase metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleoside metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gastric motility ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of myelination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transmission of nerve impulse ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
thymidine phosphorylase
Names
endothelial cell growth factor 1 (platelet-derived)
gliostatin
platelet derived growth factor, endothelial cell
tdRPase
NP_612175.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138302.3 → NP_612175.1  thymidine phosphorylase

    See identical proteins and their annotated locations for NP_612175.1

    Status: VALIDATED

    Source sequence(s)
    AC113976
    Consensus CDS
    CCDS27747.1
    UniProtKB/Swiss-Prot
    Q99N42
    Related
    ENSMUSP00000023285.5, ENSMUST00000023285.5
    Conserved Domains (4) summary
    PRK05820
    Location:23 → 456
    deoA; thymidine phosphorylase; Reviewed
    smart00941
    Location:374 → 448
    PYNP_C; Pyrimidine nucleoside phosphorylase C-terminal domain
    pfam00591
    Location:96 → 326
    Glycos_transf_3; Glycosyl transferase family, a/b domain
    pfam02885
    Location:24 → 84
    Glycos_trans_3N; Glycosyl transferase family, helical bundle domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    89255834..89261282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_028405.1: Suppressed sequence

    Description
    NM_028405.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99N42.1 GenPept UniProtKB/Swiss-Prot:Q99N42

Gene LinkOut

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