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Top1mt DNA topoisomerase 1, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 72960, updated on 11-Apr-2024

Summary

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Official Symbol
Top1mtprovided by MGI
Official Full Name
DNA topoisomerase 1, mitochondrialprovided by MGI
Primary source
MGI:MGI:1920210
See related
Ensembl:ENSMUSG00000000934 AllianceGenome:MGI:1920210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2900052H09Rik
Summary
Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity. Predicted to be involved in DNA replication and DNA topological change. Located in mitochondrion. Orthologous to human TOP1MT (DNA topoisomerase I mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 9.5), placenta adult (RPKM 8.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Top1mt in Genome Data Viewer
Location:
15 D3; 15 34.69 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75528878..75551184, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75657033..75678800, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39016 Neighboring gene RIKEN cDNA 2810039B14 gene Neighboring gene predicted gene, 38506 Neighboring gene VISTA enhancer mm1304 Neighboring gene STARR-positive B cell enhancer ABC_E4136 Neighboring gene rhophilin, Rho GTPase binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10864 Neighboring gene MAF bZIP transcription factor A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcription profiling suggests that mitochondrial topoisomerase IB acts as a topological barrier and regulator of mitochondrial DNA transcription. Dalla Rosa I, et al. J Biol Chem, 2017 Dec 8. PMID 29021209, Free PMC Article
  2. Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases IIα and IIβ in vertebrate mitochondria. Zhang H, et al. Nucleic Acids Res, 2014 Jun. PMID 24803675, Free PMC Article
  3. Negative regulation of mitochondrial transcription by mitochondrial topoisomerase I. Sobek S, et al. Nucleic Acids Res, 2013 Nov. PMID 23982517, Free PMC Article
  4. The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis. Baechler SA, et al. Nat Commun, 2019 Jan 8. PMID 30622257, Free PMC Article
  5. Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration. Khiati S, et al. Proc Natl Acad Sci U S A, 2015 Sep 8. PMID 26305952, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT.
    Title: Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT.
  2. Study demonstrated that lack of TOP1MT results in delayed and decreased tumor growth due to impaired mitochondrial translation. The TOP1MT genomic signature profile, based on mouse model for Top1mt-KO liver cancers, is correlated with enhanced survival of hepatocellular carcinoma patients.
    Title: The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis.
  3. TOP1MT acts as a topological barrier and regulator for mtDNA transcription and D-loop formation
    Title: Transcription profiling suggests that mitochondrial topoisomerase IB acts as a topological barrier and regulator of mitochondrial DNA transcription.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA topoisomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA topological change IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial nucleoid IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA topoisomerase I, mitochondrial
Names
mitochondrial topoisomerase I
NP_001342518.1
NP_082680.1
XP_036015505.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355589.1 → NP_001342518.1  DNA topoisomerase I, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116393
    UniProtKB/TrEMBL
    B7ZNM9
    Conserved Domains (2) summary
    smart00435
    Location:188 → 564
    TOPEUc; DNA Topoisomerase I (eukaryota)
    pfam02919
    Location:44 → 257
    Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment

  2. NM_028404.3 → NP_082680.1  DNA topoisomerase I, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_082680.1

    Status: VALIDATED

    Source sequence(s)
    AC116393
    Consensus CDS
    CCDS27547.1
    UniProtKB/Swiss-Prot
    Q8R4U6
    Related
    ENSMUSP00000000958.9, ENSMUST00000000958.9
    Conserved Domains (4) summary
    smart00435
    Location:189 → 565
    TOPEUc; DNA Topoisomerase I (eukaryota)
    pfam01028
    Location:261 → 464
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam02919
    Location:44 → 258
    Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment
    pfam14370
    Location:523 → 591
    Topo_C_assoc; C-terminal topoisomerase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    75528878..75551184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159612.1 → XP_036015505.1  DNA topoisomerase I, mitochondrial isoform X1

    Conserved Domains (2) summary
    smart00435
    Location:98 → 474
    TOPEUc; DNA Topoisomerase I (eukaryota)
    pfam02919
    Location:1 → 167
    Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4U6.1 GenPept UniProtKB/Swiss-Prot:Q8R4U6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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