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Phykpl 5-phosphohydroxy-L-lysine phospholyase [ Mus musculus (house mouse) ]

Gene ID: 72947, updated on 21-Apr-2024

Summary

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Official Symbol
Phykplprovided by MGI
Official Full Name
5-phosphohydroxy-L-lysine phospholyaseprovided by MGI
Primary source
MGI:MGI:1920197
See related
Ensembl:ENSMUSG00000020359 AllianceGenome:MGI:1920197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Agxt2l2; 2900006B13Rik
Summary
This gene overlaps in a tail-to-tail orientation the gene encoding heterogeneous nuclear ribonucleoprotein A/B. The terminal exon of this gene is interspersed with exons of heterogeneous nuclear ribonucleoprotein A/B. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 13.7), limb E14.5 (RPKM 13.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 31.08 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51474751..51494091)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51584654..51603264)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Myb/SANT DNA binding domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E5223 Neighboring gene Myb/SANT DNA binding domain containing 5 like Neighboring gene CDC like kinase 4 Neighboring gene collagen, type XXIII, alpha 1 Neighboring gene STARR-positive B cell enhancer mm9_chr11:51347850-51348150 Neighboring gene STARR-positive B cell enhancer ABC_E6980 Neighboring gene STARR-seq mESC enhancer starr_29416 Neighboring gene STARR-positive B cell enhancer ABC_E3947 Neighboring gene STARR-positive B cell enhancer ABC_E255 Neighboring gene heterogeneous nuclear ribonucleoprotein A/B Neighboring gene STARR-positive B cell enhancer ABC_E8400 Neighboring gene STARR-seq mESC enhancer starr_29422 Neighboring gene STARR-positive B cell enhancer ABC_E3948 Neighboring gene required for meiotic nuclear division 5 homolog B Neighboring gene NHP2 ribonucleoprotein Neighboring gene NEDD4 binding protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice. Delprato A, et al. Genes Brain Behav, 2015 Nov. PMID 26449520, Free PMC Article
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
5-phosphohydroxy-L-lysine phospho-lyase
Names
alanine--glyoxylate aminotransferase 2-like 2
NP_001369750.1
NP_082674.1
XP_006534386.1
XP_006534387.1
XP_006534388.1
XP_036012913.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382821.1 → NP_001369750.1  5-phosphohydroxy-L-lysine phospho-lyase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK160557, AL645602, AL662843
    Related
    ENSMUSP00000020625.7, ENSMUST00000020625.7
    Conserved Domains (1) summary
    PRK06148
    Location:1 → 433
    PRK06148; hypothetical protein; Provisional

  2. NM_028398.3 → NP_082674.1  5-phosphohydroxy-L-lysine phospho-lyase isoform 2

    See identical proteins and their annotated locations for NP_082674.1

    Status: VALIDATED

    Source sequence(s)
    AL645602, AL662843
    Consensus CDS
    CCDS24653.1
    UniProtKB/Swiss-Prot
    Q3TUU9, Q8BG04, Q8R1K4
    Related
    ENSMUSP00000132190.2, ENSMUST00000167797.8
    Conserved Domains (2) summary
    cd00610
    Location:30 → 433
    OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...
    COG0160
    Location:15 → 435
    GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]

RNA

  1. NR_168564.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL645602, AL662843

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    51474751..51494091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534325.5 → XP_006534388.1  5-phosphohydroxy-L-lysine phospho-lyase isoform X3

    Conserved Domains (1) summary
    PRK06148
    Location:1 → 438
    PRK06148; hypothetical protein; Provisional

  2. XM_036157020.1 → XP_036012913.1  5-phosphohydroxy-L-lysine phospho-lyase isoform X4

    Conserved Domains (1) summary
    PRK06148
    Location:14 → 240
    PRK06148; hypothetical protein; Provisional

  3. XM_006534323.5 → XP_006534386.1  5-phosphohydroxy-L-lysine phospho-lyase isoform X1

    Conserved Domains (1) summary
    PRK06148
    Location:1 → 438
    PRK06148; hypothetical protein; Provisional

  4. XM_006534324.5 → XP_006534387.1  5-phosphohydroxy-L-lysine phospho-lyase isoform X2

    Conserved Domains (1) summary
    PRK06148
    Location:1 → 433
    PRK06148; hypothetical protein; Provisional

RNA

  1. XR_004937049.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1K4.1 GenPept UniProtKB/Swiss-Prot:Q8R1K4

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