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Asphd2 aspartate beta-hydroxylase domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 72898, updated on 5-Mar-2024

Summary

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Official Symbol
Asphd2provided by MGI
Official Full Name
aspartate beta-hydroxylase domain containing 2provided by MGI
Primary source
MGI:MGI:1920148
See related
Ensembl:ENSMUSG00000029348 AllianceGenome:MGI:1920148
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2900006N09Rik; 9230106G13Rik
Summary
Predicted to enable dioxygenase activity and metal ion binding activity. Predicted to be involved in peptidyl-amino acid modification. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human ASPHD2 (aspartate beta-hydroxylase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 17.6), whole brain E14.5 (RPKM 14.5) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 54.7 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (112532220..112543236, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (112384354..112395370, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 121, retrogene 3 Neighboring gene HPS4, biogenesis of lysosomal organelles complex 3 subunit 2 Neighboring gene predicted gene 20636 Neighboring gene seizure related 6 homolog like Neighboring gene coiled-coil domain containing 121, retrogene 2 Neighboring gene STARR-seq mESC enhancer starr_14007 Neighboring gene RIKEN cDNA 1700034G24 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Clone Names

  • MGC54823

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in peptidyl-amino acid modification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aspartate beta-hydroxylase domain-containing protein 2
NP_001343940.1
NP_001343941.1
NP_001343942.1
NP_001343943.1
NP_001343944.1
NP_082662.1
XP_011247874.1
XP_017176607.1
XP_030110699.1
XP_030110700.1
XP_030110701.1
XP_030110702.1
XP_036021431.1
XP_036021433.1
XP_036021434.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357011.1 → NP_001343940.1  aspartate beta-hydroxylase domain-containing protein 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AC123848
    Consensus CDS
    CCDS19542.1
    UniProtKB/Swiss-Prot
    Q80VP9, Q9CUZ2
    Conserved Domains (1) summary
    pfam05118
    Location:166 → 325
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

  2. NM_001357012.1 → NP_001343941.1  aspartate beta-hydroxylase domain-containing protein 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AC123848
    Consensus CDS
    CCDS19542.1
    UniProtKB/Swiss-Prot
    Q80VP9, Q9CUZ2
    Conserved Domains (1) summary
    pfam05118
    Location:166 → 325
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

  3. NM_001357013.1 → NP_001343942.1  aspartate beta-hydroxylase domain-containing protein 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AC123848
    Consensus CDS
    CCDS19542.1
    UniProtKB/Swiss-Prot
    Q80VP9, Q9CUZ2
    Conserved Domains (1) summary
    pfam05118
    Location:166 → 325
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

  4. NM_001357014.1 → NP_001343943.1  aspartate beta-hydroxylase domain-containing protein 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AC123848
    Consensus CDS
    CCDS19542.1
    UniProtKB/Swiss-Prot
    Q80VP9, Q9CUZ2
    Conserved Domains (1) summary
    pfam05118
    Location:166 → 325
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

  5. NM_001357015.1 → NP_001343944.1  aspartate beta-hydroxylase domain-containing protein 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AC123848
    Consensus CDS
    CCDS19542.1
    UniProtKB/Swiss-Prot
    Q80VP9, Q9CUZ2
    Related
    ENSMUSP00000031291.8, ENSMUST00000031291.9
    Conserved Domains (1) summary
    pfam05118
    Location:166 → 325
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

  6. NM_028386.2 → NP_082662.1  aspartate beta-hydroxylase domain-containing protein 2

    See identical proteins and their annotated locations for NP_082662.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All six variants encode the same protein.
    Source sequence(s)
    AC123848
    Consensus CDS
    CCDS19542.1
    UniProtKB/Swiss-Prot
    Q80VP9, Q9CUZ2
    Conserved Domains (1) summary
    pfam05118
    Location:166 → 325
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    112532220..112543236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254840.2 → XP_030110700.1  aspartate beta-hydroxylase domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q80VP9, Q9CUZ2
    Conserved Domains (1) summary
    pfam05118
    Location:166 → 325
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

  2. XM_030254841.1 → XP_030110701.1  aspartate beta-hydroxylase domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q80VP9, Q9CUZ2
    Conserved Domains (1) summary
    pfam05118
    Location:166 → 325
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

  3. XM_036165541.1 → XP_036021434.1  aspartate beta-hydroxylase domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q80VP9, Q9CUZ2
    Conserved Domains (1) summary
    pfam05118
    Location:166 → 325
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

  4. XM_036165540.1 → XP_036021433.1  aspartate beta-hydroxylase domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q80VP9, Q9CUZ2
    Conserved Domains (1) summary
    pfam05118
    Location:166 → 325
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

  5. XM_030254842.2 → XP_030110702.1  aspartate beta-hydroxylase domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q80VP9, Q9CUZ2
    Conserved Domains (1) summary
    pfam05118
    Location:166 → 325
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

  6. XM_036165538.1 → XP_036021431.1  aspartate beta-hydroxylase domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q80VP9, Q9CUZ2
    Conserved Domains (1) summary
    pfam05118
    Location:166 → 325
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

  7. XM_030254839.2 → XP_030110699.1  aspartate beta-hydroxylase domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q80VP9, Q9CUZ2
    Conserved Domains (1) summary
    pfam05118
    Location:166 → 325
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

  8. XM_011249572.4 → XP_011247874.1  aspartate beta-hydroxylase domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011247874.1

    UniProtKB/Swiss-Prot
    Q80VP9, Q9CUZ2
    Conserved Domains (1) summary
    pfam05118
    Location:166 → 325
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

  9. XM_017321118.3 → XP_017176607.1  aspartate beta-hydroxylase domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q80VP9, Q9CUZ2
    Conserved Domains (1) summary
    pfam05118
    Location:166 → 325
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80VP9.1 GenPept UniProtKB/Swiss-Prot:Q80VP9

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