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NPIPB11 nuclear pore complex interacting protein family member B11 [ Homo sapiens (human) ]

Gene ID: 728888, updated on 5-Mar-2024

Summary

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Official Symbol
NPIPB11provided by HGNC
Official Full Name
nuclear pore complex interacting protein family member B11provided by HGNC
Primary source
HGNC:HGNC:37453
See related
Ensembl:ENSG00000254206 AllianceGenome:HGNC:37453
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPIP
Summary
Predicted to act upstream of or within prevention of polyspermy. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 25.8), bone marrow (RPKM 16.9) and 24 other tissues See more
Orthologs
all
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Genomic context

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Location:
16p11.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (29381167..29406711, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (29663351..29688504, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (29392631..29418032, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371159 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:29296048-29296841 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:29296842-29297634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:29297988-29298594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:29298595-29299200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:29324515-29325223 Neighboring gene sorting nexin 29 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:29330917-29331417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:29339867-29340728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:29340729-29341590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10656 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:29393253-29393874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:29393875-29394494 Neighboring gene small nucleolar RNA U13 Neighboring gene SMG1 pseudogene 6 Neighboring gene BOLA2-SMG1P6 readthrough Neighboring gene coronin 1A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The sequence and analysis of duplication-rich human chromosome 16. Martin J, et al. Nature, 2004 Dec 23. PMID 15616553
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear pore complex-interacting protein family member B11
Names
NPIP-like locus
hepatitis B virus pre-pre-S promoter DNA-binding protein
pps22-1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310137.5 → NP_001297066.2  nuclear pore complex-interacting protein family member B11

    Status: VALIDATED

    Source sequence(s)
    AC025279
    Consensus CDS
    CCDS92131.1
    UniProtKB/Swiss-Prot
    E5RHQ5
    Related
    ENSP00000513761.1, ENST00000698511.1
    Conserved Domains (3) summary
    PTZ00449
    Location:1004 → 1161
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam06409
    Location:46 → 303
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:2 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    29381167..29406711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434576.1 → XP_047290532.1  nuclear pore complex-interacting protein family member B11 isoform X1

  2. XM_047434577.1 → XP_047290533.1  nuclear pore complex-interacting protein family member B11 isoform X2

  3. XM_047434578.1 → XP_047290534.1  nuclear pore complex-interacting protein family member B11 isoform X3

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_017852933.1 Reference GRCh38.p14 PATCHES

    Range
    1676765..1702743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    29663351..29688504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E5RHQ5.1 GenPept UniProtKB/Swiss-Prot:E5RHQ5

Gene LinkOut

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Molecular Biology Databases
Research Materials