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Zdhhc4 zinc finger, DHHC domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 72881, updated on 11-Apr-2024

Summary

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Official Symbol
Zdhhc4provided by MGI
Official Full Name
zinc finger, DHHC domain containing 4provided by MGI
Primary source
MGI:MGI:1920131
See related
Ensembl:ENSMUSG00000001844 AllianceGenome:MGI:1920131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DHHC-4; 1810021D01Rik; 2900029I10Rik
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation and protein targeting to membrane. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in early conceptus; inner cell mass; oocyte; and pancreas tip epithelium. Orthologous to human ZDHHC4 (zinc finger DHHC-type palmitoyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 86.6), genital fat pad adult (RPKM 21.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 82.08 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143302244..143315007, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (143316489..143329268, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52794 Neighboring gene integrator complex subunit 15 Neighboring gene RIKEN cDNA 0610040B10 gene Neighboring gene STARR-seq mESC enhancer starr_14790 Neighboring gene STARR-seq mESC enhancer starr_14791 Neighboring gene glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1 Neighboring gene predicted gene, 38736

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane. Wang J, et al. Cell Rep, 2019 Jan 2. PMID 30605677
  2. Pancreatic islet and progenitor cell surface markers with cell sorting potential. Hald J, et al. Diabetologia, 2012 Jan. PMID 21947380
  3. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
  4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC4
Names
probable palmitoyltransferase ZDHHC4
zinc finger DHHC domain-containing protein 4
NP_001346374.1
NP_082655.1
XP_006504796.1
XP_006504797.1
XP_006504798.1
XP_006504799.1
XP_030110694.1
XP_030110695.1
XP_030110696.1
XP_030110698.1
XP_036021428.1
XP_036021429.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359445.1 → NP_001346374.1  palmitoyltransferase ZDHHC4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC123686
    Conserved Domains (1) summary
    pfam01529
    Location:8 → 149
    DHHC; DHHC palmitoyltransferase

  2. NM_028379.5 → NP_082655.1  palmitoyltransferase ZDHHC4 isoform 1

    See identical proteins and their annotated locations for NP_082655.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK013609, BB868748, BE853198
    Consensus CDS
    CCDS19840.1
    UniProtKB/Swiss-Prot
    Q8R5E0, Q9D6H5
    Related
    ENSMUSP00000001900.3, ENSMUST00000001900.9
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 292
    DHHC; DHHC palmitoyltransferase

RNA

  1. NR_153112.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC123686
    Related
    ENSMUST00000159813.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    143302244..143315007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504735.3 → XP_006504798.1  palmitoyltransferase ZDHHC4 isoform X1

    See identical proteins and their annotated locations for XP_006504798.1

    UniProtKB/Swiss-Prot
    Q8R5E0, Q9D6H5
    Related
    ENSMUSP00000124813.2, ENSMUST00000161915.8
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 292
    DHHC; DHHC palmitoyltransferase

  2. XM_006504733.3 → XP_006504796.1  palmitoyltransferase ZDHHC4 isoform X1

    See identical proteins and their annotated locations for XP_006504796.1

    UniProtKB/Swiss-Prot
    Q8R5E0, Q9D6H5
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 292
    DHHC; DHHC palmitoyltransferase

  3. XM_036165536.1 → XP_036021429.1  palmitoyltransferase ZDHHC4 isoform X1

    UniProtKB/Swiss-Prot
    Q8R5E0, Q9D6H5
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 292
    DHHC; DHHC palmitoyltransferase

  4. XM_006504734.3 → XP_006504797.1  palmitoyltransferase ZDHHC4 isoform X1

    See identical proteins and their annotated locations for XP_006504797.1

    UniProtKB/Swiss-Prot
    Q8R5E0, Q9D6H5
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 292
    DHHC; DHHC palmitoyltransferase

  5. XM_036165535.1 → XP_036021428.1  palmitoyltransferase ZDHHC4 isoform X1

    UniProtKB/Swiss-Prot
    Q8R5E0, Q9D6H5
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 292
    DHHC; DHHC palmitoyltransferase

  6. XM_006504736.5 → XP_006504799.1  palmitoyltransferase ZDHHC4 isoform X1

    See identical proteins and their annotated locations for XP_006504799.1

    UniProtKB/Swiss-Prot
    Q8R5E0, Q9D6H5
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 292
    DHHC; DHHC palmitoyltransferase

  7. XM_030254834.2 → XP_030110694.1  palmitoyltransferase ZDHHC4 isoform X1

    UniProtKB/Swiss-Prot
    Q8R5E0, Q9D6H5
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 292
    DHHC; DHHC palmitoyltransferase

  8. XM_030254835.2 → XP_030110695.1  palmitoyltransferase ZDHHC4 isoform X1

    UniProtKB/Swiss-Prot
    Q8R5E0, Q9D6H5
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 292
    DHHC; DHHC palmitoyltransferase

  9. XM_030254836.2 → XP_030110696.1  palmitoyltransferase ZDHHC4 isoform X2

    Conserved Domains (1) summary
    pfam01529
    Location:8 → 149
    DHHC; DHHC palmitoyltransferase

  10. XM_030254838.2 → XP_030110698.1  palmitoyltransferase ZDHHC4 isoform X2

    Conserved Domains (1) summary
    pfam01529
    Location:8 → 149
    DHHC; DHHC palmitoyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D6H5.1 GenPept UniProtKB/Swiss-Prot:Q9D6H5

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