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CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 [ Homo sapiens (human) ]

Gene ID: 728763, updated on 7-Apr-2024

Summary

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Official Symbol
CROCC2provided by HGNC
Official Full Name
ciliary rootlet coiled-coil, rootletin family member 2provided by HGNC
Primary source
HGNC:HGNC:51677
See related
Ensembl:ENSG00000226321 AllianceGenome:HGNC:51677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in spleen (RPKM 1.3), lung (RPKM 0.7) and 7 other tissues See more
Orthologs
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Genomic context

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Location:
2q37.3
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (240906336..240993311)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (241405412..241492295)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (241845753..241932728)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241807760-241808260 Neighboring gene alanine--glyoxylate aminotransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241834201-241834836 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241836109-241836744 Neighboring gene mab-21 like 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241841593-241842094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241842095-241842594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241844406-241844906 Neighboring gene uncharacterized LOC112268440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241888541-241889058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241893434-241894005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241894006-241894576 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241897431-241898000 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241901185-241902036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241902037-241902887 Neighboring gene up-regulated in colorectal cancer liver metastasis Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241922772-241923279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241923280-241923786 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12525 Neighboring gene TWIST1 associated long noncoding RNA regulated by androgen receptor Neighboring gene uncharacterized LOC107985787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241949545-241950150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241950151-241950754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241957855-241958355 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241957354-241957854 Neighboring gene sushi, nidogen and EGF like domains 1 Neighboring gene SNED1 antisense RNA 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241973517-241974460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241974461-241975402 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241975403-241976346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17413 Neighboring gene mitochondrial transcription termination factor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12526

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Pinstripe: a suite of programs for integrating transcriptomic and proteomic datasets identifies novel proteins and improves differentiation of protein-coding and non-coding genes. Gascoigne DK, et al. Bioinformatics, 2012 Dec 1. PMID 23044541
  2. Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development. Wang P, et al. J Clin Invest, 2019 Jul 25. PMID 31343991, Free PMC Article
  3. Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma. Mahlokozera T, et al. Nat Commun, 2021 Nov 3. PMID 34732716, Free PMC Article
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ciliary rootlet coiled-coil protein 2
Names
putative ciliary rootlet coiled-coil protein 2
putative ciliary rootlet coiled-coil protein-like 3 protein
rootletin-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351305.2 → NP_001338234.1  ciliary rootlet coiled-coil protein 2

    Status: VALIDATED

    Source sequence(s)
    AC104809, BU682871, BX091140, DT932542, DV080150, DV080240, DV080412, DV080499, DV080638, DY655377, DY655577, DY655578, EG327310, EG327700
    Consensus CDS
    CCDS92994.1
    UniProtKB/Swiss-Prot
    H7BZ55
    UniProtKB/TrEMBL
    A0A8J8ZEH8
    Related
    ENSP00000508848.1, ENST00000690015.1
    Conserved Domains (4) summary
    PTZ00121
    Location:1051 → 1639
    PTZ00121; MAEBL; Provisional
    COG4942
    Location:401 → 606
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:538 → 1293
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15035
    Location:120 → 265
    Rootletin; Ciliary rootlet component, centrosome cohesion

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    240906336..240993311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453115.2 → XP_024308883.1  ciliary rootlet coiled-coil protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8J8ZEH8
    Conserved Domains (4) summary
    pfam15035
    Location:120 → 265
    Rootletin; Ciliary rootlet component, centrosome cohesion
    cl25732
    Location:538 → 1293
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1051 → 1639
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27539
    Location:401 → 606
    Peptidase_M23; Peptidase family M23

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    241405412..241492295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343722.1 → XP_054199697.1  ciliary rootlet coiled-coil protein 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
H7BZ55.4 GenPept UniProtKB/Swiss-Prot:H7BZ55

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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