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EIF3CL eukaryotic translation initiation factor 3 subunit C like [ Homo sapiens (human) ]

Gene ID: 728689, updated on 3-Apr-2024

Summary

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Official Symbol
EIF3CLprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit C likeprovided by HGNC
Primary source
HGNC:HGNC:26347
See related
Ensembl:ENSG00000205609 AllianceGenome:HGNC:26347
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex. The encoded protein is nearly identical to another protein, eIF3c, from a related gene. The eIF3 complex binds the 40S ribosome and mRNAs to enable translation initiation. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in ovary (RPKM 103.1), thyroid (RPKM 97.8) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
16p12.1
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (28379581..28426418, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (28659992..28707115, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28390902..28415206, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene SH3 domain binding kinase 1 Neighboring gene uncharacterized LOC124903670 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:28303338-28303509 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7307 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28341775-28342274 Neighboring gene MPRA-validated peak2550 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28347523-28348022 Neighboring gene nuclear pore complex interacting protein family member B6 Neighboring gene microRNA 6862-1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:28414989-28415489 Neighboring gene cell division cycle 37 pseudogene 2 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:28459200-28460080 Neighboring gene nuclear pore complex interacting protein family member B7 Neighboring gene CLN3 lysosomal/endosomal transmembrane protein, battenin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structural roles for human translation factor eIF3 in initiation of protein synthesis. Siridechadilok B, et al. Science, 2005 Dec 2. PMID 16322461
  2. Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association. Kolupaeva VG, et al. RNA, 2005 Apr. PMID 15703437, Free PMC Article
  3. Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column. Imami K, et al. Anal Sci, 2008 Jan. PMID 18187866
  4. Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry. Molina H, et al. Proc Natl Acad Sci U S A, 2007 Feb 13. PMID 17287340, Free PMC Article
  5. Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies. Morris-Desbois C, et al. J Cell Sci, 1999 Oct. PMID 10504338

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit C-like protein
Names
eIF3 p110
eukaryotic translation initiation factor 3 subunit 8
eukaryotic translation initiation factor 3, subunit 8, 110kDa-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099661.2 → NP_001093131.1  eukaryotic translation initiation factor 3 subunit C-like protein

    See identical proteins and their annotated locations for NP_001093131.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC138894, CA420261, DA645577, DC410988
    Consensus CDS
    CCDS42136.1
    UniProtKB/Swiss-Prot
    B5ME19
    UniProtKB/TrEMBL
    A1KYQ7
    Related
    ENSP00000381917.3, ENST00000398944.7
    Conserved Domains (2) summary
    smart00753
    Location:779 → 867
    PAM; PCI/PINT associated module
    pfam05470
    Location:29 → 706
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

  2. NM_001317856.1 → NP_001304785.1  eukaryotic translation initiation factor 3 subunit C-like protein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC138894, BQ686089, CA420261, DC410988
    Consensus CDS
    CCDS42136.1
    UniProtKB/Swiss-Prot
    B5ME19
    UniProtKB/TrEMBL
    A1KYQ7
    Conserved Domains (2) summary
    smart00753
    Location:779 → 867
    PAM; PCI/PINT associated module
    pfam05470
    Location:29 → 706
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

  3. NM_001317857.2 → NP_001304786.1  eukaryotic translation initiation factor 3 subunit C-like protein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. All three variants encode the same protein.
    Source sequence(s)
    AC138894, DC410988
    Consensus CDS
    CCDS42136.1
    UniProtKB/Swiss-Prot
    B5ME19
    UniProtKB/TrEMBL
    A1KYQ7
    Related
    ENSP00000370258.5, ENST00000380876.5
    Conserved Domains (2) summary
    smart00753
    Location:779 → 867
    PAM; PCI/PINT associated module
    pfam05470
    Location:29 → 706
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    28379581..28426418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434558.1 → XP_047290514.1  eukaryotic translation initiation factor 3 subunit C-like protein isoform X1

    UniProtKB/Swiss-Prot
    B5ME19

  2. XM_017023621.2 → XP_016879110.1  eukaryotic translation initiation factor 3 subunit C-like protein isoform X3

    UniProtKB/TrEMBL
    B3KNZ4
    Conserved Domains (2) summary
    smart00088
    Location:462 → 550
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam05470
    Location:2 → 389
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

  3. XM_017023620.3 → XP_016879109.1  eukaryotic translation initiation factor 3 subunit C-like protein isoform X2

    UniProtKB/TrEMBL
    A1KYQ7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    28659992..28707115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313819.1 → XP_054169794.1  eukaryotic translation initiation factor 3 subunit C-like protein isoform X1

    UniProtKB/Swiss-Prot
    A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98

  2. XM_054313817.1 → XP_054169792.1  eukaryotic translation initiation factor 3 subunit C-like protein isoform X1

    UniProtKB/Swiss-Prot
    A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98

  3. XM_054313818.1 → XP_054169793.1  eukaryotic translation initiation factor 3 subunit C-like protein isoform X1

    UniProtKB/Swiss-Prot
    A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98

  4. XM_054313820.1 → XP_054169795.1  eukaryotic translation initiation factor 3 subunit C-like protein isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B5ME19.1 GenPept UniProtKB/Swiss-Prot:B5ME19

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