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MEIKIN meiotic kinetochore factor [ Homo sapiens (human) ]

Gene ID: 728637, updated on 10-Dec-2024

Summary

Official Symbol
MEIKINprovided by HGNC
Official Full Name
meiotic kinetochore factorprovided by HGNC
Primary source
HGNC:HGNC:51253
See related
Ensembl:ENSG00000239642 MIM:616232; AllianceGenome:HGNC:51253
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPO13
Summary
Predicted to be involved in meiotic chromosome segregation and meiotic sister chromatid cohesion. Predicted to be located in kinetochore. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward testis (RPKM 3.3) See more
Orthologs
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Genomic context

See MEIKIN in Genome Data Viewer
Location:
5q31.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (131806990..131945663, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (132326854..132465546, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (131142683..131281356, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor 6 Neighboring gene Sharpr-MPRA regulatory region 5338 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:130970112-130970694 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:130970824-130972023 Neighboring gene folliculin interacting protein 1 Neighboring gene ACTB pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23059 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16308 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16309 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:131267911-131268464 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:131293433-131293633 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:131329699-131330242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:131330787-131331330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:131337447-131338042 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16310 Neighboring gene uncharacterized LOC124901062 Neighboring gene acyl-CoA synthetase long chain family member 6 Neighboring gene ACSL6 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Potential readthrough

Included gene: ACSL6

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in female meiosis chromosome segregation  
involved_in female meiosis chromosome segregation  
involved_in homologous chromosome segregation  
involved_in homologous chromosome segregation  
involved_in male meiosis chromosome segregation  
involved_in male meiosis chromosome segregation  
involved_in meiotic sister chromatid cohesion involved in meiosis I  
involved_in meiotic sister chromatid cohesion involved in meiosis I  
involved_in meiotic sister chromatid cohesion, centromeric  
involved_in meiotic sister chromatid cohesion, centromeric  
Component Evidence Code Pubs
located_in condensed chromosome, centromeric region  
located_in kinetochore  

General protein information

Preferred Names
meiosis-specific kinetochore protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303622.2NP_001290551.1  meiosis-specific kinetochore protein

    See identical proteins and their annotated locations for NP_001290551.1

    Status: VALIDATED

    Source sequence(s)
    AB987829, BG181951, DB455285
    Consensus CDS
    CCDS75292.2
    UniProtKB/Swiss-Prot
    A0A087WXM9, A0A0A8IBZ9
    UniProtKB/TrEMBL
    A0A0G2JND4
    Related
    ENSP00000488568.1, ENST00000442687.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    131806990..131945663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    132326854..132465546 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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