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C2orf92 chromosome 2 open reading frame 92 [ Homo sapiens (human) ]

Gene ID: 728537, updated on 5-Mar-2024

Summary

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Official Symbol
C2orf92provided by HGNC
Official Full Name
chromosome 2 open reading frame 92provided by HGNC
Primary source
HGNC:HGNC:49272
See related
Ensembl:ENSG00000228486 AllianceGenome:HGNC:49272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LINC01125
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 7.5), skin (RPKM 1.9) and 16 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
2q11.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (97663941..97703066)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (98122162..98161282)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (98286176..98319529)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:98261483-98262417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16239 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:98278969-98279610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11793 Neighboring gene U4 spliceosomal RNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16241 Neighboring gene UBTF like 6 (pseudogene) Neighboring gene cytochrome c oxidase subunit 5B Neighboring gene actin related protein 1B Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:98304422-98305621 Neighboring gene RNA, U4 small nuclear 8, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:98307157-98307956 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98323640-98324200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98324201-98324759 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:98327684-98327873 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:98329847-98330820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98332052-98332567 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98332568-98333082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98340736-98341326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98356023-98356522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11794 Neighboring gene zeta chain of T cell receptor associated protein kinase 70 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16244 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98379903-98380684 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:98386577-98387090 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:98387091-98387603 Neighboring gene uncharacterized LOC124907861 Neighboring gene transmembrane protein 131

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Discovery of a novel linc01125 isoform in serum exosomes as a promising biomarker for NSCLC diagnosis and survival assessment. Xian J, et al. Carcinogenesis, 2021 Jun 21. PMID 33928340
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. m6A Writer METTL3-Mediated lncRNA LINC01125 Prevents the Malignancy of Papillary Thyroid Cancer.
    Title: m6A Writer METTL3-Mediated lncRNA LINC01125 Prevents the Malignancy of Papillary Thyroid Cancer.
  2. Discovery of a novel linc01125 isoform in serum exosomes as a promising biomarker for NSCLC diagnosis and survival assessment.
    Title: Discovery of a novel linc01125 isoform in serum exosomes as a promising biomarker for NSCLC diagnosis and survival assessment.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Clone Names

  • AC017099.3

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein C2orf92
Names
long intergenic non-protein coding RNA 1125

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351368.2 → NP_001338297.1  uncharacterized protein C2orf92 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC017099
    Consensus CDS
    CCDS86862.1
    UniProtKB/Swiss-Prot
    A0A1B0GVN3
    Related
    ENSP00000490587.1, ENST00000627399.4

  2. NM_001410919.1 → NP_001397848.1  uncharacterized protein C2orf92 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC017099
    Consensus CDS
    CCDS92816.1
    UniProtKB/TrEMBL
    A0A1B0GW88
    Related
    ENSP00000490827.1, ENST00000599501.6

RNA

  1. NR_038386.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA448462, AC017099, AI637498, BC039374, DB066031
    Related
    ENST00000451384.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    97663941..97703066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453105.2 → XP_024308873.1  uncharacterized protein C2orf92 isoform X1

  2. XM_024453109.2 → XP_024308877.1  uncharacterized protein C2orf92 isoform X3

  3. XM_024453106.2 → XP_024308874.1  uncharacterized protein C2orf92 isoform X2

  4. XM_024453113.2 → XP_024308881.1  uncharacterized protein C2orf92 isoform X7

  5. XM_024453110.2 → XP_024308878.1  uncharacterized protein C2orf92 isoform X4

  6. XM_024453111.2 → XP_024308879.1  uncharacterized protein C2orf92 isoform X5

  7. XM_047445723.1 → XP_047301679.1  uncharacterized protein C2orf92 isoform X6

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791765.1 Reference GRCh38.p14 PATCHES

    Range
    589972..629097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332989.1 → XP_054188964.1  uncharacterized protein C2orf92 isoform X1

  2. XM_054332991.1 → XP_054188966.1  uncharacterized protein C2orf92 isoform X3

  3. XM_054332990.1 → XP_054188965.1  uncharacterized protein C2orf92 isoform X2

  4. XM_054332995.1 → XP_054188970.1  uncharacterized protein C2orf92 isoform X7

  5. XM_054332992.1 → XP_054188967.1  uncharacterized protein C2orf92 isoform X4

  6. XM_054332993.1 → XP_054188968.1  uncharacterized protein C2orf92 isoform X5

  7. XM_054332994.1 → XP_054188969.1  uncharacterized protein C2orf92 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    98122162..98161282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343707.1 → XP_054199682.1  uncharacterized protein C2orf92 isoform X1

  2. XM_054343709.1 → XP_054199684.1  uncharacterized protein C2orf92 isoform X3

  3. XM_054343708.1 → XP_054199683.1  uncharacterized protein C2orf92 isoform X2

  4. XM_054343713.1 → XP_054199688.1  uncharacterized protein C2orf92 isoform X7

  5. XM_054343710.1 → XP_054199685.1  uncharacterized protein C2orf92 isoform X4

  6. XM_054343711.1 → XP_054199686.1  uncharacterized protein C2orf92 isoform X5

  7. XM_054343712.1 → XP_054199687.1  uncharacterized protein C2orf92 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A1B0GVN3.1 GenPept UniProtKB/Swiss-Prot:A0A1B0GVN3

Gene LinkOut

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