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SPDYE8 speedy/RINGO cell cycle regulator family member E8 [ Homo sapiens (human) ]

Gene ID: 728524, updated on 23-Nov-2023

Summary

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Official Symbol
SPDYE8provided by HGNC
Official Full Name
speedy/RINGO cell cycle regulator family member E8provided by HGNC
Primary source
HGNC:HGNC:33771
See related
Ensembl:ENSG00000273520 AllianceGenome:HGNC:33771
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPDYE9; SPDYE8P
Expression
Broad expression in testis (RPKM 7.7), skin (RPKM 2.0) and 23 other tissues See more
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Genomic context

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See SPDYE8 in Genome Data Viewer
Location:
7q11.23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (73019719..73029766, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (74247948..74258006, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (72490248..72500313, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901672 Neighboring gene STAG3 cohesin complex component like 3 (pseudogene) Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:72475839-72476347 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:72476348-72476856 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 7 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 8 Neighboring gene speedy/RINGO cell cycle regulator family member E11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Toward a complete human genome sequence. Sanger Center, et al. Genome Res, 1998 Nov. PMID 9847074
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Clone Names

  • MGC48646, MGC131642

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative speedy protein E8
Names
Williams Beuren syndrome chromosome region 19 pseudogene
speedy homolog E pseudogene
speedy homolog E8, pseudogene
speedy/RINGO cell cycle regulator family member E1 pseudogene
speedy/RINGO cell cycle regulator family member E8, pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382525.2 → NP_001369454.1  putative speedy protein E8

    Status: VALIDATED

    Source sequence(s)
    AC211476
    Consensus CDS
    CCDS94114.1
    UniProtKB/Swiss-Prot
    A0A494C191, P0DTA3, P0DUD1, P0DUD2, P0DUX0
    Related
    ENSP00000498819.1, ENST00000333385.11
    Conserved Domains (1) summary
    pfam11357
    Location:107 → 261
    Spy1; Cell cycle regulatory protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    73019719..73029766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    74247948..74258006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_006254.1: Suppressed sequence

    Description
    NG_006254.1: This RefSeq was permanently suppressed because it is now thought that this gene is a transcribed pseudogene.

  2. NM_001023562.1: Suppressed sequence

    Description
    NM_001023562.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.

  3. NM_001032389.2: Suppressed sequence

    Description
    NM_001032389.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.

  4. NR_003664.2: Suppressed sequence

    Description
    NR_003664.2: This RefSeq was removed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DUD1.1 GenPept UniProtKB/Swiss-Prot:P0DUD1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials