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Mblac2 metallo-beta-lactamase domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 72852, updated on 11-Apr-2024

Summary

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Official Symbol
Mblac2provided by MGI
Official Full Name
metallo-beta-lactamase domain containing 2provided by MGI
Primary source
MGI:MGI:1920102
See related
Ensembl:ENSMUSG00000051098 AllianceGenome:MGI:1920102
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2900024O10Rik
Summary
Predicted to enable palmitoyl-CoA hydrolase activity. Predicted to be located in endoplasmic reticulum membrane and plasma membrane. Is expressed in cerebral cortex ventricular layer. Orthologous to human MBLAC2 (metallo-beta-lactamase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 8.8), frontal lobe adult (RPKM 6.0) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Mblac2 in Genome Data Viewer
Location:
13 C3; 13 43.68 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (81859536..81901394)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (81711417..81753275)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene LysM, putative peptidoglycan-binding, domain containing 3 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide G Neighboring gene STARR-seq mESC enhancer starr_35131 Neighboring gene STARR-positive B cell enhancer ABC_E11550 Neighboring gene STARR-seq mESC enhancer starr_35132 Neighboring gene STARR-positive B cell enhancer ABC_E604 Neighboring gene STARR-positive B cell enhancer ABC_E3088 Neighboring gene centrin 3 Neighboring gene STARR-positive B cell enhancer ABC_E7258 Neighboring gene STARR-seq mESC enhancer starr_35135 Neighboring gene STARR-seq mESC enhancer starr_35136 Neighboring gene predicted gene, 32836

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
  2. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-lactamase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acyl-coenzyme A thioesterase MBLAC2
Names
acyl-CoA thioesterase MBLAC2
beta-lactamase MBLAC2
metallo-beta-lactamase domain-containing protein 2
palmitoyl-coenzyme A thioesterase MBLAC2
NP_082648.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028372.1 → NP_082648.1  acyl-coenzyme A thioesterase MBLAC2

    See identical proteins and their annotated locations for NP_082648.1

    Status: PROVISIONAL

    Source sequence(s)
    AK046032, BU559276, CAAA01027445
    Consensus CDS
    CCDS26662.1
    UniProtKB/Swiss-Prot
    G3X997, Q8BL86
    Related
    ENSMUSP00000051644.6, ENSMUST00000057598.7
    Conserved Domains (1) summary
    cd07712
    Location:22 → 231
    MBLAC2-like_MBL-fold; uncharacterized human metallo-beta-lactamase domain-containing protein 2 and related proteins; MBL-fold metallo hydrolase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    81859536..81901394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BL86.2 GenPept UniProtKB/Swiss-Prot:Q8BL86

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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