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Kctd17 potassium channel tetramerisation domain containing 17 [ Mus musculus (house mouse) ]

Gene ID: 72844, updated on 11-Apr-2024

Summary

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Official Symbol
Kctd17provided by MGI
Official Full Name
potassium channel tetramerisation domain containing 17provided by MGI
Primary source
MGI:MGI:1920094
See related
Ensembl:ENSMUSG00000033287 AllianceGenome:MGI:1920094
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2900008M13Rik
Summary
Predicted to enable cullin family protein binding activity and identical protein binding activity. Predicted to be involved in endoplasmic reticulum calcium ion homeostasis; positive regulation of cilium assembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in myoclonic dystonia 26. Orthologous to human KCTD17 (potassium channel tetramerization domain containing 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 65.0), adrenal adult (RPKM 57.3) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E1; 15 37.49 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78312578..78323503)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78428564..78439303)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52185 Neighboring gene mercaptopyruvate sulfurtransferase Neighboring gene predicted gene, 36644 Neighboring gene predicted gene, 41355 Neighboring gene transmembrane serine protease 6 Neighboring gene STARR-positive B cell enhancer ABC_E8598 Neighboring gene STARR-seq mESC enhancer starr_39146 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:78306098-78306207 Neighboring gene interleukin 2 receptor, beta chain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hepatocyte Kctd17 Inhibition Ameliorates Glucose Intolerance and Hepatic Steatosis Caused by Obesity-induced Chrebp Stabilization. Oh AR, et al. Gastroenterology, 2023 Mar. PMID 36402191, Free PMC Article
  2. Kctd17-mediated Chop degradation promotes adipogenic differentiation. Shin MC, et al. Biochem Biophys Res Commun, 2023 Apr 23. PMID 36868076
  3. Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis. Kim K, et al. Gastroenterology, 2017 Dec. PMID 28859855, Free PMC Article
  4. Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Otto T, et al. Proc Natl Acad Sci U S A, 2017 Oct 3. PMID 28923932, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kctd17-mediated Chop degradation promotes adipogenic differentiation.
    Title: Kctd17-mediated Chop degradation promotes adipogenic differentiation.
  2. Hepatocyte Kctd17 Inhibition Ameliorates Glucose Intolerance and Hepatic Steatosis Caused by Obesity-induced Chrebp Stabilization.
    Title: Hepatocyte Kctd17 Inhibition Ameliorates Glucose Intolerance and Hepatic Steatosis Caused by Obesity-induced Chrebp Stabilization.
  3. KCTD17, which is up-regulated in liver tissues of obese mice and patients with NAFLD, binds to phosphorylated PHLPP2 to target it for ubiquitin-mediated degradation; this increases expression of genes that regulate lipogenesis to promote hepatic steatosis.
    Title: Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BTB/POZ domain-containing protein KCTD17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289671.2 → NP_001276600.2  BTB/POZ domain-containing protein KCTD17 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL590144
    Consensus CDS
    CCDS79384.1
    UniProtKB/TrEMBL
    E0CYD2
    Related
    ENSMUSP00000124290.3, ENSMUST00000162517.9
    Conserved Domains (1) summary
    cd18391
    Location:24 → 124
    BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

  2. NM_001289672.2 → NP_001276601.2  BTB/POZ domain-containing protein KCTD17 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL590144
    Consensus CDS
    CCDS79385.1
    UniProtKB/TrEMBL
    A6H697, F6SYN4
    Related
    ENSMUSP00000133210.4, ENSMUST00000166142.11
    Conserved Domains (1) summary
    cd18391
    Location:24 → 124
    BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

  3. NM_001289673.2 → NP_001276602.2  BTB/POZ domain-containing protein KCTD17 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exons in the 3' coding region which results in a frameshift compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL590144
    UniProtKB/TrEMBL
    E0CZ97
    Related
    ENSMUSP00000125574.2, ENSMUST00000159771.8
    Conserved Domains (1) summary
    cd18391
    Location:24 → 124
    BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

RNA

  1. NR_110357.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two exons and uses an alternate penultimate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL590144

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    78312578..78323503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521460.5 → XP_006521523.3  BTB/POZ domain-containing protein KCTD17 isoform X1

    Conserved Domains (1) summary
    cd18391
    Location:103 → 203
    BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

  2. XM_036159611.1 → XP_036015504.1  BTB/POZ domain-containing protein KCTD17 isoform X2

    Conserved Domains (1) summary
    cd18391
    Location:103 → 203
    BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

  3. XM_006521461.5 → XP_006521524.3  BTB/POZ domain-containing protein KCTD17 isoform X3

    Conserved Domains (1) summary
    cd18391
    Location:103 → 203
    BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

  4. XM_030248792.2 → XP_030104652.2  BTB/POZ domain-containing protein KCTD17 isoform X4

    Conserved Domains (1) summary
    cd18391
    Location:103 → 203
    BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

RNA

  1. XR_004938873.1 RNA Sequence

  2. XR_004938874.1 RNA Sequence

  3. XR_001781569.3 RNA Sequence

  4. XR_001781568.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081367.1: Suppressed sequence

    Description
    NM_001081367.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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