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TSPY4 testis specific protein Y-linked 4 [ Homo sapiens (human) ]

Gene ID: 728395, updated on 3-Apr-2024

Summary

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Official Symbol
TSPY4provided by HGNC
Official Full Name
testis specific protein Y-linked 4provided by HGNC
Primary source
HGNC:HGNC:37287
See related
Ensembl:ENSG00000233803 AllianceGenome:HGNC:37287
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSPY8; TSPY10
Summary
Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in several processes, including gonadal mesoderm development; nucleosome assembly; and spermatogenesis. Predicted to be active in chromatin and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 40.8) See more
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Genomic context

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Location:
Yp11.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (9337464..9340278)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (9024834..9027648)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (9175073..9177887)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein Y-linked family 1 member A3, pseudogene Neighboring gene RNA binding motif protein Y-linked family 1 member G, pseudogene Neighboring gene testis expressed transcript, Y-linked 20 Neighboring gene family with sequence similarity 197 Y-linked member 8 Neighboring gene testis specific protein Y-linked 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Clone Names

  • FLJ36094

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in gonadal mesoderm development IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
testis-specific Y-encoded protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164471.2 → NP_001157943.1  testis-specific Y-encoded protein 4

    See identical proteins and their annotated locations for NP_001157943.1

    Status: VALIDATED

    Source sequence(s)
    AC006158
    Consensus CDS
    CCDS48202.1
    UniProtKB/Swiss-Prot
    P0CV99
    UniProtKB/TrEMBL
    Q540R4
    Related
    ENSP00000399668.2, ENST00000426950.6
    Conserved Domains (1) summary
    cl08298
    Location:132 → 294
    NAP; Nucleosome assembly protein (NAP)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

    Range
    9337464..9340278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272743.5 → XP_005272800.1  testis-specific Y-encoded protein 4 isoform X1

    UniProtKB/TrEMBL
    A6NEC3, Q540R4
    Related
    ENSP00000372471.1, ENST00000383008.1
    Conserved Domains (1) summary
    cl08298
    Location:109 → 279
    NAP; Nucleosome assembly protein (NAP)

  2. XM_017030065.2 → XP_016885554.1  testis-specific Y-encoded protein 4 isoform X2

RNA

  1. XR_001756006.2 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791821.1 Reference GRCh38.p14 PATCHES

    Range
    204746..207560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333420.1 → XP_054189395.1  testis-specific Y-encoded protein 4 isoform X1

    UniProtKB/TrEMBL
    A6NEC3

  2. XM_054333421.1 → XP_054189396.1  testis-specific Y-encoded protein 4 isoform X2

RNA

  1. XR_008485840.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060948.1 Alternate T2T-CHM13v2.0

    Range
    9024834..9027648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328329.1 → XP_054184304.1  testis-specific Y-encoded protein 4 isoform X3

    UniProtKB/TrEMBL
    A6NEC3

  2. XM_054328330.1 → XP_054184305.1  testis-specific Y-encoded protein 4 isoform X4

RNA

  1. XR_008485526.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CV99.1 GenPept UniProtKB/Swiss-Prot:P0CV99

Gene LinkOut

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