Pard3b par-3 family cell polarity regulator beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pard3bprovided by MGI
Official Full Name: par-3 family cell polarity regulator betaprovided by MGI
Primary source: MGI:MGI:1919301
See related: Ensembl:ENSMUSG00000052062 AllianceGenome:MGI:1919301
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PAR3B; PAR3L; Als2cr19; PAR3beta; 1810008K04Rik; 2010002N16Rik; 2810455B10Rik
Summary: Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including establishment of cell polarity; establishment of centrosome localization; and establishment or maintenance of epithelial cell apical/basal polarity. Predicted to act upstream of or within cell division. Predicted to be located in cell junction. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including adherens junction; apical junction complex; and apical plasma membrane. Is expressed in brain; genitourinary system; nose; and stomach. Orthologous to human PARD3B (par-3 family cell polarity regulator beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 4.0), colon adult (RPKM 2.1) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C2; 1 30.92 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (61677825..62681443)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (61638667..62642284)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Par3L is expressed by multipotent stem cells in the terminal end buds of murine mammary glands. Ablation of Par3L resulted in rapid and profound stem cell loss.
Title: The Par3-like polarity protein Par3L is essential for mammary stem cell maintenance.
Atp6ap2/(P)RR interacted with partitioning defective 3 homolog (PAR3) protein, which is known to function in the Par-atypical protein kinase C
Title: Atp6ap2/(pro)renin receptor interacts with Par3 as a cell polarity determinant required for laminar formation during retinal development in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125372 (e-PCR)
- UniSTS:162194

D1Mit326 (e-PCR), detects polymorphism
- UniSTS:128684

MARC_21133-21134:1025201105:1 (e-PCR)
- UniSTS:268488

fk56e12.x1 (e-PCR)
- UniSTS:201209

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of centrosome localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in apical junction complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: partitioning defective 3 homolog B

Names: PAR3-L protein; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein homolog; par-3 partitioning defective 3 homolog B; partitioning defective 3-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081050.3 → NP_001074519.2 partitioning defective 3 homolog B

See identical proteins and their annotated locations for NP_001074519.2

Status: VALIDATED

Source sequence(s)

AC101661, AL645544, AL645727, AL662815, AL662920

Consensus CDS

CCDS48276.1

UniProtKB/Swiss-Prot

Q5SV53, Q9CSB4

UniProtKB/TrEMBL

Q5SV55

Related

ENSMUSP00000074837.4, ENSMUST00000075374.10

Conserved Domains (3) summary

smart00228
Location:380 → 469

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:501 → 589

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:1 → 143

DUF3534; Domain of unknown function (DUF3534)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

61677825..62681443

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153731.1 → XP_036009624.1 partitioning defective 3 homolog B isoform X4

Conserved Domains (3) summary

smart00228
Location:415 → 504

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:536 → 624

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:2 → 74

DUF3534; N-terminal of Par3 and HAL proteins
XM_011238602.4 → XP_011236904.1 partitioning defective 3 homolog B isoform X3

Conserved Domains (3) summary

smart00228
Location:415 → 504

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:536 → 624

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:2 → 74

DUF3534; N-terminal of Par3 and HAL proteins
XM_006496298.4 → XP_006496361.1 partitioning defective 3 homolog B isoform X1

UniProtKB/TrEMBL

Q5SV55

Conserved Domains (3) summary

smart00228
Location:415 → 504

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:536 → 624

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:2 → 74

DUF3534; N-terminal of Par3 and HAL proteins
XM_006496299.5 → XP_006496362.1 partitioning defective 3 homolog B isoform X2

UniProtKB/TrEMBL

Q5SV55

Conserved Domains (2) summary

smart00228
Location:201 → 290

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:322 → 410

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...