MAFIP MAFF interacting protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAFIPprovided by HGNC
Official Full Name: MAFF interacting proteinprovided by HGNC
Primary source: HGNC:HGNC:31102
Gene type: pseudo
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIP; pp5644; TEKT4P4
Summary: This gene was originally thought to be a protein coding gene. However, the encoded protein sequence is highly similar to the C-terminal sequence of the tektin-4 protein, and the transcript sequences of this gene are highly similar to the TEKT4 pseudogenes, which are found on chromosomes 4, 21 and Y, respectively. Therefore, this gene is thought to be another pseudogene of the TEKT4 gene (GeneID:150483). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2012]
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Genomic context

Location:: chromosome: 14

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	14 Unlocalized Scaffold	NT_113888.1 (53589..115073, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (2929065..2991090, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	4 Unlocalized Scaffold	NT_113888.1 (53589..115073, complement)

NT_113888.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAFIP overexpression inhibited activation of the NF-kappaB pathway by preventing the phosphorylation of IKK & IkappaBalpha, degradation of IkappaBalpha & p65 nuclear localization. Knockdown of MAFIP activated the NF-kappaB pathway & promoted cell proliferation.
Title: MAFIP is a tumor suppressor in cervical cancer that inhibits activation of the nuclear factor-kappa B pathway.
results indicated that MIP interacted with NEMO and suggested that MIP could be involved in NF-kappaB signaling pathway
Title: Finding a novel interacting protein of the hepatic carcinoma related gene MIP: NF-κB essential modulator (NEMO).

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G43582 (e-PCR)
- UniSTS:95028

SHGC-147299 (e-PCR)
- UniSTS:184913

D17S837 (e-PCR)
- UniSTS:473276

G27368 (e-PCR)
- UniSTS:48857

Other Names

MAFF interacting protein (pseudogene)
tektin 4 pseudogene 4
tektin-4 like protein PP5644

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in cilium movement involved in cell motility	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

NR_046439.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript.

Source sequence(s)

AC145212, AF289559, AK096952, CK004054
NR_046440.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks several internal exons compared to variant 1.

Source sequence(s)

AC145212, AF289559, CK004054, DQ786282
NR_046441.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks several internal exons and has a different 3' structure compared to variant 1.

Source sequence(s)

AC145212, AF289559, CK004054
NR_046442.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks several 3' exons and has an alternate 3' terminal exon compared to variant 1.

Source sequence(s)

AC145212, CA419667, CK004054, DA007572

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NT_113888.1 Reference GRCh38.p14 Primary Assembly

Range

53589..115073 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060938.1 Alternate T2T-CHM13v2.0

Range

2929065..2991090 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001190825.1: Suppressed sequence

Description

NM_001190825.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.