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ROCK1P1 Rho associated coiled-coil containing protein kinase 1 pseudogene 1 [ Homo sapiens (human) ]

Gene ID: 727758, updated on 10-Oct-2023

Summary

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Official Symbol
ROCK1P1provided by HGNC
Official Full Name
Rho associated coiled-coil containing protein kinase 1 pseudogene 1provided by HGNC
Primary source
HGNC:HGNC:37832
See related
Ensembl:ENSG00000290877 AllianceGenome:HGNC:37832
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ROCK1P
Expression
Ubiquitous expression in testis (RPKM 12.3), bone marrow (RPKM 9.6) and 25 other tissues See more
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Genomic context

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Location:
18p11.32
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (109065..122340)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (262855..276133)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (109065..122340)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene tubulin beta 8B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:78692-79192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:79193-79693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:81490-82403 Neighboring gene Sharpr-MPRA regulatory region 10972 Neighboring gene IL9R pseudogene 4 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:106915-107598 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:107891-108680 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:108681-109468 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:109469-110257 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:110258-111045 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9235 Neighboring gene microRNA 8078 Neighboring gene uncharacterized LOC105371951 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9237 Neighboring gene ubiquitin specific peptidase 14 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:185973-186474 Neighboring gene THO complex subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Little ROCK is a ROCK1 pseudogene expressed in human smooth muscle cells. Montefusco MC, et al. BMC Genet, 2010 Apr 14. PMID 20398283, Free PMC Article
  2. Transcriptional fates of human-specific segmental duplications in brain. Dougherty ML, et al. Genome Res, 2018 Oct. PMID 30228200, Free PMC Article
  3. Genome-wide association study of chronic periodontitis in a general German population. Teumer A, et al. J Clin Periodontol, 2013 Nov. PMID 24024966
  4. Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II. Li Y, et al. Nat Commun, 2018 Oct 22. PMID 30349055, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of chronic periodontitis in a general German population.
EBI GWAS Catalog

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_033770.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001005, BC041849
    Related
    ENST00000608049.5

  2. NR_160777.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    MH721915
    Related
    ENST00000576266.6

  3. NR_160778.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    MH721914, MH721915
    Related
    ENST00000693583.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    109065..122340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    262855..276133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Chemical Information
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