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Rint1 RAD50 interactor 1 [ Mus musculus (house mouse) ]

Gene ID: 72772, updated on 21-Apr-2024

Summary

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Official Symbol
Rint1provided by MGI
Official Full Name
RAD50 interactor 1provided by MGI
Primary source
MGI:MGI:1916233
See related
Ensembl:ENSMUSG00000028999 AllianceGenome:MGI:1916233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rint-1; 1500019C06Rik; 2810450M21Rik
Summary
Predicted to be involved in mitotic G2 DNA damage checkpoint signaling; regulation of ER to Golgi vesicle-mediated transport; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Predicted to be located in endoplasmic reticulum. Predicted to be part of Dsl1/NZR complex. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in infantile liver failure syndrome. Orthologous to human RINT1 (RAD50 interactor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 6.8), limb E14.5 (RPKM 6.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 A3; 5 10.45 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (23992700..24028582)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (23787698..23823584)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene expressed sequence AI506816 Neighboring gene STARR-positive B cell enhancer ABC_E8818 Neighboring gene STARR-positive B cell enhancer ABC_E3564 Neighboring gene predicted gene, 50451 Neighboring gene pseudouridylate synthase 7 Neighboring gene STARR-seq mESC enhancer starr_12621 Neighboring gene STARR-positive B cell enhancer ABC_E4745 Neighboring gene RIKEN cDNA 4933427G23 gene Neighboring gene predicted gene, 22054

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RINT1 functions as a multitasking protein at the crossroads between genomic stability, ER homeostasis, and autophagy. Grigaravicius P, et al. Autophagy, 2016 Aug 2. PMID 27367497, Free PMC Article
  2. RINT-1 serves as a tumor suppressor and maintains Golgi dynamics and centrosome integrity for cell survival. Lin X, et al. Mol Cell Biol, 2007 Jul. PMID 17470549, Free PMC Article
  3. Evaluation of Rint1 as a modifier of intestinal tumorigenesis and cancer risk. Otterpohl KL, et al. PLoS One, 2017. PMID 28264000, Free PMC Article
  4. Genetic mapping of Mom5, a novel modifier of Apc(Min)-induced intestinal tumorigenesis. Oikarinen SI, et al. Carcinogenesis, 2009 Sep. PMID 19574546
  5. RINT1 Loss Impairs Retinogenesis Through TRP53-Mediated Apoptosis. Gomes AL, et al. Front Cell Dev Biol, 2020. PMID 32850831, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RINT1 has a role as a multitasking protein with roles in genomic stability, ER homeostasis, and autophagy
    Title: RINT1 functions as a multitasking protein at the crossroads between genomic stability, ER homeostasis, and autophagy.
  2. these data are more consistent with the hypothesis that RINT1 functions as an oncogene rather than a tumor suppressor gene in the context of colorectal cancer.
    Title: Evaluation of Rint1 as a modifier of intestinal tumorigenesis and cancer risk.
  3. A crucial role of Rint1 in vivo in genomic stability maintenance, as well as in prevention of endoplasmic reticulum stress and autophagy.
    Title: Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain.
  4. These findings suggest that RINT-1 serves as a novel tumor suppressor essential for maintaining the dynamic integrity of the Golgi apparatus and the centrosome, a prerequisite to their proper coordination during cell division.
    Title: RINT-1 serves as a tumor suppressor and maintains Golgi dynamics and centrosome integrity for cell survival.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC183656

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of ER to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Dsl1/NZR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Dsl1/NZR complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RAD50-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310467.1 → NP_001297396.1  RAD50-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001297396.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK005284, AK028707, BC065059
    Consensus CDS
    CCDS80220.1
    UniProtKB/TrEMBL
    B2RWX4
    Related
    ENSMUSP00000110766.3, ENSMUST00000115113.3
    Conserved Domains (1) summary
    pfam04437
    Location:246 → 726
    RINT1_TIP1; RINT-1 / TIP-1 family

  2. NM_177323.4 → NP_796297.2  RAD50-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_796297.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK005284, AK135334, BC065059
    Consensus CDS
    CCDS39025.1
    UniProtKB/Swiss-Prot
    Q3UXS1, Q6P1I2, Q8BZ36, Q8C193
    UniProtKB/TrEMBL
    B2RWX4
    Related
    ENSMUSP00000030852.7, ENSMUST00000030852.13
    Conserved Domains (1) summary
    pfam04437
    Location:304 → 784
    RINT1_TIP1; RINT-1 / TIP-1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    23992700..24028582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165534.1 → XP_036021427.1  RAD50-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    B2RWX4
    Conserved Domains (1) summary
    pfam04437
    Location:168 → 648
    RINT1_TIP1; RINT-1 / TIP-1 family

RNA

  1. XR_001784750.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZ36.2 GenPept UniProtKB/Swiss-Prot:Q8BZ36

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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