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Hdhd3 haloacid dehalogenase-like hydrolase domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 72748, updated on 5-Mar-2024

Summary

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Official Symbol
Hdhd3provided by MGI
Official Full Name
haloacid dehalogenase-like hydrolase domain containing 3provided by MGI
Primary source
MGI:MGI:1919998
See related
Ensembl:ENSMUSG00000038422 AllianceGenome:MGI:1919998
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810435D12Rik
Summary
Predicted to enable hydrolase activity. Located in mitochondrion. Orthologous to human HDHD3 (haloacid dehalogenase like hydrolase domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 5.8), duodenum adult (RPKM 4.5) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 B3; 4 33.16 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (62417291..62420437, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (62499054..62502200, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 31 Neighboring gene B-box and SPRY domain containing Neighboring gene aminolevulinate, delta-, dehydratase Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:62186055-62186242 Neighboring gene polymerase (DNA directed), epsilon 3 (p17 subunit)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
haloacid dehalogenase-like hydrolase domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024257.1 → NP_077219.1  haloacid dehalogenase-like hydrolase domain-containing protein 3

    See identical proteins and their annotated locations for NP_077219.1

    Status: PROVISIONAL

    Source sequence(s)
    BC003491
    Consensus CDS
    CCDS18242.1
    UniProtKB/Swiss-Prot
    Q9CYW4
    Related
    ENSMUSP00000036337.3, ENSMUST00000037820.3
    Conserved Domains (2) summary
    cd01427
    Location:102 → 211
    HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
    TIGR02252
    Location:8 → 210
    DREG-2; REG-2-like, HAD superfamily (subfamily IA) hydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    62417291..62420437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CYW4.1 GenPept UniProtKB/Swiss-Prot:Q9CYW4

Gene LinkOut

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