U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tmem161b transmembrane protein 161B [ Mus musculus (house mouse) ]

Gene ID: 72745, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Tmem161bprovided by MGI
Official Full Name
transmembrane protein 161Bprovided by MGI
Primary source
MGI:MGI:1919995
See related
Ensembl:ENSMUSG00000035762 AllianceGenome:MGI:1919995
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810446P07Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human TMEM161B (transmembrane protein 161B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 10.9), CNS E14 (RPKM 6.9) and 21 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
13 C3; 13 44.2 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (84370415..84444085)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (84222296..84295966)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr13:84325541-84325841 Neighboring gene RIKEN cDNA A230107N01 gene Neighboring gene STARR-positive B cell enhancer ABC_E7261 Neighboring gene predicted gene 8456 Neighboring gene STARR-seq mESC enhancer starr_35162 Neighboring gene predicted gene, 46432 Neighboring gene STARR-seq mESC enhancer starr_35164 Neighboring gene STARR-seq mESC enhancer starr_35165 Neighboring gene predicted gene, 41011 Neighboring gene STARR-seq mESC enhancer starr_35166 Neighboring gene STARR-seq mESC enhancer starr_35167 Neighboring gene STARR-seq mESC enhancer starr_35168 Neighboring gene predicted gene, 34196 Neighboring gene predicted gene, 34246

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Fins, fur, and wings: the study of Tmem161b across species, and what it tells us about its function in the heart. Smith KA, et al. Mamm Genome, 2023 Jun. PMID 37222785, Free PMC Article
  2. TMEM161B modulates radial glial scaffolding in neocortical development. Wang L, et al. Proc Natl Acad Sci U S A, 2023 Jan 24. PMID 36669109, Free PMC Article
  3. TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system. Akula SK, et al. Proc Natl Acad Sci U S A, 2023 Jan 24. PMID 36669111, Free PMC Article
  4. The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm. Koopman CD, et al. Proc Natl Acad Sci U S A, 2021 Mar 2. PMID 33597309, Free PMC Article
  5. Disruption of Visc-2, a Brain-Expressed Conserved Long Noncoding RNA, Does Not Elicit an Overt Anatomical or Behavioral Phenotype. Oliver PL, et al. Cereb Cortex, 2015 Oct. PMID 25209608, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fins, fur, and wings: the study of Tmem161b across species, and what it tells us about its function in the heart.
    Title: Fins, fur, and wings: the study of Tmem161b across species, and what it tells us about its function in the heart.
  2. TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system.
    Title: TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system.
  3. TMEM161B modulates radial glial scaffolding in neocortical development.
    Title: TMEM161B modulates radial glial scaffolding in neocortical development.
  4. The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm.
    Title: The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (3)  1 citation

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in regulation of cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transmembrane protein 161B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361908.1 → NP_001348837.1  transmembrane protein 161B isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC154335, CT033785
    Conserved Domains (1) summary
    pfam10268
    Location:1 → 357
    Tmemb_161AB; Predicted transmembrane protein 161AB

  2. NM_001361909.1 → NP_001348838.1  transmembrane protein 161B isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 2 and 5 both encode the same isoform (c).
    Source sequence(s)
    AC154335, CT033785
    Consensus CDS
    CCDS88497.1
    UniProtKB/TrEMBL
    A0A286YCA7
    Related
    ENSMUSP00000152891.2, ENSMUST00000225069.2
    Conserved Domains (1) summary
    pfam10268
    Location:1 → 303
    Tmemb_161AB; Predicted transmembrane protein 161AB

  3. NM_001361911.1 → NP_001348840.1  transmembrane protein 161B isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 2 and 5 both encode the same isoform (c).
    Source sequence(s)
    AC154335, CT033785
    Consensus CDS
    CCDS88497.1
    UniProtKB/TrEMBL
    A0A286YCA7
    Conserved Domains (1) summary
    pfam10268
    Location:1 → 303
    Tmemb_161AB; Predicted transmembrane protein 161AB

  4. NM_175187.5 → NP_780396.2  transmembrane protein 161B isoform a

    See identical proteins and their annotated locations for NP_780396.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC051663, BM899262, BY239899
    Consensus CDS
    CCDS36739.1
    UniProtKB/Swiss-Prot
    Q8BT72, Q8C2L6
    Related
    ENSMUSP00000055208.8, ENSMUST00000057495.10
    Conserved Domains (1) summary
    pfam10268
    Location:2 → 484
    Tmemb_161AB; Predicted transmembrane protein 161AB

RNA

  1. NR_029419.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, compared to variant 1, which result in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK013305, BC060067, BM899262, BY239899
    Related
    ENSMUST00000223827.2

  2. NR_155262.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC154335, CT033785

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    84370415..84444085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158188.1 → XP_036014081.1  transmembrane protein 161B isoform X1

    UniProtKB/TrEMBL
    A0A286YCA7
    Conserved Domains (1) summary
    pfam10268
    Location:1 → 303
    Tmemb_161AB; Predicted transmembrane protein 161AB

  2. XM_030247423.2 → XP_030103283.1  transmembrane protein 161B isoform X1

    UniProtKB/TrEMBL
    A0A286YCA7
    Conserved Domains (1) summary
    pfam10268
    Location:1 → 303
    Tmemb_161AB; Predicted transmembrane protein 161AB

  3. XM_006517405.4 → XP_006517468.1  transmembrane protein 161B isoform X1

    See identical proteins and their annotated locations for XP_006517468.1

    UniProtKB/TrEMBL
    A0A286YCA7
    Conserved Domains (1) summary
    pfam10268
    Location:1 → 303
    Tmemb_161AB; Predicted transmembrane protein 161AB

  4. XM_006517404.4 → XP_006517467.1  transmembrane protein 161B isoform X1

    See identical proteins and their annotated locations for XP_006517467.1

    UniProtKB/TrEMBL
    A0A286YCA7
    Conserved Domains (1) summary
    pfam10268
    Location:1 → 303
    Tmemb_161AB; Predicted transmembrane protein 161AB

  5. XM_011244565.4 → XP_011242867.1  transmembrane protein 161B isoform X1

    See identical proteins and their annotated locations for XP_011242867.1

    UniProtKB/TrEMBL
    A0A286YCA7
    Conserved Domains (1) summary
    pfam10268
    Location:1 → 303
    Tmemb_161AB; Predicted transmembrane protein 161AB
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C2L6.1 GenPept UniProtKB/Swiss-Prot:Q8C2L6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous