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Cdc42se2 CDC42 small effector 2 [ Mus musculus (house mouse) ]

Gene ID: 72729, updated on 5-Mar-2024

Summary

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Official Symbol
Cdc42se2provided by MGI
Official Full Name
CDC42 small effector 2provided by MGI
Primary source
MGI:MGI:1919979
See related
Ensembl:ENSMUSG00000052298 AllianceGenome:MGI:1919979
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SPEC2; 2810404F18Rik
Summary
Predicted to enable signaling adaptor activity. Predicted to be involved in regulation of signal transduction. Predicted to act upstream of or within phagocytosis and regulation of cell shape. Predicted to be located in several cellular components, including cell projection; cytoplasm; and cytoskeleton. Predicted to be active in plasma membrane. Orthologous to human CDC42SE2 (CDC42 small effector 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 40.6), large intestine adult (RPKM 40.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 32.13 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (54608241..54678549, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (54717415..54787703, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57579 Neighboring gene folliculin interacting protein 1 Neighboring gene predicted gene, 24198 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:54336045-54336232 Neighboring gene STARR-positive B cell enhancer ABC_E6984 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 6 Neighboring gene STARR-seq mESC enhancer starr_29509 Neighboring gene STARR-seq mESC enhancer starr_29510 Neighboring gene predicted gene 12227 Neighboring gene STARR-positive B cell enhancer ABC_E8404 Neighboring gene STARR-positive B cell enhancer ABC_E11480 Neighboring gene STARR-positive B cell enhancer ABC_E6985 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:54615437-54615636 Neighboring gene STARR-positive B cell enhancer ABC_E2988 Neighboring gene STARR-seq mESC enhancer starr_29513 Neighboring gene LYR motif containing 7, opposite strand Neighboring gene LYR motif containing 7 Neighboring gene ATPase family, AAA domain containing 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  2. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phagocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CDC42 small effector protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178626.3 → NP_848741.1  CDC42 small effector protein 2

    See identical proteins and their annotated locations for NP_848741.1

    Status: VALIDATED

    Source sequence(s)
    AK135775, AK160934, BY688282, CJ072588
    Consensus CDS
    CCDS36153.1
    UniProtKB/Swiss-Prot
    Q3UKN9, Q8BGH7
    Related
    ENSMUSP00000070725.7, ENSMUST00000064104.13
    Conserved Domains (1) summary
    cd00132
    Location:27 → 67
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    54608241..54678549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534320.4 → XP_006534383.1  CDC42 small effector protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006534383.1

    UniProtKB/Swiss-Prot
    Q3UKN9, Q8BGH7
    Conserved Domains (1) summary
    cd00132
    Location:27 → 67
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

  2. XM_030246369.2 → XP_030102229.1  CDC42 small effector protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3UKN9, Q8BGH7
    Conserved Domains (1) summary
    cd00132
    Location:27 → 67
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

  3. XM_030246370.1 → XP_030102230.1  CDC42 small effector protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3UKN9, Q8BGH7
    Conserved Domains (1) summary
    cd00132
    Location:27 → 67
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGH7.1 GenPept UniProtKB/Swiss-Prot:Q8BGH7

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