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Zfp74 zinc finger protein 74 [ Mus musculus (house mouse) ]

Gene ID: 72723, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp74provided by MGI
Official Full Name
zinc finger protein 74provided by MGI
Primary source
MGI:MGI:107784
See related
Ensembl:ENSMUSG00000059975 AllianceGenome:MGI:107784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KRAB8; Zfp66; Znf569; mszf21; mszf77; zfp-74; 2810054M15Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus; oocyte; and ureter. Orthologous to human ZNF569 (zinc finger protein 569). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 4.0), CNS E14 (RPKM 3.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B1; 7 17.26 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29632086..29653579, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29932661..29954148, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 27 Neighboring gene STARR-positive B cell enhancer ABC_E9288 Neighboring gene microRNA 7668 Neighboring gene zinc finger protein 383 Neighboring gene STARR-seq mESC enhancer starr_18496 Neighboring gene RIKEN cDNA C230062I16 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:30738577-30738760 Neighboring gene STARR-positive B cell enhancer ABC_E8160 Neighboring gene predicted gene, 57504 Neighboring gene macrophage migration inhibitory factor, pseudogene Neighboring gene predicted gene, 31735 Neighboring gene STARR-seq mESC enhancer starr_18498

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
  2. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
  3. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
  4. Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci. Marine JC, et al. Mamm Genome, 1996 Jun. PMID 8662221
  5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 569

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178384.4 → NP_848471.2  zinc finger protein 569

    See identical proteins and their annotated locations for NP_848471.2

    Status: VALIDATED

    Source sequence(s)
    AC149283
    Consensus CDS
    CCDS39874.1
    UniProtKB/Swiss-Prot
    E9QK35, O88237, Q80W31
    Related
    ENSMUSP00000103840.2, ENSMUST00000108205.9
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:205 → 638
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:433 → 453
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:641 → 666
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    29632086..29653579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540385.5 → XP_006540448.1  zinc finger protein 569 isoform X1

    See identical proteins and their annotated locations for XP_006540448.1

    UniProtKB/Swiss-Prot
    E9QK35, O88237, Q80W31
    Related
    ENSMUSP00000032797.9, ENSMUST00000032797.9
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:205 → 638
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:433 → 453
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:641 → 666
    zf-H2C2_2; Zinc-finger double domain

  2. XM_011250720.4 → XP_011249022.1  zinc finger protein 569 isoform X1

    See identical proteins and their annotated locations for XP_011249022.1

    UniProtKB/Swiss-Prot
    E9QK35, O88237, Q80W31
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:205 → 638
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:433 → 453
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:641 → 666
    zf-H2C2_2; Zinc-finger double domain

  3. XM_036153463.1 → XP_036009356.1  zinc finger protein 569 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:79 → 512
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:307 → 327
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:515 → 540
    zf-H2C2_2; Zinc-finger double domain

  4. XM_030243015.2 → XP_030098875.1  zinc finger protein 569 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:79 → 512
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:307 → 327
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:515 → 540
    zf-H2C2_2; Zinc-finger double domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001357888.1: Suppressed sequence

    Description
    NM_001357888.1: This RefSeq was removed because it was redundant with an existing RefSeq which alignment software didn''t properly align to the reference genome.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80W31.2 GenPept UniProtKB/Swiss-Prot:Q80W31

Gene LinkOut

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