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Zfp248 zinc finger protein 248 [ Mus musculus (house mouse) ]

Gene ID: 72720, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp248provided by MGI
Official Full Name
zinc finger protein 248provided by MGI
Primary source
MGI:MGI:1919970
See related
Ensembl:ENSMUSG00000030145 AllianceGenome:MGI:1919970
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810037F07Rik; E130106N01Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Is expressed in limb and trunk somite. Orthologous to human ZNF248 (zinc finger protein 248). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 2.7), CNS E18 (RPKM 2.6) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 F1; 6 55.86 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (118404280..118432660, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (118427319..118455699, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30498 Neighboring gene STARR-seq mESC enhancer starr_17136 Neighboring gene BMS1, ribosome biogenesis factor Neighboring gene zinc finger protein 9 Neighboring gene zinc finger protein 248 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC100019

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 248

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361899.1 → NP_001348828.1  zinc finger protein 248 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AC140192
    Consensus CDS
    CCDS90111.1
    UniProtKB/TrEMBL
    Q9CZ86
    Conserved Domains (3) summary
    COG5048
    Location:302 → 368
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:390 → 410
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:430 → 455
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001361900.1 → NP_001348829.1  zinc finger protein 248 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AC140192, AK012874, BC082571
    Consensus CDS
    CCDS90111.1
    UniProtKB/TrEMBL
    Q9CZ86
    Related
    ENSMUSP00000124539.2, ENSMUST00000161519.8
    Conserved Domains (3) summary
    COG5048
    Location:302 → 368
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:390 → 410
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:430 → 455
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001361901.1 → NP_001348830.1  zinc finger protein 248 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AC140192, BC082571, CA750367
    Consensus CDS
    CCDS90111.1
    UniProtKB/TrEMBL
    Q9CZ86
    Conserved Domains (3) summary
    COG5048
    Location:302 → 368
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:390 → 410
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:430 → 455
    zf-H2C2_2; Zinc-finger double domain

  4. NM_028335.2 → NP_082611.1  zinc finger protein 248 isoform a

    See identical proteins and their annotated locations for NP_082611.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC140192, BC082571
    Consensus CDS
    CCDS51884.1
    UniProtKB/TrEMBL
    Q640N4
    Related
    ENSMUSP00000068807.8, ENSMUST00000069292.14
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:403 → 469
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:491 → 511
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:531 → 556
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    118404280..118432660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152325.1 → XP_036008218.1  zinc finger protein 248 isoform X1

    UniProtKB/TrEMBL
    Q640N4
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:403 → 469
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:491 → 511
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:531 → 556
    zf-H2C2_2; Zinc-finger double domain

  2. XM_006506676.3 → XP_006506739.1  zinc finger protein 248 isoform X1

    See identical proteins and their annotated locations for XP_006506739.1

    UniProtKB/TrEMBL
    Q640N4
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:403 → 469
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:491 → 511
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:531 → 556
    zf-H2C2_2; Zinc-finger double domain

  3. XM_036152327.1 → XP_036008220.1  zinc finger protein 248 isoform X2

    UniProtKB/TrEMBL
    Q9CZ86
    Conserved Domains (3) summary
    COG5048
    Location:302 → 368
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:390 → 410
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:430 → 455
    zf-H2C2_2; Zinc-finger double domain

  4. XM_036152328.1 → XP_036008221.1  zinc finger protein 248 isoform X2

    UniProtKB/TrEMBL
    Q9CZ86
    Conserved Domains (3) summary
    COG5048
    Location:302 → 368
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:390 → 410
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:430 → 455
    zf-H2C2_2; Zinc-finger double domain

  5. XM_030255603.1 → XP_030111463.1  zinc finger protein 248 isoform X2

    UniProtKB/TrEMBL
    Q9CZ86
    Conserved Domains (3) summary
    COG5048
    Location:302 → 368
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:390 → 410
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:430 → 455
    zf-H2C2_2; Zinc-finger double domain

  6. XM_036152326.1 → XP_036008219.1  zinc finger protein 248 isoform X2

    UniProtKB/TrEMBL
    Q9CZ86
    Conserved Domains (3) summary
    COG5048
    Location:302 → 368
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:390 → 410
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:430 → 455
    zf-H2C2_2; Zinc-finger double domain

  7. XM_030255604.2 → XP_030111464.1  zinc finger protein 248 isoform X2

    UniProtKB/TrEMBL
    Q9CZ86
    Conserved Domains (3) summary
    COG5048
    Location:302 → 368
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:390 → 410
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:430 → 455
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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