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Adipor1 adiponectin receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 72674, updated on 21-Apr-2024

Summary

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Official Symbol
Adipor1provided by MGI
Official Full Name
adiponectin receptor 1provided by MGI
Primary source
MGI:MGI:1919924
See related
Ensembl:ENSMUSG00000026457 AllianceGenome:MGI:1919924
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Paqr1; ACDCR1; CGI-45; 2810031L11Rik
Summary
This gene encodes a receptor for the fat-derived hormone adiponectin. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. Homozygous knockout mice for this gene exhibit elevated plasma glucose and insulin levels as well as impaired glucose tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in adrenal adult (RPKM 87.2), colon adult (RPKM 63.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 58.22 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134343116..134361089)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134415378..134433351)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02326 Neighboring gene MGAT4 family, member F Neighboring gene STARR-seq mESC enhancer starr_02328 Neighboring gene cytochrome b5 reductase 1 Neighboring gene STARR-seq mESC enhancer starr_02333 Neighboring gene kelch-like 12 Neighboring gene STARR-positive B cell enhancer ABC_E3304 Neighboring gene RAB interacting factor Neighboring gene predicted gene, 25612

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeting Adiponectin Receptor 1 Phosphorylation Against Ischemic Heart Failure. Zhu D, et al. Circ Res, 2022 Jul 8. PMID 35611695, Free PMC Article
  2. Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision. Lewandowski D, et al. JCI Insight, 2022 Feb 22. PMID 35015730, Free PMC Article
  3. Estradiol overcomes adiponectin-resistance in diabetic mice by regulating skeletal muscle adiponectin receptor 1 expression. Chattopadhyay S, et al. Mol Cell Endocrinol, 2022 Jan 15. PMID 34856343
  4. Lung Regulatory T Cells Express Adiponectin Receptor 1: Modulation by Obesity and Airway Allergic Inflammation. Ramos-Ramírez P, et al. Int J Mol Sci, 2020 Nov 26. PMID 33256137, Free PMC Article
  5. Critical Role of AdipoR1 in Regulating Th17 Cell Differentiation Through Modulation of HIF-1α-Dependent Glycolysis. Zhang Q, et al. Front Immunol, 2020. PMID 32973810, Free PMC Article

See all (128) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Decreased AdipoR1 signaling and its implications for obesity-induced male infertility.
    Title: Decreased AdipoR1 signaling and its implications for obesity-induced male infertility.
  2. Adiponectin receptor 1-mediated stimulation of Cav3.2 channels in trigeminal ganglion neurons induces nociceptive behaviors in mice.
    Title: Adiponectin receptor 1-mediated stimulation of Cav3.2 channels in trigeminal ganglion neurons induces nociceptive behaviors in mice.
  3. Targeting Adiponectin Receptor 1 Phosphorylation Against Ischemic Heart Failure.
    Title: Targeting Adiponectin Receptor 1 Phosphorylation Against Ischemic Heart Failure.
  4. Estradiol overcomes adiponectin-resistance in diabetic mice by regulating skeletal muscle adiponectin receptor 1 expression.
    Title: Estradiol overcomes adiponectin-resistance in diabetic mice by regulating skeletal muscle adiponectin receptor 1 expression.
  5. Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision.
    Title: Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision.
  6. Genetic Interaction between Mfrp and Adipor1 Mutations Affect Retinal Disease Phenotypes.
    Title: Genetic Interaction between Mfrp and Adipor1 Mutations Affect Retinal Disease Phenotypes.
  7. Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons.
    Title: Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons.
  8. Adiponectin inhibits Dgalinduced cardiomyocyte senescence via AdipoR1/APPL1.
    Title: Adiponectin inhibits D‑gal‑induced cardiomyocyte senescence via AdipoR1/APPL1.
  9. ADIPOR1 deficiency-induced suppression of retinal ELOVL2 and docosahexaenoic acid levels during photoreceptor degeneration and visual loss.
    Title: ADIPOR1 deficiency-induced suppression of retinal ELOVL2 and docosahexaenoic acid levels during photoreceptor degeneration and visual loss.
  10. Adiponectin exacerbates influenza infection in elderly individuals via IL-18.
    Title: Adiponectin exacerbates influenza infection in elderly individuals via IL-18.
Submit: New GeneRIF Correction See all GeneRIFs (84)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adipokinetic hormone receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables adiponectin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables adiponectin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in adiponectin-activated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within adiponectin-activated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adiponectin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adiponectin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hormone-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in hormone-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in leptin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adiponectin receptor protein 1
Names
progestin and adipoQ receptor family member 1
progestin and adipoQ receptor family member I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306069.1 → NP_001292998.1  adiponectin receptor protein 1

    See identical proteins and their annotated locations for NP_001292998.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC131592, AK143680, AW047193, AY424290, CK623806
    Consensus CDS
    CCDS15309.1
    UniProtKB/Swiss-Prot
    Q91VH1, Q9CZA0
    UniProtKB/TrEMBL
    Q3TI02, Q3UPA4, Q53YY4
    Related
    ENSMUSP00000107856.2, ENSMUST00000112237.2
    Conserved Domains (1) summary
    pfam03006
    Location:129 → 352
    HlyIII; Haemolysin-III related

  2. NM_028320.4 → NP_082596.2  adiponectin receptor protein 1

    See identical proteins and their annotated locations for NP_082596.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC131592, AK143680, AW047193, AY424290, CA945374
    Consensus CDS
    CCDS15309.1
    UniProtKB/Swiss-Prot
    Q91VH1, Q9CZA0
    UniProtKB/TrEMBL
    Q3TI02, Q3UPA4, Q53YY4
    Related
    ENSMUSP00000027727.9, ENSMUST00000027727.15
    Conserved Domains (1) summary
    pfam03006
    Location:129 → 352
    HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    134343116..134361089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VH1.1 GenPept UniProtKB/Swiss-Prot:Q91VH1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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