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Zfp655 zinc finger protein 655 [ Mus musculus (house mouse) ]

Gene ID: 72611, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp655provided by MGI
Official Full Name
zinc finger protein 655provided by MGI
Primary source
MGI:MGI:1919861
See related
Ensembl:ENSMUSG00000007812 AllianceGenome:MGI:1919861
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2700038I16Rik; 9030409O18Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of G1/S transition of mitotic cell cycle and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleolus. Predicted to be active in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ZNF655 (zinc finger protein 655). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 15.2), bladder adult (RPKM 6.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 85.17 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (145168503..145184116)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (145231595..145247306)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zinc finger with KRAB and SCAN domains 14 Neighboring gene STARR-positive B cell enhancer ABC_E1316 Neighboring gene STARR-positive B cell enhancer ABC_E533 Neighboring gene zinc finger with KRAB and SCAN domains 5 Neighboring gene STARR-positive B cell enhancer ABC_E4805 Neighboring gene predicted gene 9710 Neighboring gene STARR-positive B cell enhancer ABC_E6398 Neighboring gene zinc finger and SCAN domain containing 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Kajimura S, et al. Nature, 2009 Aug 27. PMID 19641492, Free PMC Article
  2. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
  3. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article
  4. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
  5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4222

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 655

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083958.2 → NP_001077427.1  zinc finger protein 655 isoform b

    See identical proteins and their annotated locations for NP_001077427.1

    Status: VALIDATED

    Source sequence(s)
    AK161949
    Consensus CDS
    CCDS51698.1
    UniProtKB/TrEMBL
    Q6P8W7
    Related
    ENSMUSP00000143198.2, ENSMUST00000200039.5
    Conserved Domains (1) summary
    pfam01352
    Location:77 → 117
    KRAB; KRAB box

  2. NM_001347533.2 → NP_001334462.1  zinc finger protein 655 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC127411
    Consensus CDS
    CCDS84998.1
    UniProtKB/TrEMBL
    A0A0G2JEM1
    Related
    ENSMUSP00000142825.2, ENSMUST00000199003.5

  3. NM_001363449.1 → NP_001350378.1  zinc finger protein 655 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC127411, AK018500, AK161949
    Consensus CDS
    CCDS90015.1
    UniProtKB/TrEMBL
    A0A0G2JE56
    Related
    ENSMUSP00000142639.2, ENSMUST00000196069.5

  4. NM_001363451.1 → NP_001350380.1  zinc finger protein 655 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC127411
    Conserved Domains (3) summary
    COG5048
    Location:206 → 274
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:169 → 189
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:303 → 323
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001363452.1 → NP_001350381.1  zinc finger protein 655 isoform f

    Status: VALIDATED

    Source sequence(s)
    AK161949, BG078636, BY717878
    UniProtKB/TrEMBL
    F7AFH2
    Related
    ENSMUSP00000082803.9, ENSMUST00000085661.9

  6. NM_028298.4 → NP_082574.1  zinc finger protein 655 isoform a

    See identical proteins and their annotated locations for NP_082574.1

    Status: VALIDATED

    Source sequence(s)
    AC127411
    Consensus CDS
    CCDS19861.1
    UniProtKB/TrEMBL
    Q5DTG8, Q9CZP3
    Related
    ENSMUSP00000128969.2, ENSMUST00000167316.8
    Conserved Domains (3) summary
    COG5048
    Location:400 → 468
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:363 → 383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:334 → 356
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    145168503..145184116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165532.1 → XP_036021425.1  zinc finger protein 655 isoform X1

    UniProtKB/TrEMBL
    Q5DTG8, Q9CZP3
    Conserved Domains (3) summary
    COG5048
    Location:400 → 468
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:363 → 383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:334 → 356
    zf-C2H2; Zinc finger, C2H2 type

  2. XM_017321114.3 → XP_017176603.1  zinc finger protein 655 isoform X1

    UniProtKB/TrEMBL
    Q5DTG8, Q9CZP3
    Conserved Domains (3) summary
    COG5048
    Location:400 → 468
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:363 → 383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:334 → 356
    zf-C2H2; Zinc finger, C2H2 type

  3. XM_030254832.1 → XP_030110692.1  zinc finger protein 655 isoform X2

    UniProtKB/TrEMBL
    Q6P8W7
    Conserved Domains (1) summary
    pfam01352
    Location:77 → 117
    KRAB; KRAB box
Nucleotide Protein Strain
Heading Accession and Version

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