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Car10 carbonic anhydrase 10 [ Mus musculus (house mouse) ]

Gene ID: 72605, updated on 5-Mar-2024

Summary

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Official Symbol
Car10provided by MGI
Official Full Name
carbonic anhydrase 10provided by MGI
Primary source
MGI:MGI:1919855
See related
Ensembl:ENSMUSG00000056158 AllianceGenome:MGI:1919855
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ca10; 2700029L05Rik
Summary
Predicted to enable hydro-lyase activity. Predicted to be involved in one-carbon metabolic process. Is expressed in several structures, including cardiovascular system; central nervous system; foregut; integumental system; and respiratory system. Orthologous to human CA10 (carbonic anhydrase 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 15.9), cortex adult (RPKM 14.4) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 58.43 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (92988807..93492577)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (93096805..93601751)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30433 Neighboring gene YKT6 homolog pseudogene Neighboring gene predicted gene, 25113 Neighboring gene STARR-seq mESC enhancer starr_30434 Neighboring gene STARR-seq mESC enhancer starr_30435 Neighboring gene predicted gene, 35002 Neighboring gene predicted gene, 24856 Neighboring gene STARR-seq mESC enhancer starr_30437 Neighboring gene STARR-seq mESC enhancer starr_30439 Neighboring gene 60S ribosomal protein L26-like Neighboring gene predicted gene 11502

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Carbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligand. Sterky FH, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28154140, Free PMC Article
  2. cDNA cloning and developmental expression of murine carbonic anhydrase-related proteins VIII, X, and XI. Taniuchi K, et al. Brain Res Mol Brain Res, 2002 Dec 30. PMID 12531530
  3. Mapping blood pressure loci in (A/J x B6)F2 mice. Woo DD, et al. Physiol Genomics, 2003 Nov 11. PMID 14612590
  4. A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development. Wu L, et al. Dev Dyn, 2013 Mar. PMID 23233153
  5. Nucleome Dynamics during Retinal Development. Norrie JL, et al. Neuron, 2019 Nov 6. PMID 31493975, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CA10 directly binds in a cis configuration to a conserved membrane-proximal, extracellular sequence of alpha- and beta-neurexins.
    Title: Carbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligand.
  2. Results describe the tissue distribution of carbonic anhydrase-related proteins VIII, X, and XI and their developmental expression in the murine embryonic brain.
    Title: cDNA cloning and developmental expression of murine carbonic anhydrase-related proteins VIII, X, and XI.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbonate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydro-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in one-carbon metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
carbonic anhydrase-related protein 10
Names
CA-RP X
CARP X
carbonic anhydrase-related protein X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361707.1 → NP_001348636.1  carbonic anhydrase-related protein 10 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AL683819, AL713960, AL731728, AL731849, AL954830
    Consensus CDS
    CCDS25244.1
    UniProtKB/Swiss-Prot
    P61215
    UniProtKB/TrEMBL
    Q3V1V7, Q6NZJ2
    Related
    ENSMUSP00000103490.3, ENSMUST00000107858.9
    Conserved Domains (1) summary
    cd03121
    Location:46 → 302
    alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...

  2. NM_001361708.1 → NP_001348637.1  carbonic anhydrase-related protein 10 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AL683819, AL713960, AL731728, AL731849, AL954830
    Consensus CDS
    CCDS25244.1
    UniProtKB/Swiss-Prot
    P61215
    UniProtKB/TrEMBL
    Q3V1V7, Q6NZJ2
    Related
    ENSMUSP00000035585.7, ENSMUST00000042943.13
    Conserved Domains (1) summary
    cd03121
    Location:46 → 302
    alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...

  3. NM_028296.3 → NP_082572.1  carbonic anhydrase-related protein 10 precursor

    See identical proteins and their annotated locations for NP_082572.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK036003, AK132222, CJ280653
    Consensus CDS
    CCDS25244.1
    UniProtKB/Swiss-Prot
    P61215
    UniProtKB/TrEMBL
    Q3V1V7, Q6NZJ2
    Related
    ENSMUSP00000103495.3, ENSMUST00000107863.4
    Conserved Domains (1) summary
    cd03121
    Location:46 → 302
    alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    92988807..93492577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246367.2 → XP_030102227.1  carbonic anhydrase-related protein 10 isoform X1

    UniProtKB/Swiss-Prot
    P61215
    UniProtKB/TrEMBL
    Q3V1V7, Q6NZJ2
    Conserved Domains (1) summary
    cd03121
    Location:46 → 302
    alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...

  2. XM_030246368.2 → XP_030102228.1  carbonic anhydrase-related protein 10 isoform X1

    UniProtKB/Swiss-Prot
    P61215
    UniProtKB/TrEMBL
    Q3V1V7, Q6NZJ2
    Conserved Domains (1) summary
    cd03121
    Location:46 → 302
    alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61215.1 GenPept UniProtKB/Swiss-Prot:P61215

Gene LinkOut

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