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Pdia5 protein disulfide isomerase associated 5 [ Mus musculus (house mouse) ]

Gene ID: 72599, updated on 30-Apr-2024

Summary

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Official Symbol
Pdia5provided by MGI
Official Full Name
protein disulfide isomerase associated 5provided by MGI
Primary source
MGI:MGI:1919849
See related
Ensembl:ENSMUSG00000022844 AllianceGenome:MGI:1919849
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pdir; 2700053F16Rik
Summary
Predicted to enable protein disulfide isomerase activity and protein-disulfide reductase activity. Predicted to be involved in protein folding. Predicted to be located in endoplasmic reticulum. Is expressed in clavicle; mandible; maxilla; orbito-sphenoid; and rib. Orthologous to human PDIA5 (protein disulfide isomerase family A member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 48.4), liver E18 (RPKM 23.7) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B3; 16 25.37 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (35217678..35311289, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (35397308..35490919, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25079 Neighboring gene predicted gene, 23518 Neighboring gene STARR-seq mESC enhancer starr_40738 Neighboring gene RIKEN cDNA 1600019K03 gene Neighboring gene PRAME family member 8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pan-Cancer Analysis of the Immunological Role of PDIA5: A Potential Target for Immunotherapy. Chen Y, et al. Front Immunol, 2022. PMID 36003400, Free PMC Article
  2. Unfolded protein response is not activated in the mucopolysaccharidoses but protein disulfide isomerase 5 is deregulated. Villani GR, et al. J Inherit Metab Dis, 2012 May. PMID 22002444
  3. Molecular cloning of the cDNA encoding a novel protein disulfide isomerase-related protein (PDIR). Hayano T, et al. FEBS Lett, 1995 Sep 25. PMID 7556671
  4. The protein disulphide-isomerase family: unravelling a string of folds. Ferrari DM, et al. Biochem J, 1999 Apr 1. PMID 10085220, Free PMC Article
  5. Proteins of the PDI family: unpredicted non-ER locations and functions. Turano C, et al. J Cell Physiol, 2002 Nov. PMID 12384992

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pan-Cancer Analysis of the Immunological Role of PDIA5: A Potential Target for Immunotherapy.
    Title: Pan-Cancer Analysis of the Immunological Role of PDIA5: A Potential Target for Immunotherapy.
  2. protein disulfide isomerase 5 is deregulated in the mucopolysaccharidoses, although the unfolded protein response is not activated
    Title: Unfolded protein response is not activated in the mucopolysaccharidoses but protein disulfide isomerase 5 is deregulated.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein disulfide isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-disulfide reductase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein disulfide-isomerase A5
Names
protein disulfide isomerase-related protein
NP_082571.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028295.1 → NP_082571.1  protein disulfide-isomerase A5 precursor

    See identical proteins and their annotated locations for NP_082571.1

    Status: PROVISIONAL

    Source sequence(s)
    BC009151
    Consensus CDS
    CCDS37323.1
    UniProtKB/Swiss-Prot
    Q921X9
    Related
    ENSMUSP00000023550.8, ENSMUST00000023550.9
    Conserved Domains (3) summary
    cd02997
    Location:396 → 499
    PDI_a_PDIR; PDIa family, PDIR subfamily; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. Similar to PDI, it is involved ...
    cd03067
    Location:26 → 137
    PDI_b_PDIR_N; PDIb family, PDIR subfamily, N-terminal TRX-like b domain; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. ...
    PTZ00102
    Location:122 → 517
    PTZ00102; disulphide isomerase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    35217678..35311289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004939233.1 RNA Sequence

  2. XR_384604.4 RNA Sequence

  3. XR_384603.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921X9.1 GenPept UniProtKB/Swiss-Prot:Q921X9

Gene LinkOut

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