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Spats2 spermatogenesis associated, serine-rich 2 [ Mus musculus (house mouse) ]

Gene ID: 72572, updated on 5-Mar-2024

Summary

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Official Symbol
Spats2provided by MGI
Official Full Name
spermatogenesis associated, serine-rich 2provided by MGI
Primary source
MGI:MGI:1919822
See related
Ensembl:ENSMUSG00000051934 AllianceGenome:MGI:1919822
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p59; 59kDa; Scr59; p59scr; 2700012F11Rik
Summary
Located in cytoplasm. Orthologous to human SPATS2 (spermatogenesis associated serine rich 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 21.6), placenta adult (RPKM 20.3) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 F1; 15 56.01 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99023783..99111096)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99125926..99213215)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene complement component 1, q subcomponent-like 4 Neighboring gene DnaJ heat shock protein family (Hsp40) member C22 Neighboring gene predicted gene, 57817 Neighboring gene predicted gene, 25183 Neighboring gene STARR-seq mESC enhancer starr_39699 Neighboring gene predicted gene, 46538 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 3 Neighboring gene RIKEN cDNA 1700120C14 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:99082061-99082244 Neighboring gene STARR-positive B cell enhancer ABC_E1486 Neighboring gene microspherule protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of a novel protein p59(scr), which is expressed at specific stages of mouse spermatogenesis. Senoo M, et al. Biochem Biophys Res Commun, 2002 Apr 12. PMID 11944913
  2. Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism. Valdez-Sinon AN, et al. iScience, 2020 May 22. PMID 32434143, Free PMC Article
  3. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
  4. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
  5. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
spermatogenesis-associated serine-rich protein 2
Names
serine-rich spermatocytes and round spermatid 59 kDa protein
serine-rich spermatocytes and round spermatid protein, 59kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418664.1 → NP_001405593.1  spermatogenesis-associated serine-rich protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157610, AC161198
    UniProtKB/Swiss-Prot
    Q3UX77, Q8C810, Q8K1N4, Q8R1P6

  2. NM_001418665.1 → NP_001405594.1  spermatogenesis-associated serine-rich protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157610, AC161198
    UniProtKB/Swiss-Prot
    Q3UX77, Q8C810, Q8K1N4, Q8R1P6

  3. NM_001418666.1 → NP_001405595.1  spermatogenesis-associated serine-rich protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157610, AC161198

  4. NM_001418667.1 → NP_001405596.1  spermatogenesis-associated serine-rich protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157610, AC161198

  5. NM_001418668.1 → NP_001405597.1  spermatogenesis-associated serine-rich protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157610, AC161198

  6. NM_001418669.1 → NP_001405598.1  spermatogenesis-associated serine-rich protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157610, AC161198

  7. NM_001418670.1 → NP_001405599.1  spermatogenesis-associated serine-rich protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157610, AC161198

  8. NM_139140.2 → NP_631879.1  spermatogenesis-associated serine-rich protein 2 isoform 1

    See identical proteins and their annotated locations for NP_631879.1

    Status: VALIDATED

    Source sequence(s)
    AC157610, AC161198
    Consensus CDS
    CCDS27816.1
    UniProtKB/Swiss-Prot
    Q3UX77, Q8C810, Q8K1N4, Q8R1P6
    Related
    ENSMUSP00000070549.5, ENSMUST00000063517.6
    Conserved Domains (1) summary
    pfam07139
    Location:81 → 385
    DUF1387; Protein of unknown function (DUF1387)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    99023783..99111096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245737.1 → XP_011244039.1  spermatogenesis-associated serine-rich protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011244039.1

    UniProtKB/Swiss-Prot
    Q3UX77, Q8C810, Q8K1N4, Q8R1P6
    Conserved Domains (1) summary
    pfam07139
    Location:81 → 385
    DUF1387; Protein of unknown function (DUF1387)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1N4.1 GenPept UniProtKB/Swiss-Prot:Q8K1N4

Gene LinkOut

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