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Pgam5 phosphoglycerate mutase family member 5 [ Mus musculus (house mouse) ]

Gene ID: 72542, updated on 17-Mar-2024

Summary

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Official Symbol
Pgam5provided by MGI
Official Full Name
phosphoglycerate mutase family member 5provided by MGI
Primary source
MGI:MGI:1919792
See related
Ensembl:ENSMUSG00000029500 AllianceGenome:MGI:1919792
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610528A17Rik
Summary
Predicted to enable GTPase activator activity and protein serine/threonine phosphatase activity. Involved in necroptotic process and negative regulation of cold-induced thermogenesis. Predicted to be located in mitochondrial outer membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Orthologous to human PGAM5 (PGAM family member 5, mitochondrial serine/threonine protein phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 16.9), CNS E18 (RPKM 16.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pgam5 in Genome Data Viewer
Location:
5 F; 5 53.43 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110407001..110417765, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110259135..110269899, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene golgin A3 Neighboring gene uncharacterized LOC118568795 Neighboring gene STARR-seq mESC enhancer starr_13947 Neighboring gene ankyrin repeat and LEM domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_13949 Neighboring gene STARR-positive B cell enhancer ABC_E6363 Neighboring gene peroxisomal membrane protein 2 Neighboring gene polymerase (DNA directed), epsilon Neighboring gene predicted gene, 26277

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phosphoglycerate mutase 5 facilitates mitochondrial dysfunction and neuroinflammation in spinal tissues after spinal cord injury. Dai C, et al. Int Immunopharmacol, 2023 Mar. PMID 36773566
  2. Phosphoglycerate mutase 5 initiates inflammation in acute kidney injury by triggering mitochondrial DNA release by dephosphorylating the pro-apoptotic protein Bax. Li J, et al. Kidney Int, 2023 Jan. PMID 36089186
  3. Phosphoglycerate mutase 5 exacerbates cardiac ischemia-reperfusion injury through disrupting mitochondrial quality control. Zhu H, et al. Redox Biol, 2021 Jan. PMID 33166869, Free PMC Article
  4. Butylphthalide ameliorates experimental autoimmune encephalomyelitis by suppressing PGAM5-induced necroptosis and inflammation in microglia. Wang Y, et al. Biochem Biophys Res Commun, 2018 Feb 26. PMID 29407174
  5. PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury. He GW, et al. Gut, 2017 Apr. PMID 27566130

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphoglycerate mutase 5 aggravates alcoholic liver disease through disrupting VDAC-1-dependent mitochondrial integrity.
    Title: Phosphoglycerate mutase 5 aggravates alcoholic liver disease through disrupting VDAC-1-dependent mitochondrial integrity.
  2. Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis.
    Title: Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis.
  3. PGAM5 knockout causes depressive-like behaviors in mice via ATP deficiency in the prefrontal cortex.
    Title: PGAM5 knockout causes depressive-like behaviors in mice via ATP deficiency in the prefrontal cortex.
  4. Pgam5-mediated PHB2 dephosphorylation contributes to endotoxemia-induced myocardial dysfunction by inhibiting mitophagy and the mitochondrial unfolded protein response.
    Title: Pgam5-mediated PHB2 dephosphorylation contributes to endotoxemia-induced myocardial dysfunction by inhibiting mitophagy and the mitochondrial unfolded protein response.
  5. Phosphoglycerate mutase 5 facilitates mitochondrial dysfunction and neuroinflammation in spinal tissues after spinal cord injury.
    Title: Phosphoglycerate mutase 5 facilitates mitochondrial dysfunction and neuroinflammation in spinal tissues after spinal cord injury.
  6. Phosphoglycerate mutase 5 initiates inflammation in acute kidney injury by triggering mitochondrial DNA release by dephosphorylating the pro-apoptotic protein Bax.
    Title: Phosphoglycerate mutase 5 initiates inflammation in acute kidney injury by triggering mitochondrial DNA release by dephosphorylating the pro-apoptotic protein Bax.
  7. E3 ubiquitin ligase ring finger protein 5 protects against hepatic ischemia reperfusion injury by mediating phosphoglycerate mutase family member 5 ubiquitination.
    Title: E3 ubiquitin ligase ring finger protein 5 protects against hepatic ischemia reperfusion injury by mediating phosphoglycerate mutase family member 5 ubiquitination.
  8. NR4A1 Promotes LPS-Induced Acute Lung Injury through Inhibition of Opa1-Mediated Mitochondrial Fusion and Activation of PGAM5-Related Necroptosis.
    Title: NR4A1 Promotes LPS-Induced Acute Lung Injury through Inhibition of Opa1-Mediated Mitochondrial Fusion and Activation of PGAM5-Related Necroptosis.
  9. Phosphoglycerate Mutase 5 Knockdown Alleviates Neuronal Injury After Traumatic Brain Injury Through Drp1-Mediated Mitochondrial Dysfunction.
    Title: Phosphoglycerate Mutase 5 Knockdown Alleviates Neuronal Injury After Traumatic Brain Injury Through Drp1-Mediated Mitochondrial Dysfunction.
  10. Phosphoglycerate mutase 5 exacerbates cardiac ischemia-reperfusion injury through disrupting mitochondrial quality control.
    Title: Phosphoglycerate mutase 5 exacerbates cardiac ischemia-reperfusion injury through disrupting mitochondrial quality control.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in necroptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in necroptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-threonine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within programmed cell death IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase PGAM5, mitochondrial
NP_001157010.1
NP_082549.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163538.1 → NP_001157010.1  serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_001157010.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC052179, BY101410, BY620990
    Consensus CDS
    CCDS51606.1
    UniProtKB/Swiss-Prot
    B2RSM6, Q3UK19, Q80VY8, Q8BM78, Q8BX10, Q9CZU2
    UniProtKB/TrEMBL
    B7ZNW0
    Related
    ENSMUSP00000108124.3, ENSMUST00000112505.9
    Conserved Domains (1) summary
    cd07067
    Location:98 → 271
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

  2. NM_028273.3 → NP_082549.2  serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_082549.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, which results in a protein (isoform 2) which is 1 amino acid shorter than isoform 1.
    Source sequence(s)
    AK034588, BC138925, BY101410, BY620990
    Consensus CDS
    CCDS19523.1
    UniProtKB/TrEMBL
    B7ZNW0
    Related
    ENSMUSP00000057760.9, ENSMUST00000059229.16
    Conserved Domains (1) summary
    cd07067
    Location:98 → 270
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    110407001..110417765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BX10.1 GenPept UniProtKB/Swiss-Prot:Q8BX10

Gene LinkOut

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