Tagap T cell activation Rho GTPase activating protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tagapprovided by MGI
Official Full Name: T cell activation Rho GTPase activating proteinprovided by MGI
Primary source: MGI:MGI:3615484
See related: Ensembl:ENSMUSG00000033450 AllianceGenome:MGI:3615484
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TRD; Tcd1; tcs1; Tcd-1; Tcd1a; tcs-1; 2610315E15Rik
Summary: Predicted to enable GTPase activator activity. Acts upstream of or within defense response to virus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus 21. Orthologous to human TAGAP (T cell activation RhoGTPase activating protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 13.2), thymus adult (RPKM 13.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A1; 17 4.82 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (8144832..8153729)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (7926000..7934897)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TAGAP expression influences CD4+ T cell differentiation, immune infiltration, and cytotoxicity in LUAD through the STAT pathway: implications for immunotherapy.
Title: TAGAP expression influences CD4+ T cell differentiation, immune infiltration, and cytotoxicity in LUAD through the STAT pathway: implications for immunotherapy.
TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response.
Title: TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response.
Loss of Tagap in mice suppressed the sema3E- and plexin-D1-mediated release of thymocytes that adhered within the cortex through beta1-containing integrins. This suppression led to the impaired translocation of thymocytes from the cortex to the medulla and resulted in the formation of ectopic medullary structures within the thymic cortex leading to autoimmune disorders.
Title: Regulation of thymocyte trafficking by Tagap, a GAP domain protein linked to human autoimmunity.
These findings indicate that increased TAGAP expression is a distinguishing feature of inflammatory disease and further highlight the role of TAGAP in rheumatoid arthritis susceptibility.
Title: T cell activation Rho GTPase activating protein (TAGAP) is upregulated in clinical and experimental arthritis.
these studies demonstrated that TAGAP was required for TH17 differentiation in vitro and that the loss of TAGAP in mice ameliorated the clinical features of experimental autoimmune encephalomyelitis, indicating that TAGAP is critical for disease progression
Title: T-cell activation RhoGTPase-activating protein plays an important role in T(H)17-cell differentiation.
t-complex responder locus, Tcr, rescues t-sperm but not +-sperm from defective products of t-complex distorter loci, Tcds
Title: Sperm motility-activating complex formed by t-complex distorters.
Experimental and computational approaches yield a high-resolution, 1-Mb physical map of the region harboring the mouse t haplotype sterility factor, tcs1
Title: Experimental and computational approaches yield a high-resolution, 1-Mb physical map of the region harboring the mouse t haplotype sterility factor, tcs1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124372 (e-PCR)
- UniSTS:161194

NoName (e-PCR)
- UniSTS:237565

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: T-cell activation Rho GTPase-activating protein

Names: T-cell activation GTPase-activating protein 1; t-complex distorter 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145968.2 → NP_666080.1 T-cell activation Rho GTPase-activating protein

See identical proteins and their annotated locations for NP_666080.1

Status: VALIDATED

Source sequence(s)

AC164314, BC150728, BY117429

Consensus CDS

CCDS28379.1

UniProtKB/Swiss-Prot

B2RWW0, Q8K2L9, Q920D6

UniProtKB/TrEMBL

A0A2X0SG59

Related

ENSMUSP00000047431.8, ENSMUST00000036370.8

Conserved Domains (1) summary

cd04402
Location:85 → 281

RhoGAP_ARHGAP20; RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

8144832..8153729

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523354.5 → XP_006523417.1 T-cell activation Rho GTPase-activating protein isoform X1

UniProtKB/TrEMBL

A0A2X0SG59

Conserved Domains (1) summary

cd04402
Location:79 → 275

RhoGAP_ARHGAP20; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces ...